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p-T178,S539-PPARGC1A [nucleoplasm]
Stable Identifier
R-HSA-1592204
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S539,T178-PPARGC1A, p-T178-S539-PPARGC1A, Peroxisome proliferator-activated receptor gamma coactivator 1-alpha, PRGC1_HUMAN, PPARGC1A
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Heme signaling (Homo sapiens)
Expression of PPARGC1A (PGC-1alpha) (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
Circadian Clock (Homo sapiens)
Expression of PPARGC1A (PGC-1alpha) (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
Organelle biogenesis and maintenance (Homo sapiens)
Mitochondrial biogenesis (Homo sapiens)
Activation of PPARGC1A (PGC-1alpha) by phosphorylation (Homo sapiens)
AMPK phosphorylates PPARGC1A (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
Transcriptional activation of mitochondrial biogenesis (Homo sapiens)
Expression of ESRRA (ERR1, ERRalpha) (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
Expression of GABPA (NRF2 alpha subunit) (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
Expression of NRF1 (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
Expression of PPARGC1A (PGC-1alpha) (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
Expression of SIRT3 (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
Expression of TFAM (Homo sapiens)
TFAM gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
TFAM gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
Expression of TFB1M (Homo sapiens)
TFB1M gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
TFB1M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
Expression of TFB2M (Homo sapiens)
TFB2M gene:NRF1:NRF2:p-PPARGC1A,PPRC1 [nucleoplasm] (Homo sapiens)
TFB2M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFAM promoter (Homo sapiens)
TFAM gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFB1M promoter (Homo sapiens)
TFB1M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
NRF1:p-PPARGC1A, NRF2 bind the TFB2M promoter (Homo sapiens)
TFB2M gene:NRF1:p-PPARGC1A:NRF2 [nucleoplasm] (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
p-PPARGC1A [nucleoplasm] (Homo sapiens)
p-T178,S539-PPARGC1A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q9UBK2 PPARGC1A
Gene Names
PPARGC1A, LEM6, PGC1, PGC1A, PPARGC1
Chain
chain:1-798
Reference Genes
BioGPS Gene:10891 PPARGC1A
COSMIC (genes):PPARGC1A PPARGC1A
CTD Gene:10891 PPARGC1A
dbSNP Gene:10891 PPARGC1A
ENSEMBL:ENSG00000109819 PPARGC1A
HGNC:9237 PPARGC1A
KEGG:hsa:10891 PPARGC1A
Monarch:10891 PPARGC1A
NCBI Gene:10891 PPARGC1A
OMIM:604517 PPARGC1A
UCSC:Q9UBK2 PPARGC1A
Reference Transcript
RefSeq:NM_001330752.1 PPARGC1A
RefSeq:XM_011513771.1 PPARGC1A
RefSeq:NM_001330751.1 PPARGC1A
RefSeq:NM_001330753.1 PPARGC1A
RefSeq:NM_013261.4 PPARGC1A
Other Identifiers
10891
11723403_at
11723404_at
11750243_a_at
11750479_a_at
1569141_PM_a_at
1569141_a_at
16974830
219195_PM_at
219195_at
2763556
2763557
2763558
2763559
2763560
2763561
2763562
2763563
2763564
2763565
2763566
2763567
2763571
2763573
2763576
2763577
2763578
2763579
2763580
2763581
2763586
2763587
2763589
2763590
2763591
2763592
2763593
2763594
2763595
2763604
2763607
2763608
2763609
2763614
2763615
2763616
2763619
2763623
2763624
2763626
2763627
2763628
2763630
2763631
2763632
2763633
2763634
47588_at
70163_at
8099633
81839_at
91360_at
A_23_P18447
A_24_P303052
GE475427
GE62667
GO:0000785
GO:0001659
GO:0001678
GO:0002021
GO:0003676
GO:0003677
GO:0003712
GO:0003713
GO:0003723
GO:0005515
GO:0005634
GO:0005654
GO:0005737
GO:0005829
GO:0005975
GO:0006091
GO:0006094
GO:0006355
GO:0006367
GO:0006397
GO:0006629
GO:0007005
GO:0007586
GO:0008134
GO:0008380
GO:0010628
GO:0012501
GO:0014850
GO:0016071
GO:0016605
GO:0016922
GO:0019395
GO:0022904
GO:0030154
GO:0030374
GO:0031490
GO:0031625
GO:0032922
GO:0034599
GO:0042594
GO:0042752
GO:0043226
GO:0043524
GO:0043565
GO:0045333
GO:0045722
GO:0045893
GO:0045944
GO:0046321
GO:0048511
GO:0048662
GO:0048856
GO:0050821
GO:0050873
GO:0051091
GO:0051402
GO:0060090
GO:0060612
GO:0061629
GO:0065003
GO:0097009
GO:0106222
GO:0120162
GO:0140110
GO:0140297
HMNXSV003019598
Hs2.284627.1.S1_3p_s_at
ILMN_1750062
ILMN_1857687
PH_hs_0011689
g7019498_3p_at
Participates
as an output of
AMPK phosphorylates PPARGC1A (Homo sapiens)
as a member of
p-PPARGC1A [nucleoplasm] (Homo sapiens)
Other forms of this molecule
PPARGC1A [nucleoplasm]
p-T263,S266,T299-PPARGC1A [nucleoplasm]
monoSUMO1-K184-PPARGC1A [nucleoplasm]
Inferred To
phospho-Ppargc1a [nucleoplasm]
(Mus musculus)
phospho-ppargc1a [nucleoplasm]
(Xenopus tropicalis)
phospho-PPARGC1A [nucleoplasm]
(Bos taurus)
phospho-PPARGC1A [nucleoplasm]
(Canis familiaris)
phospho-PPARGC1A [nucleoplasm]
(Sus scrofa)
phospho-p-T178,S539-PPARGC1A [nucleoplasm]
(Gallus gallus)
phospho-srl [nucleoplasm]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-threonine at 178
Coordinate
178
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Name
O-phospho-L-serine at 539
Coordinate
539
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Cross References
RefSeq
NP_037393.1
,
XP_011512073.1
,
NP_001317682.1
,
NP_001317681.1
,
NP_001317680.1
OpenTargets
ENSG00000109819
ENSEMBL
ENSP00000264867
,
ENSP00000423075
,
ENST00000506055
,
ENST00000264867
,
ENSP00000421632
,
ENSP00000481498
,
ENST00000513205
,
ENST00000613098
HPA
ENSG00000109819-PPARGC1A
PRO
Q9UBK2
Pharos - Targets
Q9UBK2
Orphanet
PPARGC1A
GlyGen
Q9UBK2
PDB
8DK4
,
6KXY
,
1XB7
,
5TWO
,
6MS7
,
3V9T
,
7PRX
,
6IZM
,
6W9L
,
7PRV
,
6KXX
,
5Q0I
,
4QK4
,
6K0T
,
6AD9
,
3U9Q
,
6NWL
,
6NWK
,
7KHT
,
4QJR
,
3B1M
,
3V9V
,
6LN4
,
8BF1
,
6IZN
,
6FZP
,
6W9K
,
3D24
,
5Z5S
,
7E2E
,
7PRW
,
6FZF
,
3CS8
,
5UNJ
,
5Z6S
,
6T1V
Interactors (10)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P11474 ESRRA
1
ESRRA [nucleoplasm]
(R-HSA-446159)
0.894
20
UniProt:P62508 ESRRG
1
ESRRG [nucleoplasm]
(R-HSA-446166)
0.722
4
UniProt:P41235 HNF4A
1
HNF4A [nucleoplasm]
(R-HSA-446162)
0.655
4
UniProt:P37231 PPARG
2
monoSUMO1-K107,K395-PPARG [nucleoplasm]
(R-HSA-4717444)
PPARG [nucleoplasm]
(R-HSA-446172)
0.592
2
UniProt:P10826-2 RARB
0.556
3
UniProt:P62508-3 ESRRG
0.556
5
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.553
2
IntAct:EBI-20184588 DR0
0.544
2
UniProt:P42704 LRPPRC
1
LRPPRC [mitochondrial matrix]
(R-HSA-5336174)
0.524
2
UniProt:P37231-2 PPARG
1
PPARG1 [nucleoplasm]
(R-HSA-9841933)
0.462
2
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