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Frs2-mediated activation
Stable Identifier
R-HSA-170968
Type
Pathway
Species
Homo sapiens
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by NTRKs (Homo sapiens)
Signaling by NTRK1 (TRKA) (Homo sapiens)
Signalling to ERKs (Homo sapiens)
Prolonged ERK activation events (Homo sapiens)
Frs2-mediated activation (Homo sapiens)
General
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The adaptor protein Frs2 (Fibroblast growth factor receptor substrate 2) can mediate the prolonged activation of the MAPK (ERK) cascade.
Literature References
PubMed ID
Title
Journal
Year
9069267
Signal transduction by the neurotrophin receptors
Miller, FD
,
Kaplan, DR
Curr Opin Cell Biol
1997
Participants
Events
FRS2 binds to active TrkA receptor
(Homo sapiens)
FRS2 is phosphorylated by active TrkA receptor
(Homo sapiens)
p-FRS2 binds CRKL
(Homo sapiens)
p-FRS2:CRKL binds C3G
(Homo sapiens)
(Frs2)C3G stimulates nucleotide exchange on Rap1
(Homo sapiens)
(Frs2)Rap1-GTP binds to and activates B-Raf
(Homo sapiens)
BRAF autophosphorylates downstream of RAP1 and NGF
(Homo sapiens)
Activated BRAF recruits MAP2Ks and MAPKs to the endosome
(Homo sapiens)
Activated BRAF phosphorylates MAP2K dimers downstream of RAP1 and NGF
(Homo sapiens)
MAP2Ks phosphorylate MAPKs downstream of BRAF and NGF
(Homo sapiens)
Dissociation of phosphorylated MAP2Ks and MAPKs
(Homo sapiens)
p-T,Y MAPKs dimerize
(Homo sapiens)
p-T,Y MAPK dimers translocate to nucleus
(Homo sapiens)
Participates
as an event of
Prolonged ERK activation events (Homo sapiens)
Event Information
Go Biological Process
MAPK cascade (0000165)
Orthologous Events
Frs2-mediated activation (Bos taurus)
Frs2-mediated activation (Caenorhabditis elegans)
Frs2-mediated activation (Canis familiaris)
Frs2-mediated activation (Danio rerio)
Frs2-mediated activation (Dictyostelium discoideum)
Frs2-mediated activation (Drosophila melanogaster)
Frs2-mediated activation (Gallus gallus)
Frs2-mediated activation (Mus musculus)
Frs2-mediated activation (Plasmodium falciparum)
Frs2-mediated activation (Rattus norvegicus)
Frs2-mediated activation (Saccharomyces cerevisiae)
Frs2-mediated activation (Schizosaccharomyces pombe)
Frs2-mediated activation (Sus scrofa)
Frs2-mediated activation (Xenopus tropicalis)
Cross References
BioModels Database
BIOMD0000000653
,
BIOMD0000000654
,
BIOMD0000000655
,
BIOMD0000000648
,
BIOMD0000000652
,
BIOMD0000000883
,
BIOMD0000000664
,
BIOMD0000000656
Authored
Nasi, S (2006-10-10)
Annibali, D (2006-10-10)
Reviewed
Greene, LA (2007-11-08)
Created
Jassal, B (2006-01-25)
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