Reactome | SMYD2 [nucleoplasm]

SMYD2 [nucleoplasm]

Stable Identifier

R-HSA-3222233

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

N-lysine methyltransferase SMYD2, HSKM-B, Histone methyltransferase SMYD2, Lysine N-methyltransferase 3C, SET and MYND domain-containing protein 2, KMT3C

Locations in the PathwayBrowser

Expand all

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by TP53 (Homo sapiens)
      - Regulation of TP53 Activity (Homo sapiens)
        
        Regulation of TP53 Activity through Methylation (Homo sapiens)
        
        SMYD2 methylates TP53 (Homo sapiens)
        
        SMYD2 [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q9NRG4 SMYD2

Gene Names

SMYD2, KMT3C

Chain

chain:1-433

Reference Genes

BioGPS Gene:56950 SMYD2

COSMIC (genes):SMYD2 SMYD2

CTD Gene:56950 SMYD2

dbSNP Gene:56950 SMYD2

ENSEMBL:ENSG00000143499 SMYD2

ENSEMBL_homo_sapiens_GENE:ENSG00000143499.14 SMYD2

HGNC:20982 SMYD2

KEGG Gene (Homo sapiens):56950 SMYD2

Monarch:56950 SMYD2

NCBI Gene:56950 SMYD2

OMIM:610663 SMYD2

UCSC:Q9NRG4 SMYD2

Reference Transcript

RefSeq:NM_020197.2 SMYD2

Other Identifiers

11754789_a_at

16677407

212922_PM_s_at

212922_s_at

2379762

2379763

2379764

2379778

2379779

2379780

2379781

2379787

2379791

2379792

2379793

2379794

2379798

2379800

2379804

2379805

2379806

56950

7909689

A_14_P108715

A_14_P126738

A_23_P170587

GE79557

GO:0000122

GO:0000993

GO:0002039

GO:0003824

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006325

GO:0006338

GO:0006351

GO:0006355

GO:0007507

GO:0008168

GO:0008285

GO:0016278

GO:0016279

GO:0016740

GO:0018026

GO:0018027

GO:0023052

GO:0032259

GO:0034968

GO:0036211

GO:0042054

GO:0043226

GO:0043516

GO:0046872

GO:0046975

GO:0048856

GO:0140096

GO:0140938

GO:0140999

GO:1901796

HMNXSV003038187

Hs.66170.1.A1_3p_a_at

PH_hs_0004043

TC01001790.hg

Participates

as a member of

WHSC1, NSD1, SMYD2, ASH1L [nucleoplasm] (Homo sapiens)

Inferred To

set-30 [nucleoplasm] (Caenorhabditis elegans)

SET5 [nucleoplasm] (Saccharomyces cerevisiae)

SET6 [nucleoplasm] (Saccharomyces cerevisiae)

Homologues of SMYD2 [nucleoplasm] (Caenorhabditis elegans)

Homologues of SMYD2 [nucleoplasm] (Dictyostelium discoideum)

Homologues of SMYD2 [nucleoplasm] (Plasmodium falciparum)

Homologues of SMYD2 [nucleoplasm] (Saccharomyces cerevisiae)

Smyd3 [nucleoplasm] (Drosophila melanogaster)

set-10 [nucleoplasm] (Caenorhabditis elegans)

SMYD2 [nucleoplasm] (Bos taurus)

SMYD2 [nucleoplasm] (Caenorhabditis elegans)

SMYD2 [nucleoplasm] (Canis familiaris)

SMYD2 [nucleoplasm] (Danio rerio)

SMYD2 [nucleoplasm] (Dictyostelium discoideum)

SMYD2 [nucleoplasm] (Mus musculus)

SMYD2 [nucleoplasm] (Plasmodium falciparum)

SMYD2 [nucleoplasm] (Rattus norvegicus)

SMYD2 [nucleoplasm] (Schizosaccharomyces pombe)

SMYD2 [nucleoplasm] (Sus scrofa)

bopA [nucleoplasm] (Dictyostelium discoideum)

Cross References

RefSeq

NP_064582.2

ZINC - World Drugs

SMYD2_HUMAN

Guide to Pharmacology - Targets

2714

OpenTargets

ENSG00000143499

ZINC - Substances

SMYD2_HUMAN

ZINC - Biogenic

SMYD2_HUMAN

ZINC target

Q9NRG4

PRO

Q9NRG4

PDB

5KJK, 3S7F, 5ARG, 3S7J, 5KJN, 6CBY, 5ARF, 5V3H, 6N3G, 3RIB, 4YND, 6MON, 6CBX, 5KJM, 4O6F, 5WCG, 3TG4, 4WUY, 3S7B, 5KJL, 3TG5, 3S7D

ZINC - Metabolites

SMYD2_HUMAN

IntEnz

2.1.1.354

HPA

ENSG00000143499-SMYD2

GeneCards

Q9NRG4

Ensembl

ENST00000366957, ENSG00000143499, ENSP00000355924

Pharos - Targets

Q9NRG4

ZINC - Predictions - Purchasable

SMYD2_HUMAN

HMDB Protein

HMDBP11961

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P04637 TP53	20	Unfolded TP53 [cytosol] (R-HSA-6813797) TP53 [cytosol] (R-HSA-8869337) PolyUb-TP53 [nucleoplasm] (R-HSA-6782509) polySUMO2,3-K386-TP53 [nucleoplasm] (R-HSA-2997661) TP53 F341C [nucleoplasm] (R-HSA-9726318) TP53 G334V [nucleoplasm] (R-HSA-9726126) TP53 L330H [nucleoplasm] (R-HSA-9726124) TP53 A347T [nucleoplasm] (R-HSA-9726339) TP53 R337C [nucleoplasm] (R-HSA-9726118) TP53 L344P [nucleoplasm] (R-HSA-9726075) TP53 L344R [nucleoplasm] (R-HSA-9726073) TP53 R337H [nucleoplasm] (R-HSA-9726169) TP53 R337P [nucleoplasm] (R-HSA-9726168) TP53 L330P [nucleoplasm] (R-HSA-9726136) TP53 L348S [nucleoplasm] (R-HSA-9726366) TP53 R337L [nucleoplasm] (R-HSA-9726163) TP53 K351E [nucleoplasm] (R-HSA-9726258) TP53 F338I [nucleoplasm] (R-HSA-9726358) TP53 R342P [nucleoplasm] (R-HSA-9726101) TP53 L330R [nucleoplasm] (R-HSA-9726133)	0.806	6
UniProt:Q15185 PTGES3	2	PTGES3 [nucleoplasm] (R-HSA-5082403) PTGES3 [cytosol] (R-HSA-265269)	0.669	3
UniProt:Q9UPZ9 CILK1			0.657	3
UniProt:Q16543 CDC37	1	CDC37 [cytosol] (R-HSA-1221609)	0.564	2
UniProt:P20290-2 BTF3			0.556	3
UniProt:Q9Y5W9 SNX11			0.556	3
UniProt:Q96K17 BT3L4			0.556	3
UniProt:O60293 ZC3H1			0.527	2
UniProt:Q9BZS1 FOXP3	1	FOXP3 [nucleoplasm] (R-HSA-8865539)	0.527	2
UniProt:Q9UNI1 CELA1			0.527	2
UniProt:Q9H9D4 ZN408			0.527	2
UniProt:P01160 NPPA	5	NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-151) [extracellular region] (R-HSA-976950) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794)	0.527	2

Cite Us!