Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Contributors
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
Ub-121-HIST1H2BJ [nucleoplasm]
Stable Identifier
R-HSA-3364017
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Histone H2B.r K121ub
Locations in the PathwayBrowser
Expand all
Signal Transduction (Homo sapiens)
Signaling by WNT (Homo sapiens)
TCF dependent signaling in response to WNT (Homo sapiens)
Formation of the beta-catenin:TCF transactivating complex (Homo sapiens)
SET1 complex trimethylates H3K4 at the MYC gene (Homo sapiens)
MYC gene: H2B K121ub nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H2BK121ub [nucleoplasm] (Homo sapiens)
Histone H2B K121ub [nucleoplasm] (Homo sapiens)
Ub-121-HIST1H2BJ [nucleoplasm] (Homo sapiens)
MYC gene:H2B K121ub H3K4me3 nucleosome [nucleoplasm] (Homo sapiens)
Nucleosome with H2BK121ub and H3K4me3 [nucleoplasm] (Homo sapiens)
Histone H2B K121ub [nucleoplasm] (Homo sapiens)
Ub-121-HIST1H2BJ [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P06899 H2BC11
Gene Names
H2BC11, H2BFR, HIST1H2BJ
Chain
initiator methionine:, chain:2-126
Reference Genes
BioGPS Gene:8970 H2BC11
CTD Gene:8970 H2BC11
dbSNP Gene:8970 H2BC11
ENSEMBL:ENSG00000124635 HIST1H2BJ
ENSEMBL_homo_sapiens_GENE:ENSG00000124635.9 H2BC11
HGNC:4761 H2BC11
KEGG Gene (Homo sapiens):8970 H2BC11
Monarch:8970 H2BC11
NCBI Gene:8970 H2BC11
OMIM:615044 H2BC11
UCSC:P06899 H2BC11
Reference Transcript
RefSeq:NM_021058.3 H2BC11
Other Identifiers
11741699_at
11741700_s_at
11741701_x_at
153_f_at
17016451
2946699
2946700
2946709
2946710
2946711
2946712
8124484
85177_at
8970
A_24_P359231
A_24_P55148
GE85150
GO:0000786
GO:0001530
GO:0002227
GO:0002376
GO:0003677
GO:0005198
GO:0005515
GO:0005576
GO:0005615
GO:0005634
GO:0005654
GO:0005694
GO:0005829
GO:0005886
GO:0006325
GO:0006334
GO:0008289
GO:0010804
GO:0019731
GO:0023052
GO:0030527
GO:0031640
GO:0042742
GO:0043226
GO:0043229
GO:0043505
GO:0046982
GO:0050829
GO:0050830
GO:0061644
GO:0061844
GO:0065003
GO:0098542
HMNXSV003001392
ILMN_1658702
PH_hs_0035577
TC06001385.hg
TC06001386.hg
X00088_at
Participates
as a candidate of
Histone H2B K121ub [nucleoplasm] (Homo sapiens)
Other forms of this molecule
Ub-HIST1H2BJ [nucleoplasm]
AcK-HIST1H2BJ [nucleoplasm]
HIST1H2BJ [extracellular region]
AcK21-HIST1H2BJ [nucleoplasm]
AcK6-HIST1H2BJ [nucleoplasm]
AcK16-HIST1H2BJ [nucleoplasm]
AcK13-HIST1H2BJ [nucleoplasm]
HIST1H2BJ [nucleoplasm]
Inferred To
H2Bv1 [nucleoplasm]
(Dictyostelium discoideum)
H2B-VIII [nucleoplasm]
(Gallus gallus)
His2B [nucleoplasm]
(Drosophila melanogaster)
H2BC11 [nucleoplasm]
(Bos taurus)
H2Bv2 [nucleoplasm]
(Dictyostelium discoideum)
htb1 [nucleoplasm]
(Schizosaccharomyces pombe)
Ub-121-HIST1H2BK [nucleoplasm]
(Danio rerio)
Ub-121-HIST1H2BK [nucleoplasm]
(Plasmodium falciparum)
h2bc11 [nucleoplasm]
(Xenopus tropicalis)
si:ch211-113a14.29 [nucleoplasm]
(Danio rerio)
HIST1H2B5L [nucleoplasm]
(Gallus gallus)
H2B-V [nucleoplasm]
(Gallus gallus)
LOC100498553 [nucleoplasm]
(Xenopus tropicalis)
LOC116411635 [nucleoplasm]
(Xenopus tropicalis)
H2Bv3 [nucleoplasm]
(Dictyostelium discoideum)
H2B-VII [nucleoplasm]
(Gallus gallus)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Danio rerio)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Dictyostelium discoideum)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Gallus gallus)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Plasmodium falciparum)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Saccharomyces cerevisiae)
Homologues of Ub-121-HIST1H2BK [nucleoplasm]
(Xenopus tropicalis)
H2B-I [nucleoplasm]
(Gallus gallus)
hist2h2l [nucleoplasm]
(Danio rerio)
HTB1 [nucleoplasm]
(Saccharomyces cerevisiae)
LOC570661 [nucleoplasm]
(Danio rerio)
HTB2 [nucleoplasm]
(Saccharomyces cerevisiae)
h2bc21 [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
ubiquitinylated lysine at 121
Coordinate
121
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_066402.2
OpenTargets
ENSG00000124635
GeneCards
P06899
HPA
ENSG00000124635-H2BC11
Ensembl
ENSP00000342886
,
ENSG00000124635
,
ENST00000339812
,
ENST00000607124
,
ENSP00000476136
PRO
P06899
Pharos - Targets
P06899
PDB
6USJ
,
7XTD
,
3W96
,
5B2J
,
7VCL
,
7CCQ
,
7WBX
,
8HAH
,
7XZY
,
6L49
,
3AZM
,
7C0M
,
7Y7I
,
7K5X
,
6E0P
,
7COW
,
5FUG
,
3AZN
,
6J4X
,
5B40
,
5CPI
,
7Y00
,
6E0C
,
8GUK
,
6BUZ
,
6R92
,
8G57
,
7K63
,
8HAL
,
3A6N
,
7NL0
,
6M44
,
3AZI
,
6R91
,
5Y0D
,
6O1D
,
5XF3
,
6R8Y
,
6K1J
,
5AVB
,
7D1Z
,
6KVD
,
3W99
,
5Y0C
,
7ZI4
,
5B33
,
3AZJ
,
3AN2
,
8JLD
,
8HAG
,
6LER
,
5B32
,
4Z5T
,
4YM5
,
6L9Z
,
7WBW
,
7XX5
,
5B2I
,
7CCR
,
6J50
,
6JXD
,
7XX6
,
8HAJ
,
6A5R
,
5JRG
,
7XX7
,
7YRD
,
5ZBX
,
3AZK
,
6IR9
,
7XVM
,
5GXQ
,
6A5O
,
8GUJ
,
8HAK
,
7W9V
,
5X7X
,
3AZL
,
6JR1
,
6LA9
,
6JOU
,
8JLA
,
3AFA
,
3W98
,
5AV9
,
8OSJ
,
3WA9
,
6K1I
,
7WBV
,
8OSK
,
5CPJ
,
8OSL
,
6HKT
,
8H0W
,
5CPK
,
6J51
,
6L4A
,
6T93
,
3WTP
,
6IPU
,
3W97
,
5B31
,
7XSE
,
6J4Z
,
6J4Y
,
6IQ4
,
8HE5
,
3AZH
,
7XZZ
,
8HAI
,
6T90
,
5B0Y
,
2RVQ
,
6R94
,
6A5P
,
5B0Z
,
7XSX
,
5GSE
,
6LAB
,
6R93
,
8HAN
,
5XF4
,
5XF5
,
8JL9
,
6M3V
,
6LA8
,
6R8Z
,
7VZ4
,
6R90
,
5AV8
,
5Z23
,
4CAY
,
5B24
,
5AV6
,
7LYB
,
3AZG
,
7SCY
,
7XZX
,
3AV1
,
7LYC
,
3AV2
,
8H0V
,
6A5T
,
5VEY
,
7XTI
,
6A5U
,
7SCZ
,
7E8D
,
7K60
,
5AY8
,
5Z30
,
6J4W
,
6INQ
,
7K5Y
,
7XVL
,
5AV5
,
8GUI
,
7K61
,
3AZF
,
6YOV
,
3AZE
,
5AVC
,
8HAM
,
6KXV
,
6HTS
,
8I17
,
6A5L
,
7XT7
,
7XSZ
,
3WAA
,
4YM6
,
6JR0
,
3AYW
,
6K1K
,
6LA2
,
7LYA
,
5GTC
,
8OTS
,
8OTT
,
6V2K
,
7D20
,
8JLB
,
7BY0
Interactors (1)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P10636-8 MAPT
3
p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol]
(R-HSA-9836400)
p-S262,S356,S396-MAPT-8 [cytosol]
(R-HSA-9619521)
MAPT-8 [cytosol]
(R-HSA-9619519)
0.527
2
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text