Reactome | AP1M1 [cytosol]

AP1M1 [cytosol]

Stable Identifier

R-HSA-167700

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AP-1 mu 1

Locations in the PathwayBrowser

Expand all

Disease (Homo sapiens)

- Infectious disease (Homo sapiens)
  - Viral Infection Pathways (Homo sapiens)
    - HIV Infection (Homo sapiens)
      - Host Interactions of HIV factors (Homo sapiens)
        
        The role of Nef in HIV-1 replication and disease pathogenesis (Homo sapiens)
        
        Nef-mediates down modulation of cell surface receptors by recruiting them to clathrin adapters (Homo sapiens)
        
        Nef mediated downregulation of MHC class I complex cell surface expression (Homo sapiens)
        
        Degradation of MHC I Complex (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M1 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M1 [cytosol] (Homo sapiens)
        
        Formation of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M1 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M1 [cytosol] (Homo sapiens)
        
        Transport of MHC I:Nef:AP-1:PACS-1 Complex (Homo sapiens)
        
        Nef:class I MHC complex:AP-1:PACS-1 Complex [early endosome membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M1 [cytosol] (Homo sapiens)
        
        Nef:class I MHC complex:Ap-1:PACS-1 Complex [Golgi membrane] (Homo sapiens)
        
        AP-1 Complex [cytosol] (Homo sapiens)
        
        AP-1 mu [cytosol] (Homo sapiens)
        
        AP1M1 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9BXS5 AP1M1

Gene Names

AP1M1, CLTNM

Chain

initiator methionine:1, chain:2-423

Reference Genes

BioGPS Gene:8907 AP1M1

COSMIC (genes):AP1M1 AP1M1

CTD Gene:8907 AP1M1

dbSNP Gene:8907 AP1M1

ENSEMBL:ENSG00000072958 AP1M1

ENSEMBL:ENSG00000072958.9 AP1M1

HGNC:13667 AP1M1

KEGG Gene (Homo sapiens):8907 AP1M1

Monarch:8907 AP1M1

NCBI Gene:8907 AP1M1

OMIM:603535 AP1M1

UCSC:Q9BXS5 AP1M1

Reference Transcript

Other Identifiers

11715762_s_at

11747500_a_at

16859300

223024_PM_at

223024_at

223025_PM_s_at

223025_s_at

2610786

3251363

3571426

3823626

3823627

3823628

3823632

3823636

3823639

3823641

3823648

3823649

3823650

3823651

3823654

3823657

3823659

3823660

3823661

3823662

3823663

3823664

3823665

45767_at

8026548

8907

A_14_P106114

A_23_P55802

GE86671

GO:0000139

GO:0005515

GO:0005576

GO:0005615

GO:0005737

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005773

GO:0005794

GO:0005829

GO:0005886

GO:0006886

GO:0015031

GO:0016020

GO:0016192

GO:0030121

GO:0030131

GO:0030136

GO:0030154

GO:0030659

GO:0030665

GO:0031410

GO:0032438

GO:0032588

GO:0035579

GO:0035615

GO:0035646

GO:0043226

GO:0043231

GO:0060090

GO:0060155

GO:0070062

GO:1903232

HMNXSV003004687

ILMN_1754738

PH_hs_0004130

TC19000320.hg

g13491973_3p_a_at

Participates

as a member of

AP-1 mu [cytosol] (Homo sapiens)

Other forms of this molecule

AP1M1 [cytoplasmic vesicle membrane]

AP1M1 [Golgi membrane]

AP1M1 [lysosomal membrane]

AP1M1 [trans-Golgi network membrane]

AP1M1 [plasma membrane]

AP1M1 [specific granule membrane]

Inferred To

AP-1mu [cytosol] (Drosophila melanogaster)

unc-101 [cytosol] (Caenorhabditis elegans)

AP1M1 [cytosol] (Bos taurus)

AP1M1 [cytosol] (Canis familiaris)

AP1M1 [cytosol] (Danio rerio)

AP1M1 [cytosol] (Gallus gallus)

AP1M1 [cytosol] (Plasmodium falciparum)

AP1M1 [cytosol] (Sus scrofa)

Ap1m1 [cytosol] (Mus musculus)

Ap1m1 [cytosol] (Rattus norvegicus)

ap1m1 [cytosol] (Xenopus tropicalis)

apm1 [cytosol] (Dictyostelium discoideum)

apm1 [cytosol] (Schizosaccharomyces pombe)

APM1 [cytosol] (Saccharomyces cerevisiae)

Cross References

RefSeq

NP_115882.1, NP_001123996.1

OpenTargets

ENSG00000072958

GeneCards

Q9BXS5

HPA

ENSG00000072958-AP1M1

Ensembl

ENSP00000388996, ENSP00000291439, ENST00000444449, ENSG00000072958, ENST00000291439

PRO

Q9BXS5

Pharos - Targets

Q9BXS5

Interactors (11)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9HBZ2 ARNT2	1	ARNT2 [nucleoplasm] (R-HSA-8936838)	0.556	3
UniProt:P26367 PAX6	1	PAX6 [nucleoplasm] (R-HSA-3009044)	0.556	3
UniProt:P14373 TRIM27	2	TRIM27 [nucleoplasm] (R-HSA-2997690) TRIM27 [cytosol] (R-HSA-8851002)	0.556	3
UniProt:P21741 MDK	1	MDK [extracellular region] (R-HSA-2160953)	0.556	3
UniProt:Q8N5F7 NKAP	1	NKAP [nucleoplasm] (R-HSA-9769602)	0.556	3
UniProt:Q9Y2T1 AXIN2	4	AXIN2 [cytosol] (R-HSA-3640821) RibC-AXIN2 [cytosol] (R-HSA-3640842) Ub-RibC-AXIN2 [cytosol] (R-HSA-3640859) ub-AXIN2 [cytosol] (R-HSA-4641131)	0.556	3
UniProt:Q9UGI0 ZRANB1	1	ZRANB1 [cytosol] (R-HSA-6781939)	0.556	3
UniProt:P18848 ATF4	2	ATF4 [cytosol] (R-HSA-381084) ATF4 [nucleoplasm] (R-HSA-381016)	0.556	3
UniProt:Q9NRD5 PICK1	2	PICK1 [plasma membrane] (R-HSA-416989) PICK1 [endocytic vesicle membrane] (R-HSA-417017)	0.556	3
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.556	3
UniProt:P04578 env	7	Surface protein gp120 (P04578) [cytosol] (R-HIV-189269) Transmembrane protein gp41 (P04578) [cytosol] (R-HIV-189359) Glycosylated Envelope glycoprotein gp160 [Golgi membrane] (R-HIV-3149443) Envelope glycoprotein gp160 [endoplasmic reticulum membrane] (R-HIV-189343) Transmembrane protein gp41 [viral envelope] (R-HIV-171195) ENV [viral envelope] (R-HIV-173439) Surface protein gp120 [viral envelope] (R-HIV-171211)	0.462	2