Reactome | ADAM12 [plasma membrane]

ADAM12 [plasma membrane]

Stable Identifier

R-HSA-179792

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

ADAM 12 metalloprotease, ADAM 12 sheddase

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O43184 ADAM12

Gene Names

ADAM12, MLTN, UNQ346/PRO545

Chain

signal peptide:1-28, propeptide:29-207, chain:208-909

Reference Genes

BioGPS Gene:8038 ADAM12

COSMIC (genes):ADAM12 ADAM12

CTD Gene:8038 ADAM12

dbSNP Gene:8038 ADAM12

ENSEMBL:ENSG00000148848 ADAM12

ENSEMBL:ENSG00000148848.15 ADAM12

HGNC:190 ADAM12

KEGG Gene (Homo sapiens):8038 ADAM12

Monarch:8038 ADAM12

NCBI Gene:8038 ADAM12

OMIM:602714 ADAM12

UCSC:O43184 ADAM12

Reference Transcript

Other Identifiers

11716605_at

11722199_at

11722200_s_at

11747432_a_at

11757460_s_at

16719417

17126208

17126212

202952_PM_s_at

202952_s_at

204943_PM_at

204943_at

213790_PM_at

213790_at

226777_PM_at

226777_at

3311833

3311834

3311835

3311836

3311837

3311838

3311839

3311843

3311844

3311848

3311850

3311852

3311853

3311854

3311856

3311859

3311860

3311861

3311870

3311873

3311878

3311894

3311901

3311903

3311904

3311913

3311914

3311918

3311931

3311939

3311955

3311973

3311987

3311988

38769_at

38770_at

55567_at

7936968

8038

A_23_P202327

A_23_P350512

A_33_P3256848

A_33_P3310929

GE54183

GO:0003824

GO:0004222

GO:0005515

GO:0005576

GO:0005634

GO:0005654

GO:0005886

GO:0006508

GO:0007155

GO:0007520

GO:0008233

GO:0008237

GO:0016020

GO:0016787

GO:0017124

GO:0030154

GO:0043226

GO:0045766

GO:0046872

GO:0048856

GO:0140096

HMNXSV003009360

HMNXSV003052096

Hs.8850.2.A1_3p_at

Hs.8895.0.A1_3p_at

ILMN_1705689

ILMN_1726266

ILMN_1785393

PH_hs_0000933

TC10001744.hg

TC10002885.hg

g11496999_3p_at

g13259517_3p_a_at

p28910

Participates

as a member of

Inferred To

ADAM12 [plasma membrane] (Canis familiaris)

ADAM12 [plasma membrane] (Danio rerio)

ADAM12 [plasma membrane] (Gallus gallus)

ADAM12 [plasma membrane] (Mus musculus)

ADAM12 [plasma membrane] (Rattus norvegicus)

ADAM12 [plasma membrane] (Schizosaccharomyces pombe)

ADAM12 [plasma membrane] (Sus scrofa)

ADAM12 [plasma membrane] (Xenopus tropicalis)

Cross References

RefSeq

NP_001275904.1, NP_067673.2, NP_003465.3, NP_001275903.1

Guide to Pharmacology - Targets

1660

OpenTargets

ENSG00000148848

HPA

ENSG00000148848-ADAM12

GeneCards

O43184

ZINC - Substances

ADA12_HUMAN

ZINC target

O43184

Ensembl

ENST00000368679, ENSP00000357668, ENST00000368676, ENSG00000148848, ENSP00000357665

PRO

O43184

Pharos - Targets

O43184

ZINC - Predictions - Purchasable

ADA12_HUMAN

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07948 LYN	7	MyrG2-PalmC3-LYN [lysosomal membrane] (R-HSA-9707903) MyrG2-PalmC3-LYN [endocytic vesicle membrane] (R-HSA-9705728) LYN [plasma membrane] (R-HSA-197943) p-Y397-LYN [cytosol] (R-HSA-8942608) p-Y397-LYN [plasma membrane] (R-HSA-2454229) LYN [cytosol] (R-HSA-354251) MyrG2-PalmC3-LYN [plasma membrane] (R-HSA-9606875)	0.558	2
UniProt:P12931 SRC	6	SRC [cytosol] (R-HSA-9628701) p-Y419-SRC [cytosol] (R-HSA-8964276) p-Y419-SRC [nucleoplasm] (R-HSA-8937690) MyrG-SRC [plasma membrane] (R-HSA-8876922) MyrG,p-Y530-SRC [plasma membrane] (R-HSA-377598) MyrG-p-Y419-SRC [plasma membrane] (R-HSA-1810408)	0.558	2
UniProt:P08631 HCK	2	p-HCK [cytosol] (R-HSA-9676060) HCK [cytosol] (R-HSA-167708)	0.558	2
UniProt:Q5HYK7 SH3D19	1	SH3D19 [cytosol] (R-HSA-434202)	0.556	4