Reactome | C5 beta chain [extracellular region]

C5 beta chain [extracellular region]

Stable Identifier

R-HSA-173675

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

extracellular region

Synonyms

C5(19-673)

Icon

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P01031 C5

Gene Names

C5, CPAMD4

Chain

signal peptide:1-18, chain:19-673, propeptide:674-677, chain:678-1676, chain:678-751, chain:752-1676

Reference Genes

BioGPS Gene:727 C5

COSMIC (genes):C5 C5

CTD Gene:727 C5

dbSNP Gene:727 C5

ENSEMBL:ENSG00000106804 C5

HGNC:1331 C5

KEGG:hsa:727 C5

Monarch:727 C5

NCBI Gene:727 C5

OMIM:120900 C5

UCSC:P01031 C5

Reference Transcript

Other Identifiers

11737948_a_at

17097955

205500_PM_at

205500_at

3158514

3223766

3223767

3223768

3223769

3223770

3223771

3223775

3223777

3223778

3223779

3223780

3223781

3223782

3223783

3223784

3223785

3223787

3223788

3223789

3223790

3223792

3223796

3223797

3223798

3223799

3223801

3223803

3223804

3223805

3223807

3223809

3223810

3223811

3223813

3223816

3223817

3223818

3223819

3223820

3223821

3223822

3223824

3223825

3223826

3223827

3223828

3223829

3223830

3223831

3223832

3223833

3223834

3223835

3223836

3223837

3223839

3223841

3223843

3223844

3223845

3223847

3223849

3223850

3223852

3223853

3223857

3223858

3223859

3223860

3223861

37816_at

51716_r_at

727

8163839

A_23_P71855

GE57984

GO:0002376

GO:0004866

GO:0005102

GO:0005515

GO:0005576

GO:0005579

GO:0005615

GO:0006935

GO:0006954

GO:0006956

GO:0006957

GO:0006958

GO:0007166

GO:0007186

GO:0008009

GO:0010575

GO:0010760

GO:0031640

GO:0032722

GO:0043226

GO:0045087

GO:0048018

GO:0048870

GO:0060326

GO:0070062

GO:0098542

GO:0098772

HMNXSV003010080

ILMN_1746819

M65134_s_at

PH_hs_0028696

TC09001542.hg

g4502506_3p_at

Participates

as a component of

Other forms of this molecule

C5a [extracellular region]

C5 alpha chain [extracellular region]

C5b alpha' [extracellular region]

C5a-desArg [extracellular region]

C5aT [extracellular region]

C5(965-1676) [extracellular region]

Inferred To

C5 [extracellular region] (Bos taurus)

C5 [extracellular region] (Canis familiaris)

C5 [extracellular region] (Mus musculus)

C5 [extracellular region] (Rattus norvegicus)

C5 [extracellular region] (Sus scrofa)

Ghost homologue of C5 beta chain [extracellular region] (Xenopus tropicalis)

C5 beta chain [extracellular region] (Gallus gallus)

Cross References

RefSeq

NP_001304092.1, NP_001726.2

OpenTargets

ENSG00000106804

ENSEMBL

ENSG00000106804, ENSP00000223642, ENST00000223642

HPA

ENSG00000106804-C5

GeneCards

PRO

P01031

Pharos - Targets

P01031

Orphanet

PDB

6RQJ, 7NYD, 7Y64, 4E0S, 3PVM, 1CFA, 7NYC, 3CU7, 4UU9, 3KM9, 3KLS, 5B4P, 1KJS, 4P39, 7AD7, 5HCD, 7AD6, 6H04, 5HCE, 5B71, 4A5W, 3HQB, 5HCC, 1XWE, 3HQA, 8JZZ, 8HK5, 6H03, 3PRX, 8B0F, 8IA2, 8B0G, 8HQC, 5I5K, 8B0H, 6RPT

Interactors (22)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q03591 CFHR1	1	CFHR1 [extracellular region] (R-HSA-8851432)	0.611	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:Q8N743 KI3L3			0.556	3
UniProt:Q8WWF3 SSMM1			0.556	3
UniProt:Q13520 AQP6	1	AQP6 [transport vesicle membrane] (R-HSA-431741)	0.556	3
UniProt:O14524-2 NEMP1			0.556	3
UniProt:P78424 PO6F2			0.556	3
UniProt:P23276 KEL	1	KEL [plasma membrane] (R-HSA-5694121)	0.556	3
UniProt:Q7Z7G2 CPLX4			0.556	3
IntAct:EBI-23194662 CCSB ORF ID			0.556	3
UniProt:O15173 PGRMC2	4	PGRMC2 [nuclear envelope] (R-HSA-9707674) PGRMC2 [nucleoplasm] (R-HSA-9707859) PGRMC2 [endoplasmic reticulum membrane] (R-HSA-9714349) PGRMC2 [endosome membrane] (R-HSA-9715090)	0.556	3
UniProt:Q96BA8 CREB3L1	7	CREB3L1 [Golgi membrane] (R-HSA-8874155) CREB3L1(427-519) [Golgi membrane] (R-HSA-8874139) CREB3L1(1-426) [Golgi membrane] (R-HSA-8874153) CREB3L1 [endoplasmic reticulum membrane] (R-HSA-8874157) CREB3L1(1-375) [cytosol] (R-HSA-8874215) CREB3L1(376-426) [Golgi membrane] (R-HSA-8874213) CREB3L1(1-375) [nucleoplasm] (R-HSA-8874222)	0.556	3
UniProt:Q8N4V1 MMGT1	1	MMGT1 [Golgi membrane] (R-HSA-5216137)	0.556	3
UniProt:Q68DC2 ANKS6			0.556	3
UniProt:P13671 C6	1	C6 [extracellular region] (R-HSA-173706)	0.553	2
UniProt:P02748 C9	1	C9(22-559) [extracellular region] (R-HSA-173717)	0.553	2
UniProt:P07358 C8B	1	C8B [extracellular region] (R-HSA-173714)	0.553	2
UniProt:P07357 C8A	1	C8A [extracellular region] (R-HSA-173716)	0.553	2
UniProt:P10643 C7	1	C7 [extracellular region] (R-HSA-173707)	0.553	2
UniProt:P07360 C8G	1	C8G [extracellular region] (R-HSA-173712)	0.553	2
UniProt:Q91132 VCO3			0.544	2
UniProt:D3JIB2 D3JIB2			0.524	3