Reactome | MMP10 [extracellular region]

MMP10 [extracellular region]

Stable Identifier

R-HSA-1442488

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

Stromelysin-2, MMP10_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P09238 MMP10

Gene Names

MMP10, STMY2

Chain

signal peptide:1-17, propeptide:18-98, chain:99-476

Reference Genes

BioGPS Gene:4319 MMP10

COSMIC (genes):MMP10 MMP10

CTD Gene:4319 MMP10

dbSNP Gene:4319 MMP10

ENSEMBL:ENSG00000166670 MMP10

HGNC:7156 MMP10

KEGG:hsa:4319 MMP10

Monarch:4319 MMP10

NCBI Gene:4319 MMP10

OMIM:185260 MMP10

UCSC:P09238 MMP10

Reference Transcript

RefSeq:NM_002425.2 MMP10

Other Identifiers

1006_at

11727906_at

16743707

205680_PM_at

205680_at

3388789

3388790

3388791

3388793

3388794

3388796

3388797

3388798

3388799

3388800

3388801

3388802

3388803

3388804

3388805

3388806

3388853

4319

7951259

A_23_P13094

GE63357

GO:0003824

GO:0004222

GO:0004252

GO:0005576

GO:0005615

GO:0006508

GO:0008237

GO:0008270

GO:0016787

GO:0022617

GO:0030198

GO:0030312

GO:0030574

GO:0031012

GO:0046872

GO:0140096

HMNXSV003020736

ILMN_1741847

PH_hs_0000305

TC11002233.hg

X07820_at

g4505204_3p_at

Participates

as a member of

as a candidate of

as an output of

Activation of proMMP10 (Homo sapiens)

Other forms of this molecule

MMP10(18-476) [extracellular region]

Inferred To

MMP10 [extracellular region] (Bos taurus)

MMP10 [extracellular region] (Caenorhabditis elegans)

MMP10 [extracellular region] (Canis familiaris)

MMP10 [extracellular region] (Danio rerio)

MMP10 [extracellular region] (Drosophila melanogaster)

MMP10 [extracellular region] (Gallus gallus)

MMP10 [extracellular region] (Mus musculus)

MMP10 [extracellular region] (Rattus norvegicus)

MMP10 [extracellular region] (Sus scrofa)

MMP10 [extracellular region] (Xenopus tropicalis)

Homologues of MMP10 [extracellular region] (Caenorhabditis elegans)

Homologues of MMP10 [extracellular region] (Drosophila melanogaster)

Homologues of MMP10 [extracellular region] (Gallus gallus)

Homologues of MMP10 [extracellular region] (Mus musculus)

Homologues of MMP10 [extracellular region] (Rattus norvegicus)

Homologues of MMP10 [extracellular region] (Xenopus tropicalis)

Cross References

Guide to Pharmacology - Targets

1634

ENSEMBL

ENSG00000166670, ENST00000279441, ENSP00000279441

OpenTargets

ENSG00000166670

ZINC - Substances

MMP10_HUMAN

ZINC target

P09238

PRO

P09238

PDB

3V96, 4ILW, 1Q3A

ZINC - Investigational

MMP10_HUMAN

IntEnz

3.4.24.22

GeneCards

MMP10

HPA

ENSG00000166670-MMP10

Pharos - Targets

P09238

ZINC - Predictions - Purchasable

MMP10_HUMAN

HMDB Protein

HMDBP07801

Interactors (9)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UHG2 PCS1N			0.527	2
UniProt:P01033 TIMP1	4	p-TIMP1 [endoplasmic reticulum lumen] (R-HSA-8957082) TIMP1 [endoplasmic reticulum lumen] (R-HSA-8956691) TIMP1 [extracellular region] (R-HSA-349743) TIMP1 [platelet alpha granule lumen] (R-HSA-349745)	0.527	3
UniProt:P33908 MAN1A1	2	MAN1A1 [transport vesicle] (R-HSA-8847488) MAN1A1 [Golgi membrane] (R-HSA-964767)	0.527	3
UniProt:P08254 MMP3	6	MMP3(100-477) [extracellular region] (R-HSA-1430778) MMP3 [extracellular region] (R-HSA-8943665) MMP3(18-477) [extracellular region] (R-HSA-1604707) MMP3(55-477) [extracellular region] (R-HSA-1604735) MMP3(18-54) [extracellular region] (R-HSA-1604705) MMP3(55-99) [extracellular region] (R-HSA-1604687)	0.527	3
UniProt:Q9NT22 EMILIN3	1	EMILIN3 [extracellular region] (R-HSA-2161272)	0.527	2
UniProt:P02649 APOE	10	APOE [extracellular region] (R-HSA-174646) APOE [endoplasmic reticulum lumen] (R-HSA-6784908) p-APOE [endoplasmic reticulum lumen] (R-HSA-8956980) APOE [endocytic vesicle lumen] (R-HSA-3221641) APOE-4 [extracellular region] (R-HSA-9711070) APOE [plasma membrane] (R-HSA-174615) APOE [clathrin-coated endocytic vesicle membrane] (R-HSA-174651) APOE [endosome membrane] (R-HSA-174766) APOE [endosome lumen] (R-HSA-174804) APOE [early endosome] (R-HSA-2429687)	0.527	2
UniProt:P41273 TNFSF9	1	TNFSF9 [plasma membrane] (R-HSA-5667144)	0.527	2
UniProt:Q14766 LTBP1	3	p-LTBP1 [endoplasmic reticulum lumen] (R-HSA-8957050) LTBP1 [endoplasmic reticulum lumen] (R-HSA-8956770) LTBP1 [extracellular region] (R-HSA-2161391)	0.527	2
UniProt:P22466 GAL	1	GAL [extracellular region] (R-HSA-389038)	0.527	2

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