Reactome | ATP5D [mitochondrial matrix]

ATP5D [mitochondrial matrix]

Stable Identifier

R-HSA-164574

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

ATP synthase delta chain

Locations in the PathwayBrowser

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Metabolism (Homo sapiens)

- The citric acid (TCA) cycle and respiratory electron transport (Homo sapiens)
  - Respiratory electron transport, ATP synthesis by chemiosmotic coupling, and heat production by uncoupling proteins. (Homo sapiens)
    - Formation of ATP by chemiosmotic coupling (Homo sapiens)
      - ADP and Pi bind to ATPase (Homo sapiens)
        
        ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5D [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5D [mitochondrial matrix] (Homo sapiens)
      - ATPase synthesizes ATP (Homo sapiens)
        
        ATPase:ADP:Pi [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5D [mitochondrial matrix] (Homo sapiens)
        
        ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5D [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5D [mitochondrial matrix] (Homo sapiens)
      - Enzyme-bound ATP is released (Homo sapiens)
        
        ATPase:ATP [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5D [mitochondrial matrix] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5D [mitochondrial matrix] (Homo sapiens)

Organelle biogenesis and maintenance (Homo sapiens)

- Mitochondrial biogenesis (Homo sapiens)
  - Cristae formation (Homo sapiens)
    - F1Fo ATP synthase dimerizes (Homo sapiens)
      - F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5D [mitochondrial matrix] (Homo sapiens)
      - F1Fo ATP synthase dimer [mitochondrial inner membrane] (Homo sapiens)
        
        F1Fo ATP synthase [mitochondrial inner membrane] (Homo sapiens)
        
        ATPase CF(1) [mitochondrial matrix] (Homo sapiens)
        
        ATP5D [mitochondrial matrix] (Homo sapiens)

External Reference Information

External Reference

UniProt:P30049 ATP5F1D

Gene Names

ATP5F1D, ATP5D

Chain

transit peptide:1-22, chain:23-168

Reference Genes

BioGPS Gene:513 ATP5F1D

COSMIC (genes):ATP5F1D ATP5F1D

CTD Gene:513 ATP5F1D

dbSNP Gene:513 ATP5F1D

ENSEMBL:ENSG00000099624.8 ATP5F1D

HGNC:837 ATP5F1D

KEGG Gene (Homo sapiens):513 ATP5F1D

Monarch:513 ATP5F1D

NCBI Gene:513 ATP5F1D

OMIM:603150 ATP5F1D

UCSC:P30049 ATP5F1D

Reference Transcript

Other Identifiers

11720635_a_at

11744222_a_at

11744223_x_at

16856476

203926_PM_x_at

203926_x_at

213041_PM_s_at

213041_s_at

37992_s_at

37993_at

3815612

3815613

3815615

3815617

3815618

3815619

3815620

3815621

45383_at

513

8024219

A_23_P5089

A_24_P168456

GE59890

GO:0000275

GO:0003824

GO:0005215

GO:0005515

GO:0005524

GO:0005739

GO:0005743

GO:0005753

GO:0005759

GO:0006091

GO:0006754

GO:0006811

GO:0007005

GO:0009060

GO:0015986

GO:0016020

GO:0016874

GO:0033615

GO:0042776

GO:0043226

GO:0043531

GO:0045261

GO:0046688

GO:0046933

GO:0055085

GO:0055086

GO:0065003

GO:1901135

GO:1902600

Hs.89761.1.S1_3p_a_at

ILMN_1653599

ILMN_1679178

PH_hs_0025100

PH_hs_0034153

TC19000032.hg

X63422_at

Participates

as a component of

ATPase CF(1) [mitochondrial matrix] (Homo sapiens)

Inferred To

ATP5F1D [mitochondrial matrix] (Bos taurus)

ATP5F1D [mitochondrial matrix] (Sus scrofa)

ATPsyndelta [mitochondrial matrix] (Drosophila melanogaster)

Atp5f1d [mitochondrial matrix] (Mus musculus)

Atp5f1d [mitochondrial matrix] (Rattus norvegicus)

ATP5D [mitochondrial matrix] (Caenorhabditis elegans)

ATP5D [mitochondrial matrix] (Canis familiaris)

ATP5D [mitochondrial matrix] (Danio rerio)

ATP5D [mitochondrial matrix] (Gallus gallus)

Cross References

RefSeq

NP_001678.1, NP_001001975.1

Guide to Pharmacology - Targets

799

OpenTargets

ENSG00000099624

HPA

ENSG00000099624-ATP5F1D

GeneCards

P30049

Ensembl

ENSP00000215375, ENST00000591660, ENSP00000464863, ENSP00000378995, ENSG00000099624, ENST00000215375, ENST00000395633

PRO

P30049

Pharos - Targets

P30049

HMDB Protein

HMDBP01215

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05919 vpu	6	VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2