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CCS [cytosol]
Stable Identifier
R-HSA-3299714
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Copper chaperone for superoxide dismutase, CCS_HUMAN
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
2xSOD1:CCS:Zn2+:2xCu1+ dimer dissociates (Homo sapiens)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Homo sapiens)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Homo sapiens)
CCS:Zn2+:2xCu1+ [cytosol] (Homo sapiens)
CCS [cytosol] (Homo sapiens)
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Homo sapiens)
CCS:Zn2+:2xCu1+ [cytosol] (Homo sapiens)
CCS [cytosol] (Homo sapiens)
CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Homo sapiens)
CCS [cytosol] (Homo sapiens)
CCS:Zn2+:2xCu1+:SOD1:Zn2+ [cytosol] (Homo sapiens)
CCS:Zn2+:2xCu1+ [cytosol] (Homo sapiens)
CCS [cytosol] (Homo sapiens)
CCS:Zn2+:Cu1+ dimer [cytosol] (Homo sapiens)
CCS:Zn2+:Cu1+ [cytosol] (Homo sapiens)
CCS [cytosol] (Homo sapiens)
SOD1:Zn2+ apoenzyme binds CCS:Zn2+:2xCu1+ (Homo sapiens)
2xSOD1:CCS:Zn2+:2xCu1+ dimer [cytosol] (Homo sapiens)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Homo sapiens)
CCS:Zn2+:2xCu1+ [cytosol] (Homo sapiens)
CCS [cytosol] (Homo sapiens)
CCS:Zn2+:2xCu1+ dimer [cytosol] (Homo sapiens)
CCS:Zn2+:2xCu1+ [cytosol] (Homo sapiens)
CCS [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:O14618 CCS
Gene Names
CCS
Chain
chain:1-274
Reference Genes
BioGPS Gene:9973 CCS
COSMIC (genes):CCS CCS
CTD Gene:9973 CCS
dbSNP Gene:9973 CCS
ENSEMBL:ENSG00000173992 CCS
HGNC:1613 CCS
KEGG:hsa:9973 CCS
Monarch:9973 CCS
NCBI Gene:9973 CCS
OMIM:603864 CCS
UCSC:O14618 CCS
Reference Transcript
RefSeq:NM_005125.1 CCS
Other Identifiers
11720675_a_at
11720676_s_at
16727524
203522_PM_at
203522_at
3336352
3336353
3336354
3336355
3336356
3336357
3336358
3336359
3336360
3336361
3336362
3336363
3336364
3336365
3336366
3336367
36068_at
58948_at
7941685
9973
A_14_P114545
A_14_P200312
A_23_P127475
GE54047
GO:0003824
GO:0005507
GO:0005515
GO:0005634
GO:0005737
GO:0005739
GO:0005829
GO:0006801
GO:0015035
GO:0015680
GO:0016491
GO:0016532
GO:0019430
GO:0034599
GO:0043226
GO:0045296
GO:0046872
GO:0051604
GO:0098754
GO:0140096
GO:0140104
HMNXSV003029983
ILMN_1748407
ILMN_1766797
ILMN_2290998
PH_hs_0000512
TC11000672.hg
g4826664_3p_at
Participates
as a component of
CCS:Zn2+:Cu1+ [cytosol] (Homo sapiens)
CCS:Zn2+:2xCu1+ [cytosol] (Homo sapiens)
Other forms of this molecule
CCS [mitochondrial intermembrane space]
Inferred To
CCS [cytosol]
(Bos taurus)
CCS [cytosol]
(Canis familiaris)
CCS [cytosol]
(Dictyostelium discoideum)
CCS [cytosol]
(Gallus gallus)
CCS [cytosol]
(Mus musculus)
CCS [cytosol]
(Rattus norvegicus)
CCS [cytosol]
(Saccharomyces cerevisiae)
CCS [cytosol]
(Sus scrofa)
Ccs [cytosol]
(Drosophila melanogaster)
ccs [cytosol]
(Xenopus tropicalis)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 141 and 227
Coordinate
141
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
ENSEMBL
ENST00000533244
,
ENSP00000436318
OpenTargets
ENSG00000173992
HPA
ENSG00000173992-CCS
PRO
O14618
Pharos - Targets
O14618
GlyGen
O14618
HMDB Protein
HMDBP08238
PDB
2RSQ
,
6FON
,
6FN8
,
6FOL
,
6FP6
,
1DO5
,
2CRL
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00441 SOD1
5
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [extracellular region]
(R-HSA-350705)
0.832
7
UniProt:P98170 XIAP
3
XIAP [cytosol]
(R-HSA-50849)
K48pUb-XIAP [cytosol]
(R-HSA-5675477)
XIAP [nucleoplasm]
(R-HSA-3322366)
0.499
2
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