Reactome | Initiation of Nuclear Envelope (NE) Reformation

Initiation of Nuclear Envelope (NE) Reformation

Stable Identifier

R-HSA-2995383

DOI

10.3180/R-HSA-2995383.4

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

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Cell Cycle (Homo sapiens)

- Cell Cycle, Mitotic (Homo sapiens)
  - M Phase (Homo sapiens)
    - Mitotic Metaphase and Anaphase (Homo sapiens)
      - Mitotic Anaphase (Homo sapiens)
        
        Nuclear Envelope (NE) Reassembly (Homo sapiens)
        
        Initiation of Nuclear Envelope (NE) Reformation (Homo sapiens)

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Initiation of Nuclear Envelope (NE) Reformation

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Reassembly of the nuclear envelope (NE) is initiated at late anaphase/early telophase when BANF1 (BAF), which is dispersed throughout the cytoplasm during metaphase, accumulates on the surfaces of coalesced chromosomes. This is coordinated with the chromatin association of membranes and inner nuclear membrane proteins that include EMD (emerin), TMPO (LAP2beta), LEMD3 (MAN1) and LEMD2 (LEM2), and lamins (Haraguchi et al. 2008, reviewed by Wandke and Kutay 2013). The DNA-cross-bridging activity of BANF1 is required for individual chromosomes to properly coalesce for enclosure in a single nucleus (Samwer et al. 2017).

Literature References

PubMed ID	Title	Journal	Year
23498932	Enclosing chromatin: reassembly of the nucleus after open mitosis Wandke, C, Kutay, U	Cell	2013
18628300	Live cell imaging and electron microscopy reveal dynamic processes of BAF-directed nuclear envelope assembly Haraguchi, T, Kojidani, T, Koujin, T, Shimi, T, Osakada, H, Mori, C, Yamamoto, A, Hiraoka, Y	J. Cell. Sci.	2008
28841419	DNA Cross-Bridging Shapes a Single Nucleus from a Set of Mitotic Chromosomes Samwer, M, Schneider, MWG, Hoefler, R, Schmalhorst, PS, Jude, JG, Zuber, J, Gerlich, DW	Cell	2017