Reactome | AQP6 [transport vesicle membrane]

AQP6 [transport vesicle membrane]

Stable Identifier

R-HSA-431741

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

transport vesicle membrane

Synonyms

Aquaporin-6, AQP6_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q13520 AQP6

Gene Names

AQP6, AQP2L

Chain

chain:1-282

Reference Genes

BioGPS Gene:363 AQP6

COSMIC (genes):AQP6 AQP6

CTD Gene:363 AQP6

dbSNP Gene:363 AQP6

ENSEMBL:ENSG00000086159 AQP6

ENSEMBL_homo_sapiens_GENE:ENSG00000086159.14 AQP6

HGNC:639 AQP6

KEGG Gene (Homo sapiens):363 AQP6

Monarch:363 AQP6

NCBI Gene:363 AQP6

OMIM:601383 AQP6

UCSC:Q13520 AQP6

Reference Transcript

RefSeq:NM_001652.3 AQP6

Other Identifiers

11737732_a_at

11755488_a_at

16750982

208435_PM_s_at

208435_s_at

216219_PM_at

216219_at

32423_at

3414333

3414334

3414335

3414336

3414337

3414338

3414341

3414342

3414343

3414345

3414346

3414347

363

7955305

A_14_P115654

A_23_P502060

A_33_P3422247

GE80641

GO:0003014

GO:0003097

GO:0005215

GO:0005515

GO:0005886

GO:0006833

GO:0015112

GO:0015250

GO:0015267

GO:0015670

GO:0015706

GO:0016020

GO:0016324

GO:0030659

GO:0031410

GO:0042476

GO:0043226

GO:0048856

GO:0055085

HMNXSV003009503

Hs.54505.1.S1_3p_at

ILMN_1786381

PH_hs_0003572

g4502184_3p_a_at

Participates

as a component of

AQP6 tetramer [transport vesicle membrane] (Homo sapiens)

Cross References

RefSeq

NP_001643.2

Guide to Pharmacology - Targets

693

OpenTargets

ENSG00000086159

GeneCards

Q13520

HPA

ENSG00000086159-AQP6

Ensembl

ENSG00000086159, ENSP00000320247, ENST00000315520

PRO

Q13520

Pharos - Targets

Q13520

Interactors (57)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q6NT55 CYP4F22	5	CYP4F22 R243H [endoplasmic reticulum membrane] (R-HSA-5602296) CYP4F22 H435Y [endoplasmic reticulum membrane] (R-HSA-5602287) CYP4F22 W521* [endoplasmic reticulum membrane] (R-HSA-5602291) CYP4F22 H436D [endoplasmic reticulum membrane] (R-HSA-5602276) CYP4F22 [endoplasmic reticulum membrane] (R-HSA-211056)	0.556	3
UniProt:O43752 STX6	2	STX6 [trans-Golgi network membrane] (R-HSA-6811007) STX6 [Golgi membrane] (R-HSA-6811004)	0.556	3
UniProt:O95070 YIF1A	1	YIF1A [endoplasmic reticulum membrane] (R-HSA-535599)	0.556	3
UniProt:P37268 FDFT1	1	FDFT1 [endoplasmic reticulum membrane] (R-HSA-191369)	0.556	3
UniProt:Q96AA3 RFT1	2	RFT1 R67C [endoplasmic reticulum membrane] (R-HSA-4570578) RFT1 [endoplasmic reticulum membrane] (R-HSA-449255)	0.556	3
UniProt:Q9H2C2 ARV1	1	ARV1 [endoplasmic reticulum membrane] (R-HSA-5216144)	0.556	3
UniProt:P27449 ATP6V0C	7	ATP6V0C [endosome membrane] (R-HSA-912591) ATP6V0C [tertiary granule membrane] (R-HSA-6800991) ATP6V0C [plasma membrane] (R-HSA-6806254) ATP6V0C [ficolin-1-rich granule membrane] (R-HSA-6800908) ATP6V0C [azurophil granule membrane] (R-HSA-6799363) ATP6V0C [phagocytic vesicle membrane] (R-HSA-1222603) ATP6V0C [lysosomal membrane] (R-HSA-9640194)	0.556	3
UniProt:O76024 WFS1	3	WFS1 [endoplasmic reticulum lumen] (R-HSA-8956747) p-WFS1 [endoplasmic reticulum lumen] (R-HSA-8956998) WFS1 [endoplasmic reticulum membrane] (R-HSA-535474)	0.556	3
UniProt:Q8N0U8 VKORC1L1	1	VKORC1L1 [endoplasmic reticulum membrane] (R-HSA-2980944)	0.556	3
UniProt:P48449 LSS	1	LSS [endoplasmic reticulum membrane] (R-HSA-191371)	0.556	3
UniProt:Q8N661 TMEM86B	1	TMEM86B [endoplasmic reticulum membrane] (R-HSA-8874443)	0.556	3
UniProt:P18031 PTPN1	2	PTPN1 [cytosol] (R-HSA-210625) PTPN1 [endosome membrane] (R-HSA-9815895)	0.556	3
UniProt:O14653 GOSR2	4	GOSR2 [endoplasmic reticulum membrane] (R-HSA-5689451) GOSR2 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-535472) GOSR2 [ER to Golgi transport vesicle membrane] (R-HSA-5689800) GOSR2 [Golgi membrane] (R-HSA-6807755)	0.556	3
UniProt:Q969S0 SLC35B4	1	SLC35B4 [Golgi membrane] (R-HSA-742365)	0.556	3
UniProt:Q8IVQ6 ZDHHC21	1	ZDHHC21 [Golgi membrane] (R-HSA-203757)	0.556	3
UniProt:P09601 HMOX1	4	HMOX1 [nucleoplasm] (R-HSA-9708567) HMOX1 [mitochondrial outer membrane] (R-HSA-9708524) HMOX1 [endoplasmic reticulum membrane] (R-HSA-189395) HMOX1 [cytosol] (R-HSA-9609901)	0.556	3
UniProt:O75396 SEC22B	6	SEC22B [endoplasmic reticulum membrane] (R-HSA-5688150) SEC22B [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688566) SEC22B [ER to Golgi transport vesicle membrane] (R-HSA-5688565) SEC22B [phagocytic vesicle membrane] (R-HSA-8863938) SEC22B [transport vesicle] (R-HSA-6810994) SEC22B [Golgi membrane] (R-HSA-6810993)	0.556	3
UniProt:P01350 GAST	1	GAST(76-92) [extracellular region] (R-HSA-870266)	0.556	3
UniProt:P07204 THBD	1	THBD [plasma membrane] (R-HSA-141030)	0.556	3
UniProt:Q8IY26 PLPP6	1	PLPP6 [plasma membrane] (R-HSA-8952144)	0.556	3
UniProt:Q92504 SLC39A7	1	SLC39A7 [endoplasmic reticulum membrane] (R-HSA-442363)	0.556	3
UniProt:Q6ZNB7 AGMO	1	AGMO [endoplasmic reticulum membrane] (R-HSA-5696124)	0.556	3
UniProt:Q9Y6X1 SERP1	2	SERP1 [endoplasmic reticulum membrane] (R-HSA-381045) SERP1 [cytosol] (R-HSA-5250574)	0.556	3
UniProt:Q8IWU4 SLC30A8	2	SLC30A8 [Golgi membrane] (R-HSA-9817561) SLC30A8 [secretory granule membrane] (R-HSA-437106)	0.556	3
UniProt:P50281 MMP14	3	MMP14(21-582) [Golgi lumen] (R-HSA-1604689) MMP14 [Golgi lumen] (R-HSA-1604724) MMP14 [plasma membrane] (R-HSA-1442472)	0.556	3
UniProt:P63027 VAMP2	20	VAMP2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869129) VAMP2 [clathrin-sculpted monoamine transport vesicle membrane] (R-HSA-379363) VAMP2 [plasma membrane] (R-HSA-210516) VAMP2 [clathrin-sculpted gamma-aminobutyric acid transport vesicle membrane] (R-HSA-917738) VAMP2 [clathrin-sculpted glutamate transport vesicle membrane] (R-HSA-210365) VAMP2 [synaptic vesicle membrane] (R-HSA-181517) VAMP2(59-116) [synaptic vesicle membrane] (R-HSA-5250891) VAMP2(2-58) [cytosol] (R-HSA-194815) VAMP2(2-76) [cytosol] (R-HSA-194802) VAMP2(77-116) [synaptic vesicle membrane] (R-HSA-5228355) VAMP2(60-116) [synaptic vesicle membrane] (R-HSA-5250615) VAMP2(2-59) [cytosol] (R-HSA-194797) VAMP2(82-116) [synaptic vesicle membrane] (R-HSA-5250961) VAMP2(2-81) [cytosol] (R-HSA-5250970) VAMP2 [secretory granule membrane] (R-HSA-376363) VAMP2 [cytosol] (R-HSA-9609882) VAMP2 [endoplasmic reticulum membrane] (R-HSA-9609886) VAMP2 [cytoplasmic vesicle membrane] (R-HSA-1449630) VAMP2 [lysosomal membrane] (R-HSA-432703) VAMP2 [Golgi membrane] (R-HSA-375425)	0.556	3
UniProt:P30825 SLC7A1	1	SLC7A1 [plasma membrane] (R-HSA-375771)	0.556	3
UniProt:Q9NTJ5 SACM1L	2	SACM1L [endoplasmic reticulum membrane] (R-HSA-1604637) SACM1L [Golgi membrane] (R-HSA-1806242)	0.556	3
UniProt:P29033 GJB2	3	GJB2 [plasma membrane] (R-HSA-53211) GJB2 [endoplasmic reticulum membrane] (R-HSA-1629779) GJB2 [endoplasmic reticulum-Golgi intermediate compartment] (R-HSA-190614)	0.556	3
UniProt:Q5QGT7 RTP2	2	RTP2 [endoplasmic reticulum membrane] (R-HSA-9752982) RTP2 [plasma membrane] (R-HSA-8939446)	0.556	3
UniProt:Q9H2H9 SLC38A1	1	SLC38A1 [plasma membrane] (R-HSA-212663)	0.556	3
UniProt:P02652 APOA2	6	APOA2(24-100) [cytosol] (R-HSA-2395772) APOA2(24-100) [early endosome] (R-HSA-2569092) APOA2(24-100) [endoplasmic reticulum lumen] (R-HSA-174689) APOA2(24-100) [extracellular region] (R-HSA-174775) p-APOA2 [endoplasmic reticulum lumen] (R-HSA-8957014) APOA2 [endoplasmic reticulum lumen] (R-HSA-8956780)	0.556	3
UniProt:Q15836 VAMP3	6	VAMP3 [recycling endosome membrane] (R-HSA-2029063) VAMP3 [phagocytic vesicle membrane] (R-HSA-2029013) VAMP3 [plasma membrane] (R-HSA-8867599) VAMP3 [trans-Golgi network membrane] (R-HSA-6814624) VAMP3 [transport vesicle] (R-HSA-6814625) VAMP3 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869130)	0.556	3
UniProt:Q9BRI3 SLC30A2	2	SLC30A2 [endosome membrane] (R-HSA-435363) SLC30A2 [synaptic vesicle membrane] (R-HSA-4084714)	0.556	3
UniProt:Q9Y5Q5 CORIN	1	CORIN(802-1042) [plasma membrane] (R-HSA-5490311)	0.556	3
UniProt:O95406 CNIH1	3	CNIH1 [endoplasmic reticulum membrane] (R-HSA-5689439) CNIH1 [ER to Golgi transport vesicle membrane] (R-HSA-5689776) CNIH1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5689778)	0.556	3
UniProt:Q01628 IFITM3	1	IFITM3 [plasma membrane] (R-HSA-1015688)	0.556	3
UniProt:Q9Y5Y5 PEX16	2	PEX16 [peroxisomal membrane] (R-HSA-9603805) PEX16 [cytosol] (R-HSA-9603790)	0.556	3
UniProt:P24593 IGFBP5	5	IGFBP5 [extracellular region] (R-HSA-381414) IGFBP5(21-163) [extracellular region] (R-HSA-381415) IGFBP5(164-272) [extracellular region] (R-HSA-381478) IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956738) p-IGFBP5 [endoplasmic reticulum lumen] (R-HSA-8956988)	0.556	3
UniProt:O00767 SCD	1	SCD [endoplasmic reticulum membrane] (R-HSA-400117)	0.556	3
UniProt:Q96BZ9 TBC1D20	1	TBC1D20 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-6814813)	0.556	3
UniProt:Q13277 STX3	1	STX3 [plasma membrane] (R-HSA-449131)	0.556	3
UniProt:O75379 VAMP4	4	VAMP4 [transport vesicle] (R-HSA-6811023) VAMP4 [trans-Golgi network membrane] (R-HSA-6811021) VAMP4 [plasma membrane] (R-HSA-8864461) VAMP4 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869133)	0.556	3
UniProt:Q15848 ADIPOQ	1	ADIPOQ [extracellular region] (R-HSA-1183052)	0.556	3
UniProt:Q9NRZ7 AGPAT3	2	AGPAT3 [Golgi membrane] (R-HSA-8849239) AGPAT3 [endoplasmic reticulum membrane] (R-HSA-61807)	0.556	3
UniProt:Q8WVV5 BTN2A2	1	BTN2A2 [plasma membrane] (R-HSA-8851047)	0.556	3
UniProt:P78382 SLC35A1	2	SLC35A1 [Golgi membrane] (R-HSA-727812) SLC35A1 V93Cfs*17 [Golgi membrane] (R-HSA-5651957)	0.556	3
UniProt:P01031 C5	7	C5(965-1676) [extracellular region] (R-HSA-8852713) C5aT [extracellular region] (R-HSA-8852711) C5a-desArg [extracellular region] (R-HSA-8852798) C5b alpha' [extracellular region] (R-HSA-173672) C5 alpha chain [extracellular region] (R-HSA-173673) C5 beta chain [extracellular region] (R-HSA-173675) C5a [extracellular region] (R-HSA-173677)	0.556	3
UniProt:P81534 DEFB103A	3	DEFB103A(23-67) [extracellular region] (R-HSA-1467273) DEFB103A(23-67) [Golgi lumen] (R-HSA-1467243) DEFB103A(1-67) [Golgi lumen] (R-HSA-975669)	0.556	3
UniProt:Q9NZ43 USE1	1	USE1 [endoplasmic reticulum membrane] (R-HSA-2193119)	0.556	3
UniProt:Q12893 TMEM115	1	TMEM115 [Golgi membrane] (R-HSA-6808815)	0.556	3
UniProt:Q7L5A8 FA2H	1	FA2H [endoplasmic reticulum membrane] (R-HSA-5693771)	0.556	3
UniProt:O75106 AOC2	1	AOC2 [plasma membrane] (R-HSA-5696150)	0.556	3
UniProt:Q13190 STX5	5	STX5 [endoplasmic reticulum membrane] (R-HSA-5689474) STX5 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688157) STX5 [ER to Golgi transport vesicle membrane] (R-HSA-5689838) STX5 [Golgi membrane] (R-HSA-6807771) STX5 [cytosol] (R-HSA-9613991)	0.556	3
UniProt:Q15125 EBP	1	EBP [endoplasmic reticulum membrane] (R-HSA-195697)	0.556	3
UniProt:O15155 BET1	3	BET1 [endoplasmic reticulum-Golgi intermediate compartment membrane] (R-HSA-5688142) BET1 [Golgi membrane] (R-HSA-6807743) BET1 [transport vesicle] (R-HSA-6808719)	0.556	3
UniProt:Q6ZPD8 DGAT2L6	1	DGAT2L6 [endoplasmic reticulum membrane] (R-HSA-8848588)	0.556	3