Reactome | ATP5B(1-529) [mitochondrial inner membrane]

ATP5B(1-529) [mitochondrial inner membrane]

Stable Identifier

R-HSA-1299440

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

ATP5B precursor, ATP synthase beta chain precursor, ATP synthase subunit beta, mitochondrial

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P06576 ATP5F1B

Gene Names

ATP5F1B, ATP5B, ATPMB, ATPSB

Chain

transit peptide:1-47, chain:48-529

Reference Genes

BioGPS Gene:506 ATP5F1B

COSMIC (genes):ATP5F1B ATP5F1B

CTD Gene:506 ATP5F1B

dbSNP Gene:506 ATP5F1B

ENSEMBL:ENSG00000110955 ATP5B

HGNC:830 ATP5F1B

KEGG:hsa:506 ATP5F1B

Monarch:506 ATP5F1B

NCBI Gene:506 ATP5F1B

OMIM:102910 ATP5F1B

UCSC:P06576 ATP5F1B

Reference Transcript

RefSeq:NM_001686.3 ATP5F1B

Other Identifiers

11724190_s_at

11757873_x_at

16766260

16766279

201322_PM_at

201322_at

3458032

3458034

3458035

3458036

3458037

3458038

3458039

3458040

3458041

3458042

3458043

3458044

3458045

3458046

3458047

3458048

3458050

3458051

3458054

3458055

3458056

506

7964234

7964246

A_21_P0000374

A_23_P33216

GE57035

GO:0001525

GO:0001649

GO:0003824

GO:0005215

GO:0005515

GO:0005524

GO:0005634

GO:0005737

GO:0005739

GO:0005743

GO:0005759

GO:0005886

GO:0006091

GO:0006629

GO:0006754

GO:0006811

GO:0006933

GO:0009986

GO:0015986

GO:0016020

GO:0016469

GO:0016787

GO:0016874

GO:0016887

GO:0030154

GO:0031090

GO:0031966

GO:0042288

GO:0042645

GO:0042776

GO:0043226

GO:0043532

GO:0043536

GO:0045259

GO:0045261

GO:0045267

GO:0046034

GO:0046933

GO:0046961

GO:0051453

GO:0055085

GO:0055086

GO:0070062

GO:0098761

GO:0140657

GO:1901135

GO:1902600

HMNXSV003021703

HMNXSV003039648

ILMN_1772132

M19483_at

PH_hs_0019285

RNA33693|snoRNA_scaRNA_289_75

TC12001609.hg

TC12001610.hg

g4502294_3p_at

Participates

as a candidate of

Precursor Cargo of TIMM23 SORT [mitochondrial inner membrane] (Homo sapiens)

Other forms of this molecule

ATP5F1B [mitochondrial matrix]

ATP5B(1-529) [cytosol]

ATP5B(1-529) [mitochondrial intermembrane space]

ATP5B(1-47) [mitochondrial matrix]

ATP5B [mitochondrial inner membrane]

Cross References

Guide to Pharmacology - Targets

797

OpenTargets

ENSG00000110955

ENSEMBL

ENSP00000262030, ENST00000262030

HPA

ENSG00000110955-ATP5F1B

PRO

P06576

Pharos - Targets

P06576

GlyGen

P06576

HMDB Protein

HMDBP01465

PDB

8H9E, 8H9T, 8H9S, 8H9L, 8H9I, 8KI3, 8H9V, 8H9U, 8H9P

Interactors (44)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8N5M1 ATPF2			0.801	8
UniProt:P25705 ATP5F1A	3	ATP5F1A [mitochondrial matrix] (R-HSA-164575) ATP5A1(1-553) [cytosol] (R-HSA-1267955) ATP5A1(1-553) [mitochondrial intermembrane space] (R-HSA-1267978)	0.744	7
UniProt:P24539 ATP5PB	1	ATP5PB [mitochondrial inner membrane] (R-HSA-164537)	0.669	5
UniProt:Q9UII2 ATIF1			0.669	4
UniProt:Q5TC12 ATPF1			0.659	3
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.643	4
UniProt:P25106 ACKR3	1	CXCR7 [plasma membrane] (R-HSA-373859)	0.643	3
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	20
UniProt:Q5T1Q4 S35F1			0.589	2
UniProt:P63104 YWHAZ	2	YWHAZ [cytosol] (R-HSA-206099) YWHAZ [nucleoplasm] (R-HSA-450469)	0.564	2
UniProt:O75947 ATP5PD	1	ATP5PD [mitochondrial inner membrane] (R-HSA-50522)	0.564	2
UniProt:P28566 HTR1E	1	HTR1E [plasma membrane] (R-HSA-390960)	0.564	2
UniProt:Q13895 BYSL	2	BYSL [nucleoplasm] (R-HSA-6791526) BYSL [cytosol] (R-HSA-6791518)	0.556	3
UniProt:P54253 ATX1			0.556	3
UniProt:Q8N448 LNX2			0.553	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.536	2
UniProt:Q99679 GPR21			0.527	2
UniProt:P41587 VIPR2	1	VIPR2 [plasma membrane] (R-HSA-420227)	0.527	3
UniProt:P51451 BLK	2	MyrG2-BLK [plasma membrane] (R-HSA-9606871) BLK [cytosol] (R-HSA-983580)	0.527	2
UniProt:Q9HC97 GPR35	1	GPR35 [plasma membrane] (R-HSA-3295332)	0.527	2
UniProt:Q9H244 P2RY12	1	P2RY12 [plasma membrane] (R-HSA-391959)	0.527	2
UniProt:P25090 FPR2	4	FPR2 [plasma membrane] (R-HSA-416408) FPR2 [ficolin-1-rich granule membrane] (R-HSA-6803335) FPR2 [specific granule membrane] (R-HSA-6803319) FPR2 [tertiary granule membrane] (R-HSA-6803296)	0.527	2
UniProt:Q5K4L6 SLC27A3	1	SLC27A3 [mitochondrial matrix] (R-HSA-5216184)	0.527	2
UniProt:Q86VR2 RETR3			0.527	2
UniProt:P28335 HTR2C	1	HTR2C [plasma membrane] (R-HSA-390965)	0.527	2
UniProt:Q8IUW5 RELL1			0.527	2
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.527	3
UniProt:P48201 ATP5MC3	1	ATP5MC3 [mitochondrial inner membrane] (R-HSA-5216110)	0.527	2
UniProt:P48047 ATP5PO	1	ATP5PO [mitochondrial inner membrane] (R-HSA-164533)	0.527	2
UniProt:Q5I7T1 ALG10B	1	ALG10B [endoplasmic reticulum membrane] (R-HSA-449653)	0.527	2
UniProt:O95136 S1PR2	1	S1PR2 [plasma membrane] (R-HSA-419419)	0.527	2
UniProt:P30049 ATP5F1D	1	ATP5F1D [mitochondrial matrix] (R-HSA-164574)	0.527	2
UniProt:O75964 ATP5MG	1	ATP5MG [mitochondrial inner membrane] (R-HSA-50518)	0.527	2
UniProt:P32241 VIPR1	1	VIPR1 [plasma membrane] (R-HSA-420157)	0.527	2
UniProt:Q9NX36 DJC28			0.527	2
UniProt:P18859 ATP5PF	1	ATP5PF [mitochondrial inner membrane] (R-HSA-164532)	0.527	3
UniProt:P0DTD1-PRO_0000449624 REP			0.527	2
UniProt:Q7Z7J7 LHPL4			0.527	2
UniProt:Q96G23 CERS2	1	CERS2 [endoplasmic reticulum membrane] (R-HSA-428171)	0.527	2
UniProt:O60512 B4GALT3	1	B4GALT3 [Golgi membrane] (R-HSA-975922)	0.527	4
UniProt:O60779 SLC19A2	1	SLC19A2 [plasma membrane] (R-HSA-199636)	0.527	2
UniProt:P36542 ATP5F1C	1	ATP5F1C [mitochondrial matrix] (R-HSA-164577)	0.499	2
UniProt:A0A0F6B1Q8 A0A0F6B1Q8			0.462	2
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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