Reactome | LRIG1 [plasma membrane]

LRIG1 [plasma membrane]

Stable Identifier

R-HSA-197745

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

plasma membrane

Synonyms

Leucine-rich repeats and immunoglobulin-like domains protein 1 precursor, LIG1_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q96JA1 LRIG1

Gene Names

LRIG1, LIG1

Chain

signal peptide:1-34, chain:35-1093

Reference Genes

BioGPS Gene:26018 LRIG1

COSMIC (genes):LRIG1 LRIG1

CTD Gene:26018 LRIG1

dbSNP Gene:26018 LRIG1

ENSEMBL:ENSG00000144749 LRIG1

ENSEMBL_homo_sapiens_GENE:ENSG00000144749.14 LRIG1

HGNC:17360 LRIG1

KEGG Gene (Homo sapiens):26018 LRIG1

Monarch:26018 LRIG1

NCBI Gene:26018 LRIG1

OMIM:608868 LRIG1

UCSC:Q96JA1 LRIG1

Reference Transcript

RefSeq:NM_015541.2 LRIG1

Other Identifiers

11750405_a_at

11755110_a_at

16955939

211596_PM_s_at

211596_s_at

238339_PM_x_at

238339_x_at

240140_PM_s_at

240140_s_at

26018

2680602

2680603

2680604

2680605

2680606

2680607

2680610

2680612

2680613

2680614

2680617

2680620

2680621

2680622

2680625

2680631

2680634

2680637

2680641

2680642

2680644

2680645

2680661

2680669

2680683

2680684

2680685

34800_at

63691_at

70503_at

8088642

A_23_P109636

GE56536

GO:0005515

GO:0005576

GO:0005615

GO:0005886

GO:0007605

GO:0016020

GO:0022405

GO:0030312

GO:0031012

GO:0032474

GO:0048856

GO:0050877

GO:0060384

HMNXSV003006438

Hs.121706.1.S1_3p_s_at

Hs.207432.0.A1_3p_s_at

ILMN_1707342

ILMN_2128795

PH_hs_0022789

PH_hs_0034614

TC03001532.hg

g13537354_3p_s_at

Participates

as a protein marker of

keratinocyte stem cell of skin epidermis basal layer (Homo sapiens)

as a component of

MET:LRIG1 [plasma membrane] (Homo sapiens)

as an input of

MET binds LRIG1 (Homo sapiens)

This entity regulates

Negatively

EGFR binds EGF ligand (Homo sapiens)

Other forms of this molecule

Ub-LRIG1 [plasma membrane]

Inferred To

sma-10 [plasma membrane] (Caenorhabditis elegans)

Lrig1 [plasma membrane] (Mus musculus)

Lrig1 [plasma membrane] (Rattus norvegicus)

LRIG1 [plasma membrane] (Bos taurus)

LRIG1 [plasma membrane] (Canis familiaris)

LRIG1 [plasma membrane] (Gallus gallus)

LRIG1 [plasma membrane] (Sus scrofa)

Cross References

RefSeq

NP_056356.2

OpenTargets

ENSG00000144749

HPA

ENSG00000144749-LRIG1

GeneCards

Q96JA1

Ensembl

ENSG00000144749, ENSP00000373208, ENST00000273261, ENSP00000273261, ENST00000383703

PRO

Q96JA1

Pharos - Targets

Q96JA1

PDB

4U7M, 4U7L

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04626 ERBB2	20	ERBB2 G309E [plasma membrane] (R-HSA-9665342) ERBB2 G309A [plasma membrane] (R-HSA-9665349) ERBB2 S310F [plasma membrane] (R-HSA-9665350) ERBB2 S310Y [plasma membrane] (R-HSA-9665344) p-6Y-ERBB2 G309A [plasma membrane] (R-HSA-9665381) p-6Y-ERBB2 G309E [plasma membrane] (R-HSA-9665382) p-6Y-ERBB2 S310F [plasma membrane] (R-HSA-9665379) p-6Y-ERBB2 S310Y [plasma membrane] (R-HSA-9665385) p-Y-ERBB2 L755P [plasma membrane] (R-HSA-9654268) p-Y-ERBB2 I767M [plasma membrane] (R-HSA-9654303) p-Y-ERBB2 T798I [plasma membrane] (R-HSA-9654618) p-Y-ERBB2 Y772_A775dup [plasma membrane] (R-HSA-9665652) p-Y-ERBB2 T862A [plasma membrane] (R-HSA-9654695) p-Y-ERBB2 T798M [plasma membrane] (R-HSA-9654615) p-Y-ERBB2 H878Y [plasma membrane] (R-HSA-9654833) p-Y-ERBB2 V777L [plasma membrane] (R-HSA-9654401) p-Y-ERBB2 L755S [plasma membrane] (R-HSA-9654194) p-Y-ERBB2 V777E [plasma membrane] (R-HSA-9654397) p-Y-ERBB2 V777M [plasma membrane] (R-HSA-9654398) p-Y-ERBB2 L755M [plasma membrane] (R-HSA-9654191)	0.748	7
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.743	6
UniProt:Q6UXM1 LRIG3			0.641	9
UniProt:Q15303 ERBB4			0.589	3
UniProt:Q9H9A6 LRC40			0.527	2
UniProt:Q99999 GAL3ST1	1	GAL3ST1 [Golgi membrane] (R-HSA-1631586)	0.527	3
UniProt:Q8WVQ1 CANT1	4	CANT1 [specific granule lumen] (R-HSA-6799706) CANT1 [ficolin-1-rich granule lumen] (R-HSA-6800998) CANT1 [extracellular region] (R-HSA-6800464) CANT1 [tertiary granule lumen] (R-HSA-6800976)	0.527	2
UniProt:Q99445 GML			0.527	2
UniProt:P13747 HLA-E	7	HLA class I histocompatibility antigen, E alpha chain precursor [phagocytic vesicle membrane] (R-HSA-1236793) HLA class I histocompatibility antigen, E alpha chain precursor [recycling endosome membrane] (R-HSA-8863974) HLA class I histocompatibility antigen, E alpha chain precursor [early endosome membrane] (R-HSA-1236744) HLA class I histocompatibility antigen, E alpha chain precursor [Golgi membrane] (R-HSA-983339) HLA class I histocompatibility antigen, E alpha chain precursor [ER to Golgi transport vesicle membrane] (R-HSA-983407) HLA class I histocompatibility antigen, E alpha chain precursor [lumenal side of endoplasmic reticulum membrane] (R-HSA-983090) HLA class I histocompatibility antigen, E alpha chain precursor [plasma membrane] (R-HSA-197643)	0.527	2
UniProt:Q3ZCM7 TUBB8	3	Polyglycyl-TUBB8 [cytosol] (R-HSA-8867423) Polyglutamyl-TUBB8 [cytosol] (R-HSA-8867387) TUBB8 [cytosol] (R-HSA-6805243)	0.527	2
UniProt:O94898 LRIG2			0.527	3
UniProt:P20338 RAB4A	5	GGC-RAB4A [cytoplasmic vesicle membrane] (R-HSA-1458526) GGC-RAB4A [cytosol] (R-HSA-8874045) RAB4A [cytosol] (R-HSA-8873709) RAB4A [early endosome membrane] (R-HSA-8871356) GGC-RAB4A [recycling endosome membrane] (R-HSA-8875666)	0.527	2
UniProt:Q9BT09 CNPY3	1	CNPY3 [endoplasmic reticulum lumen] (R-HSA-1678932)	0.527	3
UniProt:P22681 CBL	20	PolyUb,p-Y-CBL [cytosol] (R-HSA-9763893) CBL R420G [cytosol] (R-HSA-9706203) CBL R420Q [cytosol] (R-HSA-9706186) CBL Y371H [cytosol] (R-HSA-9706680) CBL H398Y [cytosol] (R-HSA-9706639) CBL P417A [cytosol] (R-HSA-9706636) CBL S376F [cytosol] (R-HSA-9706643) CBL E366_Q409del [cytosol] (R-HSA-9706179) CBL del366-477 [cytosol] (R-HSA-9706176) CBL R499L [cytosol] (R-HSA-9706678) CBL L380P [cytosol] (R-HSA-9706630) CBL L287R [cytosol] (R-HSA-9706693) CBL L380R [cytosol] (R-HSA-9706635) CBL G375P [cytosol] (R-HSA-9706219) CBL P417L [cytosol] (R-HSA-9706634) CBL H398Q [cytosol] (R-HSA-9706633) CBL P417R [cytosol] (R-HSA-9706632) CBL R499* [cytosol] (R-HSA-9706670) CBL H398R [cytosol] (R-HSA-9706638) CBL H398P [cytosol] (R-HSA-9706637)	0.524	2
UniProt:Q9UPQ0-1 LIMCH1			0.463	2
UniProt:P00533-4 EGFR			0.463	2
UniProt:Q8WWI1-3 LMO7			0.463	2

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