Reactome | DUSP4 [nucleoplasm]

DUSP4 [nucleoplasm]

Stable Identifier

R-HSA-203794

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Dual specificity protein phosphatase 4, DUS4_HUMAN

Locations in the PathwayBrowser

Expand all

Immune System (Homo sapiens)

- Cytokine Signaling in Immune system (Homo sapiens)
  - Signaling by Interleukins (Homo sapiens)
    - Interleukin-17 signaling (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP4 [nucleoplasm] (Homo sapiens)
- Innate Immune System (Homo sapiens)
  - Toll-like Receptor Cascades (Homo sapiens)
    - Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP4 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
      - Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP4 [nucleoplasm] (Homo sapiens)
      - Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
        
        MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP4 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
      - MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP4 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
      - MyD88-independent TLR4 cascade (Homo sapiens)
        
        TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP4 [nucleoplasm] (Homo sapiens)
      - MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP4 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
      - MyD88 cascade initiated on plasma membrane (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP4 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP4 [nucleoplasm] (Homo sapiens)
    - Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
      - MyD88 dependent cascade initiated on endosome (Homo sapiens)
        
        TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
        
        MAP kinase activation (Homo sapiens)
        
        MAPK targets/ Nuclear events mediated by MAP kinases (Homo sapiens)
        
        ERK/MAPK targets (Homo sapiens)
        
        ERKs are inactivated (Homo sapiens)
        
        ERKs are inactivated by dual-specific phosphatases (DUSPs) (Homo sapiens)
        
        ERK-specific DUSP [nucleoplasm] (Homo sapiens)
        
        DUSP4 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q13115 DUSP4

Gene Names

DUSP4, MKP2, VH2

Chain

initiator methionine:, chain:2-394

Reference Genes

BioGPS Gene:1846 DUSP4

COSMIC (genes):DUSP4 DUSP4

CTD Gene:1846 DUSP4

dbSNP Gene:1846 DUSP4

ENSEMBL:ENSG00000120875 DUSP4

ENSEMBL_homo_sapiens_GENE:ENSG00000120875.9 DUSP4

HGNC:3070 DUSP4

KEGG Gene (Homo sapiens):1846 DUSP4

Monarch:1846 DUSP4

NCBI Gene:1846 DUSP4

OMIM:602747 DUSP4

UCSC:Q13115 DUSP4

Reference Transcript

Other Identifiers

11744162_a_at

17075973

1788_s_at

1846

204014_PM_at

204014_at

204015_PM_s_at

204015_s_at

226034_PM_at

226034_at

3129730

3129732

3129733

3129734

3129735

3129736

3129737

3129739

3129743

3129744

3129747

3129748

3129749

3129750

3129751

3129752

3129753

3129754

3129755

8150076

90732_at

A_23_P134935

GE56786

GO:0001706

GO:0003824

GO:0004721

GO:0004722

GO:0004725

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0006470

GO:0008138

GO:0008330

GO:0016311

GO:0016787

GO:0016791

GO:0017017

GO:0017018

GO:0023052

GO:0033550

GO:0036211

GO:0043226

GO:0043409

GO:0048856

GO:0070373

GO:0140096

GO:1990439

HMNXSV003007622

Hs.166975.4.S1_3p_at

ILMN_1808391

ILMN_2283398

PH_hs_0016719

PH_hs_0025078

TC08001099.hg

TC08002271.hg

U48807_at

g12707552_3p_at

g12803670_3p_a_at

Participates

as a candidate of

nuclear MAPK DUSPs [nucleoplasm] (Homo sapiens)

as a member of

ERK-specific DUSP [nucleoplasm] (Homo sapiens)

Inferred To

Homologues of DUSP4 [nucleoplasm] (Dictyostelium discoideum)

zgc:55423 [nucleoplasm] (Danio rerio)

mpl2 [nucleoplasm] (Dictyostelium discoideum)

mpl1 [nucleoplasm] (Dictyostelium discoideum)

DUSP4 [nucleoplasm] (Bos taurus)

DUSP4 [nucleoplasm] (Canis familiaris)

DUSP4 [nucleoplasm] (Dictyostelium discoideum)

DUSP4 [nucleoplasm] (Gallus gallus)

DUSP4 [nucleoplasm] (Plasmodium falciparum)

DUSP4 [nucleoplasm] (Sus scrofa)

dusp4 [nucleoplasm] (Xenopus tropicalis)

Dusp4 [nucleoplasm] (Mus musculus)

Dusp4 [nucleoplasm] (Rattus norvegicus)

mpl3 [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_476499.1, NP_001385.1, XP_011542730.1

OpenTargets

ENSG00000120875

ZINC - Substances

DUS4_HUMAN

ZINC target

Q13115

PRO

Q13115

PDB

3EZZ

IntEnz

3.1.3.48

GeneCards

Q13115

HPA

ENSG00000120875-DUSP4

Ensembl

ENST00000240101, ENSG00000120875, ENSP00000240100, ENSP00000240101, ENST00000240100

Pharos - Targets

Q13115

ZINC - Predictions - Purchasable

DUS4_HUMAN

HMDB Protein

HMDBP08911

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P28482 MAPK1	18	MAPK1 [endoplasmic reticulum lumen] (R-HSA-9636293) MAPK1 [azurophil granule lumen] (R-HSA-6799225) MAPK1 [extracellular region] (R-HSA-6806250) MAPK1 [ficolin-1-rich granule lumen] (R-HSA-6800964) p-T185,Y187 MAPK1 E322V [cytosol] (R-HSA-9652797) p-T185,Y187 MAPK1 E322K [cytosol] (R-HSA-9652175) p-T185,Y187 MAPK1 E81K [cytosol] (R-HSA-9652799) p-T185,Y187 MAPK1 S142L [cytosol] (R-HSA-9652808) p-T185,Y187 MAPK1 P58L [cytosol] (R-HSA-9652806) p-T185,Y187 MAPK1 D321V [cytosol] (R-HSA-9652791) p-T185,Y187 MAPK1 D321N [cytosol] (R-HSA-9652785) p-T185,Y187 MAPK1 E322A [cytosol] (R-HSA-9652794) p-T185,Y187 MAPK1 P58G [cytosol] (R-HSA-9652802) p-T185-MAPK1 [cytosol] (R-HSA-9635773) MAPK1 [nucleoplasm] (R-HSA-199960) MAPK1 [cytosol] (R-HSA-59282) p-T185,Y187-MAPK1 [cytosol] (R-HSA-109853) p-T185,Y187-MAPK1 [nucleoplasm] (R-HSA-112354)	0.806	6
UniProt:Q13077 TRAF1	3	TRAF1 [cytosol] (R-HSA-5634163) TRAF1(1-163) [cytosol] (R-HSA-5634199) TRAF1(164-416) [cytosol] (R-HSA-5634204)	0.556	3

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