Reactome | Apoptotic cleavage of cell adhesion proteins

Apoptotic cleavage of cell adhesion proteins

Stable Identifier

R-HSA-351906

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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Apoptotic cleavage of cell adhesion proteins

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Apoptotic cells show dramatic rearrangements of tight junctions, adherens junctions, and desmosomes (Abreu et al., 2000). Desmosome-specific members of the cadherin superfamily of cell adhesion molecules including desmoglein-3, plakophilin-1 and desmoplakin are cleaved by caspases after onset of apoptosis (Weiske et al., 2001). Cleavage results in the disruption of the desmosome structure and thus contributes to cell rounding and disintegration of the intermediate filament system (Weiske et al., 2001).

Literature References

PubMed ID	Title	Journal	Year
11500511	The fate of desmosomal proteins in apoptotic cells Weiske, J, Schoneberg, T, Schroder, W, Hatzfeld, M, Tauber, R, Huber, O	J Biol Chem	2001
17559062	The most widespread desmosomal cadherin, desmoglein 2, is a novel target of caspase 3-mediated apoptotic machinery Cirillo, N, Lanza, M, De Rosa, A, Cammarota, M, La Gatta, A, Gombos, F, Lanza, A	J Cell Biochem	2008
16286477	The differentiation-dependent desmosomal cadherin desmoglein 1 is a novel caspase-3 target that regulates apoptosis in keratinocytes Dusek, RL, Getsios, S, Chen, F, Park, JK, Amargo, EV, Cryns, VL, Green, KJ	J Biol Chem	2006