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2xHC-SOD1 [cytosol]
Stable Identifier
R-HSA-3299726
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
SOD1 (disulfide bonded), Superoxide dismutase [Cu-Zn] ecNumber1.15.1.1/ecNumber, SODC_HUMAN
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular response to chemical stress (Homo sapiens)
Detoxification of Reactive Oxygen Species (Homo sapiens)
CCS transfers Cu to SOD1 and oxidizes cysteine residues in SOD1 (Homo sapiens)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Homo sapiens)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Homo sapiens)
2xHC-SOD1 [cytosol] (Homo sapiens)
SOD1 catalyzes 2H+ + 2O2.- => O2 + H2O2 (cytosol) (Homo sapiens)
2xHC-SOD1:Zn2+:Cu2+ dimer [cytosol] (Homo sapiens)
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Homo sapiens)
2xHC-SOD1 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:P00441 SOD1
Gene Names
SOD1
Chain
initiator methionine:, chain:2-154
Reference Genes
BioGPS Gene:6647 SOD1
COSMIC (genes):SOD1 SOD1
CTD Gene:6647 SOD1
dbSNP Gene:6647 SOD1
ENSEMBL:ENSG00000142168 SOD1
HGNC:11179 SOD1
KEGG:hsa:6647 SOD1
Monarch:6647 SOD1
NCBI Gene:6647 SOD1
OMIM:147450 SOD1
UCSC:P00441 SOD1
Reference Transcript
RefSeq:NM_000454.4 SOD1
Other Identifiers
11716935_a_at
11756351_x_at
11757619_x_at
16922102
200642_PM_at
200642_at
36620_at
3917873
3917874
3917875
3917876
3917878
3917882
3917888
3917890
3917891
3917892
3917893
3917894
3917895
3917896
3917897
3917911
6647
8068168
A_14_P105406
A_23_P154840
A_24_P151464
GE79683
GO:0000302
GO:0000303
GO:0001541
GO:0001819
GO:0001890
GO:0001895
GO:0002262
GO:0002376
GO:0003012
GO:0003013
GO:0003824
GO:0004784
GO:0005507
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005737
GO:0005739
GO:0005758
GO:0005759
GO:0005777
GO:0005829
GO:0005886
GO:0006575
GO:0006749
GO:0006790
GO:0006801
GO:0006879
GO:0006915
GO:0006979
GO:0007010
GO:0007018
GO:0007283
GO:0007566
GO:0007605
GO:0007626
GO:0008089
GO:0008090
GO:0008217
GO:0008270
GO:0008340
GO:0009408
GO:0009410
GO:0010467
GO:0012501
GO:0016209
GO:0016491
GO:0019226
GO:0019228
GO:0019430
GO:0022414
GO:0030346
GO:0031267
GO:0031410
GO:0032287
GO:0032839
GO:0032930
GO:0032991
GO:0033081
GO:0035234
GO:0040014
GO:0042542
GO:0042554
GO:0042802
GO:0042803
GO:0043025
GO:0043065
GO:0043066
GO:0043087
GO:0043226
GO:0043410
GO:0043524
GO:0045471
GO:0046620
GO:0046716
GO:0046872
GO:0048538
GO:0048678
GO:0048856
GO:0050665
GO:0050728
GO:0050766
GO:0050877
GO:0051087
GO:0051093
GO:0051881
GO:0060047
GO:0060052
GO:0060087
GO:0060088
GO:0061024
GO:0070062
GO:0072593
GO:0098754
GO:0099610
GO:1902177
GO:1904115
GO:2000242
HMNXSV003042786
ILMN_1662438
PH_hs_0025933
TC21000111.hg
X02317_at
g4507148_3p_at
Participates
as a component of
2xHC-SOD1:Zn2+:Cu2+ [cytosol] (Homo sapiens)
Other forms of this molecule
SOD1 [cytosol]
2xHC-SOD1 [mitochondrial intermembrane space]
SOD1 [mitochondrial intermembrane space]
SOD1 [extracellular region]
Inferred To
2xHC-SOD1 [cytosol]
(Bos taurus)
2xHC-SOD1 [cytosol]
(Caenorhabditis elegans)
2xHC-SOD1 [cytosol]
(Danio rerio)
2xHC-SOD1 [cytosol]
(Dictyostelium discoideum)
2xHC-SOD1 [cytosol]
(Drosophila melanogaster)
2xHC-SOD1 [cytosol]
(Gallus gallus)
2xHC-SOD1 [cytosol]
(Mus musculus)
2xHC-SOD1 [cytosol]
(Rattus norvegicus)
2xHC-SOD1 [cytosol]
(Saccharomyces cerevisiae)
2xHC-SOD1 [cytosol]
(Schizosaccharomyces pombe)
2xHC-SOD1 [cytosol]
(Sus scrofa)
2xHC-SOD1 [cytosol]
(Xenopus tropicalis)
SOD1 [cytosol]
(Canis familiaris)
Homologues of 2xHC-SOD1 [cytosol]
(Bos taurus)
Modified Residues
Name
Intra-chain Crosslink via L-cystine (cross-link) at 57 and 146
Coordinate
57
PsiMod Name
L-cystine (cross-link)
PsiMod Definition
A protein modification that effectively cross-links two L-cysteine residues to form L-cystine.
Cross References
OpenTargets
ENSG00000142168
ENSEMBL
ENST00000270142
,
ENSP00000270142
HPA
ENSG00000142168-SOD1
ZINC - Substances
SODC_HUMAN
ZINC target
P00441
PRO
P00441
Pharos - Targets
P00441
GlyGen
P00441
Orphanet
SOD1
HMDB Protein
HMDBP02053
PDB
6SPH
,
4BCZ
,
2GBT
,
2VR8
,
2WZ5
,
6Z4H
,
7FB9
,
2VR7
,
6SPA
,
3K91
,
1HL5
,
1AZV
,
4A7U
,
2WZ6
,
3QQD
,
2R27
,
5O40
,
6FOL
,
2ZKY
,
5WMJ
,
7T8G
,
4OH2
,
1OZU
,
2AF2
,
3T5W
,
4MCM
,
7CJW
,
2GBU
,
5WOR
,
5IIW
,
2XJL
,
1L3N
,
5J07
,
5YTU
,
2MP3
,
6FFK
,
6Z4I
,
2WYT
,
3CQP
,
5J0C
,
8GSQ
,
7FB6
,
4A7T
,
3KH4
,
1OEZ
,
4BCY
,
8Q6M
,
6FOI
,
4NIN
,
3CQQ
,
2VR6
,
3GZO
,
4FF9
,
1P1V
,
2ZKX
,
8CCX
,
1DSW
,
1UXL
,
2WZ0
,
1MFM
,
6Z4O
,
5U9M
,
6Z3V
,
1N18
,
6Z4M
,
2LU5
,
2C9S
,
3H2Q
,
6A9O
,
5J0G
,
7XX3
,
5DLI
,
6SPI
,
6Z4J
,
6B79
,
3LTV
,
3GQF
,
3RE0
,
3ECU
,
3GZQ
,
1SOS
,
6DTK
,
1OZT
,
2ZKW
,
5YTO
,
5O3Y
,
1PTZ
,
1UXM
,
7CJV
,
7T8F
,
2C9V
,
3HFF
,
3ECW
,
1KMG
,
1N19
,
6Z4G
,
2C9U
,
4BD4
,
4A7Q
,
3KH3
,
4NIO
,
5J0F
,
7VZF
,
3H2P
,
2WKO
,
6SPJ
,
6Z4K
,
6FON
,
4A7V
,
6FP6
,
4B3E
,
3ECV
,
2NAM
,
4NIP
,
6SPK
,
4A7S
,
3GZP
,
1HL4
,
1BA9
,
1SPD
,
4XCR
,
7NXX
,
5K02
,
2XJK
,
1PU0
,
7T8H
,
3GTV
,
4A7G
,
4MCN
,
7T8E
,
2WYZ
,
2V0A
,
2GBV
,
1FUN
,
6FLH
,
2NNX
,
6Z4L
,
1RK7
,
5YUL
Interactors (93)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00441 SOD1
5
2xHC-SOD1 [cytosol]
(R-HSA-3299726)
SOD1 [cytosol]
(R-HSA-350697)
2xHC-SOD1 [mitochondrial intermembrane space]
(R-HSA-3777108)
SOD1 [mitochondrial intermembrane space]
(R-HSA-3777082)
SOD1 [extracellular region]
(R-HSA-350705)
0.978
22
UniProt:O14618 CCS
2
CCS [mitochondrial intermembrane space]
(R-HSA-3777060)
CCS [cytosol]
(R-HSA-3299714)
0.832
7
UniProt:P20029 Hspa5
7
78 kDa glucose-regulated protein precursor [extracellular region]
(R-MMU-351324)
78 kDa glucose-regulated protein precursor [endoplasmic reticulum lumen]
(R-MMU-351326)
HSPA5 [endoplasmic reticulum lumen]
(R-MMU-387190)
HSPA5 [endoplasmic reticulum membrane]
(R-MMU-351315)
HSPA5 [cytosol]
(R-MMU-5252115)
HSPA5 [nucleoplasm]
(R-MMU-5252042)
HSPA5 [lumenal side of endoplasmic reticulum membrane]
(R-MMU-985498)
0.688
7
UniProt:P62191 PSMC1
2
PSMC1 [cytosol]
(R-HSA-68768)
PSMC1 [nucleoplasm]
(R-HSA-174338)
0.666
5
UniProt:P26339
2
Chga [extracellular region]
(R-MMU-6808568)
Chga [extracellular region]
(R-MMU-6808524)
0.625
5
UniProt:P30044 PRDX6
0.612
10
UniProt:P16014
2
phospho-Chgb [endoplasmic reticulum lumen]
(R-MMU-8956928)
Chgb [endoplasmic reticulum lumen]
(R-MMU-8956734)
0.602
6
UniProt:Q9BXK5 B2L13
0.589
2
UniProt:P37840 SNCA
5
SNCA [cytosol]
(R-HSA-5658500)
p-S129-SNCA [cytosol]
(R-HSA-9836432)
Ub-SNCA [cytosol]
(R-HSA-5660754)
SNCA [extracellular region]
(R-HSA-976954)
SNCA A30P [cytosol]
(R-HSA-5658569)
0.567
9
UniProt:P29692 EEF1D
1
EEF1D [cytosol]
(R-HSA-156914)
0.564
3
IntAct:EBI-25835814 CCSB
0.556
3
UniProt:Q96MF2 STAC3
0.556
3
UniProt:Q8WW76 Q8WW76
0.556
3
UniProt:Q3SY56 SP6
0.556
3
UniProt:P07951-2 TPM2
0.556
3
UniProt:Q9H3N1 TMX1
0.556
3
IntAct:EBI-25850770 CCSB
0.556
3
UniProt:A4FUJ8 A4FUJ8
0.556
3
UniProt:Q08209-2 PPP3CA
0.556
3
UniProt:Q0P5N6 ARL16
0.556
3
UniProt:P48730-2 CSNK1D
0.556
3
UniProt:P17980 PSMC3
5
PSMC3 [cytosol]
(R-HSA-68774)
PSMC3 [nucleoplasm]
(R-HSA-174313)
PSMC3 [secretory granule lumen]
(R-HSA-6800917)
PSMC3 [extracellular region]
(R-HSA-6806496)
PSMC3 [ficolin-1-rich granule lumen]
(R-HSA-6800429)
0.556
3
UniProt:Q15554-4 Q155544
0.556
3
UniProt:Q13191 CBLB
1
CBLB [cytosol]
(R-HSA-976009)
0.556
3
UniProt:P10415 BCL2
1
BCL2 [mitochondrial outer membrane]
(R-HSA-50757)
0.556
3
UniProt:Q9GZS3 SKIC8
2
WDR61 [cytosol]
(R-HSA-8931534)
WDR61 [nucleoplasm]
(R-HSA-8866696)
0.556
3
UniProt:Q2NKQ1-4 SGSM1
0.556
3
IntAct:EBI-25934407 CCSB
0.556
3
UniProt:O95777 LSM8
1
LSM8 [nucleoplasm]
(R-HSA-6806779)
0.556
3
UniProt:P28062-2 PSMB8
0.556
3
UniProt:Q9NV58 RNF19A
1
RNF19A [cytosol]
(R-HSA-8850909)
0.556
3
UniProt:Q8NBB4-2 ZSCAN1
0.556
3
UniProt:Q13829 TNFAIP1
1
TNFAIP1 [cytosol]
(R-HSA-9696531)
0.556
3
UniProt:P13928 ANXA8
0.556
3
UniProt:P08865 RPSA
2
RPSA [cytosol]
(R-HSA-72389)
RPSA [nucleoplasm]
(R-HSA-6798722)
0.556
3
UniProt:P53672 CRBA2
0.556
3
UniProt:Q5SZD1 CF141
0.556
3
UniProt:Q15046 KARS1
4
KARS [mitochondrial matrix]
(R-HSA-379617)
p-S207 KARS [nucleoplasm]
(R-HSA-9825687)
p-S207 KARS [cytosol]
(R-HSA-9825686)
KARS [cytosol]
(R-HSA-379568)
0.556
3
UniProt:Q96JM7-2 L3MBTL3
0.556
3
UniProt:Q8NHS9 SPT22
0.556
3
UniProt:Q8N594 MPND
0.556
3
UniProt:P43686-2 P436862
0.556
3
UniProt:Q8TC29 ENKUR
0.556
3
UniProt:Q9BYU1 PBX4
0.556
3
UniProt:Q6ZNA4-2 Q6ZNA42
0.556
3
UniProt:P80217-2 IFI35
0.556
3
UniProt:Q8WVV9-3 Q8WVV93
0.556
3
UniProt:P63010-2 AP2B1
0.556
3
IntAct:EBI-25831191 CCSB
0.556
3
UniProt:Q96FW1 OTUB1
2
OTUB1 [nucleoplasm]
(R-HSA-6783242)
OTUB1 [cytosol]
(R-HSA-933411)
0.556
3
UniProt:Q13113 PDZ1I
0.556
3
UniProt:Q9BUL9 RPP25
1
RPP25 [nucleoplasm]
(R-HSA-5696782)
0.556
3
UniProt:O14713 ITBP1
0.556
3
IntAct:EBI-25849442 CCSB
0.556
3
UniProt:Q8N4N3-2 KLHL36
0.556
3
UniProt:Q6GQQ9-2 Q6GQQ92
0.556
3
UniProt:Q15393 SF3B3
1
SF3B3 [nucleoplasm]
(R-HSA-71973)
0.556
3
UniProt:P02748 C9
1
C9(22-559) [extracellular region]
(R-HSA-173717)
0.556
3
UniProt:Q16611 BAK1
2
BAK1 [mitochondrial outer membrane]
(R-HSA-139896)
BAK1 activated [mitochondrial outer membrane]
(R-HSA-50690)
0.556
3
UniProt:Q9BYZ2 LDHAL6B
1
LDHAL6B [mitochondrial matrix]
(R-HSA-6807613)
0.556
3
UniProt:P0CG47 UBB
20
UBB(77-152) [endocytic vesicle membrane]
(R-HSA-939253)
UBB(1-76) [endocytic vesicle membrane]
(R-HSA-939231)
UBB(153-228) [endocytic vesicle membrane]
(R-HSA-939171)
Ub-33-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783023)
Ub-109-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783008)
Ub-185-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783046)
Ub-215-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783002)
Ub-63-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783148)
Ub-139-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783012)
Ub-158-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783162)
Ub-6-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783014)
Ub-82-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783015)
Ub-163-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783025)
Ub-87-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6782998)
Ub-11-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783109)
Ub-124-UBB(77-152) [mitochondrial outer membrane]
(R-HSA-6783131)
Ub-200-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783100)
Ub-48-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783165)
Ub-181-UBB(153-228) [mitochondrial outer membrane]
(R-HSA-6783160)
Ub-29-UBB(1-76) [mitochondrial outer membrane]
(R-HSA-6783070)
0.556
3
UniProt:Q9BZK7 TBL1XR1
1
TBL1XR1 [nucleoplasm]
(R-HSA-351643)
0.556
3
UniProt:Q09028 RBBP4
1
RBBP4 [nucleoplasm]
(R-HSA-212223)
0.556
3
UniProt:P09017 HOXC4
1
HOXC4 [nucleoplasm]
(R-HSA-5617871)
0.556
3
UniProt:P98082 DAB2
3
DAB2 [cytosol]
(R-HSA-8862456)
DAB2 [lysosomal membrane]
(R-HSA-2980807)
DAB2 [plasma membrane]
(R-HSA-2980808)
0.556
3
UniProt:Q96NC0 ZMAT2
1
ZMAT2 [nucleoplasm]
(R-HSA-9770248)
0.556
3
UniProt:P07437 TUBB
3
TUBB [extracellular region]
(R-HSA-380317)
TUBB [azurophil granule lumen]
(R-HSA-6799370)
TUBB [cytosol]
(R-HSA-9020816)
0.556
3
UniProt:P60896 SEM1
2
SEM1 [cytosol]
(R-HSA-8866674)
SEM1 [nucleoplasm]
(R-HSA-8866665)
0.556
3
UniProt:Q8N448 LNX2
0.556
3
UniProt:P02671-2 FGA
0.556
3
IntAct:EBI-25888984 CCSB
0.556
3
UniProt:Q2QGD7 ZXDC
0.556
3
UniProt:P62879 GNB2
4
GNB2 [cytosol]
(R-HSA-6814421)
Partially folded GNB2 [cytosol]
(R-HSA-8850536)
Unfolded GNB2 [cytosol]
(R-HSA-6814202)
GNB2 [plasma membrane]
(R-HSA-164335)
0.556
3
UniProt:Q9NVX7-2 Q9NVX72
0.556
3
UniProt:Q8N488 RYBP
1
RYBP [nucleoplasm]
(R-HSA-8937975)
0.556
3
UniProt:O75604-3 USP2
0.556
3
UniProt:Q92797-2 Q927972
0.556
3
IntAct:EBI-25836274 CCSB
0.556
3
UniProt:Q9Y4H4 GPSM3
1
GPSM3 [cytosol]
(R-HSA-8949486)
0.556
3
UniProt:Q8N5S9-2 Q8N5S92
0.556
3
UniProt:O95789-4 ZMYM6
0.556
3
IntAct:EBI-25934389 CCSB
0.556
3
UniProt:F2Z2M7 F2Z2M7
0.556
3
UniProt:Q9ULX5 RN112
0.556
3
UniProt:Q6DN90-2 Q6DN902
0.556
3
UniProt:Q8TDB4 HUMMR
0.556
3
UniProt:P07686 HEXB
11
HEXB S62L [lysosomal lumen]
(R-HSA-3700901)
HEXB R284* [lysosomal lumen]
(R-HSA-3700930)
HEXB M26Cfs*5 [lysosomal lumen]
(R-HSA-3700843)
HEXB I322Kfs*5 [lysosomal lumen]
(R-HSA-3700889)
HEXB(316-556) [lysosomal lumen]
(R-HSA-1605605)
HEXB(122-311) [azurophil granule lumen]
(R-HSA-6799125)
HEXB(315-556) [azurophil granule lumen]
(R-HSA-6799134)
HEXB(122-311) [extracellular region]
(R-HSA-6806190)
HEXB(315-556) [extracellular region]
(R-HSA-6806188)
HEXB(50-107) [lysosomal lumen]
(R-HSA-9842398)
HEXB(122-311) [lysosomal lumen]
(R-HSA-1605777)
0.527
2
UniProt:Q7Z434 MAVS
2
MAVS [mitochondrial outer membrane]
(R-HSA-913730)
K48polyUb-MAVS [mitochondrial outer membrane]
(R-HSA-983463)
0.527
2
UniProt:Q99497 PARK7
7
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
PARK7 [nucleoplasm]
(R-HSA-3900141)
monoSUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
0.527
2
UniProt:Q9BQE5 APOL2
0.527
2
UniProt:Q8TCX1 DYNC2LI1
2
DYNC2LI1 [ciliary tip]
(R-HSA-5625333)
DYNC2LI1 [cilium]
(R-HSA-5624862)
0.499
3
UniProt:P04406 GAPDH
1
GAPDH [cytosol]
(R-HSA-70428)
0.499
3
UniProt:Q6DN90 IQEC1
0.471
2
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