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C5 beta chain [extracellular region]
Stable Identifier
R-HSA-173675
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
extracellular region
Synonyms
C5(19-673)
Icon
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Complement cascade (Homo sapiens)
Activation of C3 and C5 (Homo sapiens)
Activation of C5 (Homo sapiens)
C5 [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
C5 binds C5 inhibitors (Homo sapiens)
C5 [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
C5:C5 inhibitors [extracellular region] (Homo sapiens)
C5 [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
Regulation of Complement cascade (Homo sapiens)
CD59 inhibits MAC formation (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
CD59:C5b-C9 [plasma membrane] (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
Clusterin binds C5b-C7, C8, C9 (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
Formation of soluble VTN:C5b-C9 (Homo sapiens)
VTN:C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
VTN:C5b:C6:C7:C8:C9 [extracellular region] (Homo sapiens)
VTN:C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
Thrombin, ELANE cleave C5 (Homo sapiens)
C5 [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
C5bT [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
Vitronectin (VTN) binds to C5b:C6:C7 (Homo sapiens)
C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
VTN:C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
Terminal pathway of complement (Homo sapiens)
C5b binds C6 (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
C5b:C6 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
C5b:C6:C7 translocates to the plasma membrane (Homo sapiens)
C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
C5b:C6:C7 [plasma membrane] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
C7 binds C5b:C6 (Homo sapiens)
C5b:C6 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
C8 binds C5b:C6:C7 (Homo sapiens)
C5b:C6:C7 [plasma membrane] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
C9 binds C5b:C6:C7:C8 (Homo sapiens)
C5b:C6:C7:C8 [plasma membrane] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
CLU:C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7, C8, C9 [extracellular region] (Homo sapiens)
C5b:C6:C7 [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
Membrane Attack Complex [plasma membrane] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 beta chain [extracellular region] (Homo sapiens)
External Reference Information
External Reference
UniProt:P01031 C5
Gene Names
C5, CPAMD4
Chain
signal peptide:1-18, chain:19-673, propeptide:674-677, chain:678-1676, chain:678-751, chain:752-1676
Reference Genes
BioGPS Gene:727 C5
COSMIC (genes):C5 C5
CTD Gene:727 C5
dbSNP Gene:727 C5
ENSEMBL:ENSG00000106804.10 C5
HGNC:1331 C5
KEGG Gene (Homo sapiens):727 C5
Monarch:727 C5
NCBI Gene:727 C5
OMIM:120900 C5
UCSC:P01031 C5
Reference Transcript
RefSeq:NM_001735.2 C5
RefSeq:NM_001317163.1 C5
Other Identifiers
11737948_a_at
17097955
205500_PM_at
205500_at
3223775
3223777
3223778
3223780
3223784
3223785
3223787
3223788
3223789
3223790
3223792
3223796
3223797
3223798
3223799
3223803
3223804
3223805
3223807
3223809
3223810
3223811
3223813
3223816
3223817
3223818
3223820
3223821
3223822
3223824
3223825
3223826
3223827
3223828
3223829
3223830
3223831
3223832
3223833
3223835
3223836
3223837
3223839
3223841
3223843
3223844
3223845
3223847
3223849
3223850
37816_at
727
8163839
A_23_P71855
GE57984
GO:0001701
GO:0002376
GO:0004866
GO:0005102
GO:0005515
GO:0005576
GO:0005579
GO:0005615
GO:0005886
GO:0006935
GO:0006954
GO:0006955
GO:0006956
GO:0006957
GO:0006958
GO:0007166
GO:0007186
GO:0008009
GO:0010575
GO:0010760
GO:0019835
GO:0023052
GO:0032722
GO:0043226
GO:0045087
GO:0045766
GO:0048018
GO:0048584
GO:0048856
GO:0048870
GO:0060326
GO:0070062
GO:0098542
GO:0098772
HMNXSV003010080
ILMN_1746819
M65134_s_at
PH_hs_0028696
TC09001542.hg
g4502506_3p_at
Participates
as a component of
C5bT [extracellular region] (Homo sapiens)
C5b [extracellular region] (Homo sapiens)
C5 [extracellular region] (Homo sapiens)
Other forms of this molecule
C5(965-1676) [extracellular region]
C5aT [extracellular region]
C5a-desArg [extracellular region]
C5b alpha' [extracellular region]
C5 alpha chain [extracellular region]
C5a [extracellular region]
Inferred To
c5 [extracellular region]
(Danio rerio)
Tep4 [extracellular region]
(Drosophila melanogaster)
Homologues of C5 beta chain [extracellular region]
(Caenorhabditis elegans)
Homologues of C5 beta chain [extracellular region]
(Drosophila melanogaster)
Mcr [extracellular region]
(Drosophila melanogaster)
Tep2 [extracellular region]
(Drosophila melanogaster)
Tep1 [extracellular region]
(Drosophila melanogaster)
C5 [extracellular region]
(Bos taurus)
C5 [extracellular region]
(Mus musculus)
C5 [extracellular region]
(Sus scrofa)
Ghost homologue of C5 beta chain [extracellular region]
(Rattus norvegicus)
Ghost homologue of C5 beta chain [extracellular region]
(Xenopus tropicalis)
Tep3 [extracellular region]
(Drosophila melanogaster)
tep-1 [extracellular region]
(Caenorhabditis elegans)
C5 beta chain [extracellular region]
(Caenorhabditis elegans)
C5 beta chain [extracellular region]
(Canis familiaris)
C5 beta chain [extracellular region]
(Gallus gallus)
Cross References
RefSeq
NP_001304092.1
,
NP_001726.2
OpenTargets
ENSG00000106804
HPA
ENSG00000106804-C5
GeneCards
P01031
Ensembl
ENSP00000223642
,
ENST00000223642
,
ENSG00000106804
PRO
P01031
Pharos - Targets
P01031
Orphanet
17449
PDB
3HQB
,
1XWE
,
6RPT
,
7NYD
,
5B71
,
7NYC
,
3KLS
,
3PVM
,
3KM9
,
1CFA
,
6H04
,
5I5K
,
5B4P
,
3HQA
,
3CU7
,
5HCE
,
4P39
,
4A5W
,
6H03
,
1KJS
,
5HCC
,
4E0S
,
7AD7
,
7AD6
,
3PRX
,
4UU9
,
6RQJ
,
5HCD
Interactors (22)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q03591 CFHR1
1
CFHR1 [extracellular region]
(R-HSA-8851432)
0.611
3
UniProt:Q68DC2 ANKS6
0.556
3
UniProt:O15173 PGRMC2
2
PGRMC2 [endosome membrane]
(R-HSA-9715090)
PGRMC2 [endoplasmic reticulum membrane]
(R-HSA-9714349)
0.556
3
IntAct:EBI-23194662 CCSB ORF ID
0.556
3
UniProt:Q7Z7G2 CPLX4
0.556
3
UniProt:P23276 KEL
1
KEL [plasma membrane]
(R-HSA-5694121)
0.556
3
UniProt:P78424 PO6F2
0.556
3
UniProt:O14524-2 NEMP1
0.556
3
UniProt:Q15125 EBP
1
EBP [endoplasmic reticulum membrane]
(R-HSA-195697)
0.556
3
UniProt:Q13520 AQP6
1
AQP6 [transport vesicle membrane]
(R-HSA-431741)
0.556
3
UniProt:Q8WWF3 SSMM1
0.556
3
UniProt:Q8N743 KI3L3
0.556
3
UniProt:Q96BA8 CREB3L1
7
CREB3L1 [Golgi membrane]
(R-HSA-8874155)
CREB3L1(427-519) [Golgi membrane]
(R-HSA-8874139)
CREB3L1(1-426) [Golgi membrane]
(R-HSA-8874153)
CREB3L1 [endoplasmic reticulum membrane]
(R-HSA-8874157)
CREB3L1(1-375) [cytosol]
(R-HSA-8874215)
CREB3L1(376-426) [Golgi membrane]
(R-HSA-8874213)
CREB3L1(1-375) [nucleoplasm]
(R-HSA-8874222)
0.556
3
UniProt:Q8N4V1 MMGT1
1
MMGT1 [Golgi membrane]
(R-HSA-5216137)
0.556
3
UniProt:P07360 C8G
1
C8G [extracellular region]
(R-HSA-173712)
0.553
2
UniProt:P10643 C7
1
C7 [extracellular region]
(R-HSA-173707)
0.553
2
UniProt:P07357 C8A
1
C8A [extracellular region]
(R-HSA-173716)
0.553
2
UniProt:P07358 C8B
1
C8B [extracellular region]
(R-HSA-173714)
0.553
2
UniProt:P02748 C9
1
C9(22-559) [extracellular region]
(R-HSA-173717)
0.553
2
UniProt:P13671 C6
1
C6 [extracellular region]
(R-HSA-173706)
0.553
2
UniProt:Q91132 VCO3
0.544
2
UniProt:D3JIB2 D3JIB2
0.524
3
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