Reactome | VPS35 [cytosol]

VPS35 [cytosol]

Stable Identifier

R-HSA-3247740

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

retromer, MEM3

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q96QK1 VPS35

Gene Names

VPS35, MEM3, TCCCTA00141

Chain

chain:1-796

Reference Genes

BioGPS Gene:55737 VPS35

COSMIC (genes):VPS35 VPS35

CTD Gene:55737 VPS35

dbSNP Gene:55737 VPS35

ENSEMBL:ENSG00000069329 VPS35

HGNC:13487 VPS35

KEGG:hsa:55737 VPS35

Monarch:55737 VPS35

NCBI Gene:55737 VPS35

OMIM:601501 VPS35

UCSC:Q96QK1 VPS35

Reference Transcript

RefSeq:NM_018206.5 VPS35

Other Identifiers

11743390_s_at

11743391_a_at

11752057_a_at

16826175

17121394

217727_PM_x_at

217727_x_at

222387_PM_s_at

222387_s_at

222388_PM_s_at

222388_s_at

233864_PM_s_at

233864_s_at

3658598

3658603

3658605

3658607

3658619

3658625

3658627

3689925

3689926

3689927

3689928

3689929

3689930

3689931

3689932

3689933

3689934

3689935

3689936

3689938

3689939

3689941

3689942

3689943

3689944

3689946

3689947

3689948

3689949

3689950

3689951

3689952

3689953

3689954

3689955

3689956

3689957

3689958

3689959

3689960

3689962

3689963

3689964

3689965

55737

55885_at

56344_at

70292_at

8001149

90785_at

90787_g_at

A_21_P0011439

A_24_P270769

A_32_P3556

GE61700

GE62986

GO:0005515

GO:0005737

GO:0005739

GO:0005764

GO:0005765

GO:0005768

GO:0005769

GO:0005770

GO:0005773

GO:0005829

GO:0006886

GO:0007005

GO:0007040

GO:0010008

GO:0010628

GO:0010629

GO:0010821

GO:0014069

GO:0015031

GO:0016020

GO:0016055

GO:0016192

GO:0016241

GO:0030904

GO:0030906

GO:0031410

GO:0031647

GO:0031648

GO:0031748

GO:0032456

GO:0032463

GO:0033365

GO:0036010

GO:0042147

GO:0043005

GO:0043025

GO:0043226

GO:0043653

GO:0045056

GO:0045202

GO:0045732

GO:0048471

GO:0050728

GO:0050804

GO:0050877

GO:0050882

GO:0051246

GO:0060161

GO:0061357

GO:0070062

GO:0072659

GO:0090128

GO:0090141

GO:0090263

GO:0090326

GO:0097422

GO:0098691

GO:0098793

GO:0098794

GO:0098887

GO:0098978

GO:0099003

GO:0099073

GO:0099074

GO:0099639

GO:0150052

GO:1902823

GO:1902950

GO:1903181

GO:1903828

GO:1904377

GO:1905166

GO:1905606

GO:2000331

HMNXSV003011299

HMNXSV003057454

Hs.264190.0.S1_3p_a_at

ILMN_1761721

PH_hs_0030427

TC16001084.hg

TC16001523.hg

g11875332_3p_a_at

g8922645_3p_a_at

p6000

Participates

as a component of

VPS35:VPS29:VPS26 [cytosol] (Homo sapiens)

Inferred To

vps-35 [cytosol] (Caenorhabditis elegans)

vps35 [cytosol] (Dictyostelium discoideum)

vps35 [cytosol] (Schizosaccharomyces pombe)

vps35 [cytosol] (Xenopus tropicalis)

Vps35 [cytosol] (Drosophila melanogaster)

Vps35 [cytosol] (Mus musculus)

Vps35 [cytosol] (Rattus norvegicus)

VPS35 [cytosol] (Bos taurus)

VPS35 [cytosol] (Canis familiaris)

VPS35 [cytosol] (Gallus gallus)

VPS35 [cytosol] (Plasmodium falciparum)

VPS35 [cytosol] (Saccharomyces cerevisiae)

VPS35 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_060676.2

ENSEMBL

ENSP00000299138, ENST00000299138

OpenTargets

ENSG00000069329

HPA

ENSG00000069329-VPS35

PRO

Q96QK1

Pharos - Targets

Q96QK1

GlyGen

Q96QK1

Orphanet

VPS35

PDB

8R02, 2R17, 5F0L, 5F0P, 5OSI, 8RKS, 5F0J, 7BLN, 5F0K, 7BLO, 8R0J, 5OSH, 5F0M

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P05067 APP	20	APP(672-713) [extracellular region] (R-HSA-879340) APP(672-711) [cytosol] (R-HSA-877188) APP(672-711) [extracellular region] (R-HSA-976740) APP [endoplasmic reticulum lumen] (R-HSA-8956696) p-APP [endoplasmic reticulum lumen] (R-HSA-8957012) APP(18-770) [endosome lumen] (R-HSA-5229077) APP(672-711) [endosome lumen] (R-HSA-6783333) APP(672-713) [endosome lumen] (R-HSA-5692993) APP(672-770) [endosome lumen] (R-HSA-9010082) APP(712-770) [endosome lumen] (R-HSA-6783331) APP(714-770) [endosome lumen] (R-HSA-6783325) APP(18-671) [endosome lumen] (R-HSA-5693003) APP(18-770) [plasma membrane] (R-HSA-9010038) APP(18-770) [Golgi lumen] (R-HSA-8871509) APP(688-770) [plasma membrane] (R-HSA-9010028) APP(18-687) [extracellular region] (R-HSA-9010033) APP(18-770) [platelet alpha granule lumen] (R-HSA-139835) APP(18-770) [extracellular region] (R-HSA-49335) APP-C99 [cytosol] (R-HSA-9617603) APP(18-770) [trans-Golgi network membrane] (R-HSA-5229136)	0.556	3
UniProt:O60493 SNX3	3	SNX3 [cytosol] (R-HSA-3247743) PolyUb-SNX3 [endosome membrane] (R-HSA-6782993) SNX3 [endosome membrane] (R-HSA-6782991)	0.527	3
UniProt:P33993 MCM7	1	MCM7 [nucleoplasm] (R-HSA-68555)	0.527	3
UniProt:Q6IN84 MRM1	1	MRM1 [mitochondrial matrix] (R-HSA-6793088)	0.527	4
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	7
UniProt:Q7Z3C6 ATG9A	1	ATG9A [phagophore assembly site membrane] (R-HSA-5671732)	0.463	2

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