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ACVR1B [plasma membrane]
Stable Identifier
R-HSA-205867
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
ALK4
Locations in the PathwayBrowser
Expand all
Developmental Biology (Homo sapiens)
Signaling by NODAL (Homo sapiens)
Regulation of signaling by NODAL (Homo sapiens)
LEFTY binds the EGF-CFC coreceptor in the NODAL receptor (Homo sapiens)
LEFTY1,2:NODAL Receptor [plasma membrane] (Homo sapiens)
NODAL Receptor [plasma membrane] (Homo sapiens)
ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1B [plasma membrane] (Homo sapiens)
NODAL Receptor [plasma membrane] (Homo sapiens)
ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1B [plasma membrane] (Homo sapiens)
The NODAL Receptor binds NODAL ligands (Homo sapiens)
NODAL Ligand:NODAL Receptor [plasma membrane] (Homo sapiens)
NODAL Receptor [plasma membrane] (Homo sapiens)
ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1B [plasma membrane] (Homo sapiens)
NODAL Receptor [plasma membrane] (Homo sapiens)
ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1B [plasma membrane] (Homo sapiens)
Type II Activin Receptor (ActRII/ACVR2) phosphorylates Type I Activin Receptor (ActRIB/ACVR1B) in response to NODAL (Homo sapiens)
NODAL:ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
ACVR1B [plasma membrane] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by TGFB family members (Homo sapiens)
Signaling by Activin (Homo sapiens)
ACVR2A,B (ActRIIA,B) phosphorylates ACVR1B (ActRIB, ALK4) in response to Activin (Homo sapiens)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Homo sapiens)
ACVR1B [plasma membrane] (Homo sapiens)
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Homo sapiens)
ACVR1B [plasma membrane] (Homo sapiens)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Homo sapiens)
ACVR1B [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:P36896 ACVR1B
Gene Names
ACVR1B, ACVRLK4, ALK4
Chain
signal peptide:1-23, chain:24-505
Reference Genes
BioGPS Gene:91 ACVR1B
COSMIC (genes):ACVR1B ACVR1B
CTD Gene:91 ACVR1B
dbSNP Gene:91 ACVR1B
ENSEMBL:ENSG00000135503 ACVR1B
ENSEMBL_homo_sapiens_GENE:ENSG00000135503.13 ACVR1B
HGNC:172 ACVR1B
KEGG Gene (Homo sapiens):91 ACVR1B
Monarch:91 ACVR1B
NCBI Gene:91 ACVR1B
OMIM:601300 ACVR1B
UCSC:P36896 ACVR1B
Reference Transcript
RefSeq:NM_020327.3 ACVR1B
RefSeq:NM_020328.3 ACVR1B
RefSeq:NM_004302.4 ACVR1B
Other Identifiers
11720437_at
11720438_a_at
11720439_at
11738852_a_at
11738855_a_at
16751401
205209_PM_at
205209_at
208218_PM_s_at
208218_s_at
208219_PM_at
208219_at
208222_PM_at
208222_at
208223_PM_s_at
208223_s_at
213198_PM_at
213198_at
34055_at
34056_g_at
3415149
3415150
3415152
3415163
3415164
3415165
3415168
3415171
3415172
3415174
3415175
3415176
3415177
3415179
3415180
3415181
3415183
3415184
3415185
3415186
3415188
34415_at
36451_at
75350_at
7955535
91
921_s_at
A_14_P100704
A_14_P102652
A_14_P125289
A_23_P99036
A_24_P341897
A_33_P3364433
GE56528
GE60369
GE850363
GO:0000082
GO:0000166
GO:0000278
GO:0001701
GO:0001942
GO:0002376
GO:0003824
GO:0004672
GO:0004674
GO:0004675
GO:0005515
GO:0005524
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006468
GO:0007165
GO:0007178
GO:0007399
GO:0009966
GO:0009986
GO:0010628
GO:0010629
GO:0012501
GO:0016020
GO:0016301
GO:0016310
GO:0016361
GO:0016740
GO:0017002
GO:0018107
GO:0019838
GO:0022414
GO:0023052
GO:0030154
GO:0030308
GO:0031625
GO:0032924
GO:0032927
GO:0034711
GO:0036211
GO:0038092
GO:0043167
GO:0043235
GO:0045648
GO:0046332
GO:0046777
GO:0046872
GO:0048179
GO:0048185
GO:0048856
GO:0048870
GO:0051171
GO:0060089
GO:0060255
GO:0070411
GO:0071363
GO:0097191
GO:0098802
GO:0140096
GO:0141091
GO:1901165
HMNXSV003010958
Hs.5288.0.S1_3p_at
ILMN_1763916
ILMN_1766723
ILMN_1786544
ILMN_2243308
PH_hs_0024200
TC12000411.hg
Z22536_at
g10862691_3p_at
g10862693_3p_at
g12652986_3p_at
Participates
as a component of
Nodal:Nodal Receptor (human-mouse chimera) [plasma membrane] (Homo sapiens)
ACVR1B:ACVR2A,B:EGF-CFC [plasma membrane] (Homo sapiens)
Activin A,AB,B:ACVR2A,B:ACVR1B [plasma membrane] (Homo sapiens)
as an input of
Activin A,AB,B binds Activin Receptor ACVR2A,B:ACVR1B (Homo sapiens)
Other forms of this molecule
p-4S,T188,T206-ACVR1B [plasma membrane]
Inferred To
Acvr1b [plasma membrane]
(Mus musculus)
ACVR1B [plasma membrane]
(Bos taurus)
ACVR1B [plasma membrane]
(Caenorhabditis elegans)
ACVR1B [plasma membrane]
(Canis familiaris)
ACVR1B [plasma membrane]
(Drosophila melanogaster)
ACVR1B [plasma membrane]
(Gallus gallus)
ACVR1B [plasma membrane]
(Rattus norvegicus)
ACVR1B [plasma membrane]
(Sus scrofa)
ACVR1B [plasma membrane]
(Xenopus tropicalis)
Ghost homologue of ACVR1B [plasma membrane]
(Danio rerio)
Cross References
RefSeq
NP_004293.1
,
NP_064732.3
,
NP_064733.3
ZINC - World Drugs
ACV1B_HUMAN
Guide to Pharmacology - Targets
1787
OpenTargets
ENSG00000135503
ZINC - FDA approved
ACV1B_HUMAN
ZINC - Substances
ACV1B_HUMAN
ZINC - Biogenic
ACV1B_HUMAN
ZINC target
P36896
PRO
P36896
PDB
7OLY
,
7MRZ
ZINC - Investigational
ACV1B_HUMAN
IntEnz
2.7.11.30
HPA
ENSG00000135503-ACVR1B
GeneCards
P36896
Ensembl
ENST00000426655
,
ENSP00000257963
,
ENSP00000442656
,
ENST00000541224
,
ENSP00000397550
,
ENST00000415850
,
ENSP00000442885
,
ENSP00000390477
,
ENST00000257963
,
ENSG00000135503
,
ENST00000542485
Pharos - Targets
P36896
ZINC - Predictions - Purchasable
ACV1B_HUMAN
HMDB Protein
HMDBP01407
Interactors (4)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:O15105 SMAD7
2
SMAD7 [nucleoplasm]
(R-HSA-178197)
SMAD7 [cytosol]
(R-HSA-173478)
0.524
3
UniProt:P08238 HSP90AB1
6
HSP90AB1 [secretory granule lumen]
(R-HSA-6801477)
HSP90AB1 [extracellular region]
(R-HSA-6806463)
HSP90AB1 [ficolin-1-rich granule lumen]
(R-HSA-6801491)
HSP90AB1 [cytosol]
(R-HSA-419617)
HSP90AB1 [nucleoplasm]
(R-HSA-5082399)
HSP90AB1 [lysosomal lumen]
(R-HSA-9622846)
0.524
2
UniProt:P62942 FKBP1A
1
FKBP1A [cytosol]
(R-HSA-2026007)
0.508
2
UniProt:P27040 Acvr2b
2
Acvr2b (ActRIIB) [plasma membrane]
(R-MMU-1181124)
ACVR2B [plasma membrane]
(R-MMU-201656)
0.499
4
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