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VPS35 [cytosol]
Stable Identifier
R-HSA-3247740
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
retromer, MEM3
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
WNT ligand biogenesis and trafficking (Homo sapiens)
Retromer associates with WLS (Homo sapiens)
VPS35:VPS29:VPS26 [cytosol] (Homo sapiens)
VPS35 [cytosol] (Homo sapiens)
WLS:retromer [early endosome membrane] (Homo sapiens)
VPS35:VPS29:VPS26 [cytosol] (Homo sapiens)
VPS35 [cytosol] (Homo sapiens)
Retromer recycles WLS to the Golgi (Homo sapiens)
WLS:retromer [Golgi membrane] (Homo sapiens)
VPS35:VPS29:VPS26 [cytosol] (Homo sapiens)
VPS35 [cytosol] (Homo sapiens)
WLS:retromer [early endosome membrane] (Homo sapiens)
VPS35:VPS29:VPS26 [cytosol] (Homo sapiens)
VPS35 [cytosol] (Homo sapiens)
WLS dissociates from retromer (Homo sapiens)
VPS35:VPS29:VPS26 [cytosol] (Homo sapiens)
VPS35 [cytosol] (Homo sapiens)
WLS:retromer [Golgi membrane] (Homo sapiens)
VPS35:VPS29:VPS26 [cytosol] (Homo sapiens)
VPS35 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q96QK1 VPS35
Gene Names
VPS35, MEM3, TCCCTA00141
Chain
chain:1-796
Reference Genes
BioGPS Gene:55737 VPS35
COSMIC (genes):VPS35 VPS35
CTD Gene:55737 VPS35
dbSNP Gene:55737 VPS35
ENSEMBL:ENSG00000069329 VPS35
ENSEMBL:ENSG00000069329.18 VPS35
HGNC:13487 VPS35
KEGG Gene (Homo sapiens):55737 VPS35
Monarch:55737 VPS35
NCBI Gene:55737 VPS35
OMIM:601501 VPS35
UCSC:Q96QK1 VPS35
Reference Transcript
RefSeq:NM_018206.5 VPS35
Other Identifiers
11743390_s_at
11743391_a_at
11752057_a_at
16826175
17121394
217727_PM_x_at
217727_x_at
222387_PM_s_at
222387_s_at
222388_PM_s_at
222388_s_at
233864_PM_s_at
233864_s_at
3658598
3658603
3658605
3658607
3658625
3658627
3689925
3689926
3689927
3689928
3689929
3689930
3689931
3689936
3689938
3689939
3689941
3689943
3689944
3689946
3689947
3689948
3689949
3689951
3689952
3689954
3689955
3689957
3689960
3689965
55737
55885_at
56344_at
70292_at
8001149
90785_at
90787_g_at
A_21_P0011439
A_24_P270769
A_32_P3556
GE61700
GE62986
GO:0005515
GO:0005576
GO:0005615
GO:0005737
GO:0005739
GO:0005764
GO:0005765
GO:0005768
GO:0005769
GO:0005770
GO:0005773
GO:0005829
GO:0006886
GO:0006914
GO:0006954
GO:0007005
GO:0007040
GO:0010008
GO:0010628
GO:0010629
GO:0010821
GO:0012501
GO:0014069
GO:0015031
GO:0016020
GO:0016055
GO:0016192
GO:0016241
GO:0023052
GO:0030163
GO:0030904
GO:0030906
GO:0031410
GO:0031647
GO:0031648
GO:0031748
GO:0032456
GO:0032463
GO:0033365
GO:0034330
GO:0036010
GO:0042147
GO:0043005
GO:0043025
GO:0043226
GO:0043653
GO:0045056
GO:0045202
GO:0045732
GO:0048471
GO:0048856
GO:0050728
GO:0050804
GO:0050877
GO:0050882
GO:0051246
GO:0060161
GO:0061357
GO:0065003
GO:0070062
GO:0072659
GO:0090128
GO:0090141
GO:0090263
GO:0090326
GO:0097422
GO:0098691
GO:0098793
GO:0098794
GO:0098887
GO:0098978
GO:0099003
GO:0099073
GO:0099074
GO:0099639
GO:0110165
GO:0150052
GO:1901215
GO:1902823
GO:1902950
GO:1903181
GO:1903828
GO:1905166
GO:1905606
GO:2000331
HMNXSV003011299
Hs.264190.0.S1_3p_a_at
ILMN_1761721
PH_hs_0030427
TC16001084.hg
TC16001523.hg
g11875332_3p_a_at
g8922645_3p_a_at
Participates
as a component of
VPS35:VPS29:VPS26 [cytosol] (Homo sapiens)
Inferred To
bZ34G2.3 [cytosol]
(Danio rerio)
vps-35 [cytosol]
(Caenorhabditis elegans)
vps35 [cytosol]
(Dictyostelium discoideum)
vps35 [cytosol]
(Schizosaccharomyces pombe)
vps35 [cytosol]
(Xenopus tropicalis)
Vps35 [cytosol]
(Drosophila melanogaster)
Vps35 [cytosol]
(Mus musculus)
Vps35 [cytosol]
(Rattus norvegicus)
VPS35 [cytosol]
(Bos taurus)
VPS35 [cytosol]
(Canis familiaris)
VPS35 [cytosol]
(Gallus gallus)
VPS35 [cytosol]
(Plasmodium falciparum)
VPS35 [cytosol]
(Saccharomyces cerevisiae)
VPS35 [cytosol]
(Sus scrofa)
Cross References
RefSeq
NP_060676.2
OpenTargets
ENSG00000069329
HPA
ENSG00000069329-VPS35
GeneCards
Q96QK1
Ensembl
ENST00000299138
,
ENSP00000299138
,
ENSG00000069329
PRO
Q96QK1
Pharos - Targets
Q96QK1
Orphanet
20635
PDB
5F0J
,
7BLO
,
5F0K
,
7BLN
,
5F0L
,
5OSI
,
5F0M
,
2R17
,
5OSH
,
5F0P
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.483
7
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