Reactome | GRB2:SOS provides linkage to MAPK signaling for Integrins

GRB2:SOS provides linkage to MAPK signaling for Integrins

Stable Identifier

R-HSA-354194

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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GRB2:SOS provides linkage to MAPK signaling for Integrins

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Integrin signaling is linked to the MAP kinase pathway by recruiting Grb2 to the FADK1/SRC activation complex.

Literature References

PubMed ID	Title	Journal	Year
7997267	Integrin-mediated signal transduction linked to Ras pathway by GRB2 binding to focal adhesion kinase Schlaepfer, DD, Hanks, SK, Hunter, T, van der Geer, P	Nature	1994
9566877	Multiple Grb2-mediated integrin-stimulated signaling pathways to ERK2/mitogen-activated protein kinase: summation of both c-Src- and focal adhesion kinase-initiated tyrosine phosphorylation events Schlaepfer, DD, Jones, KC, Hunter, T	Mol Cell Biol	1998
12005431	The structural basis of localization and signaling by the focal adhesion targeting domain Arold, ST, Hoellerer, MK, Noble, ME	Structure	2002

Participants

Events

Participates

as an event of

Integrin signaling (Homo sapiens)

Orthologous Events

GRB2:SOS provides linkage to MAPK signaling for Integrins (Bos taurus)

GRB2:SOS provides linkage to MAPK signaling for Integrins (Caenorhabditis elegans)

GRB2:SOS provides linkage to MAPK signaling for Integrins (Canis familiaris)

GRB2:SOS provides linkage to MAPK signaling for Integrins (Danio rerio)

GRB2:SOS provides linkage to MAPK signaling for Integrins (Gallus gallus)

GRB2:SOS provides linkage to MAPK signaling for Integrins (Mus musculus)

GRB2:SOS provides linkage to MAPK signaling for Integrins (Rattus norvegicus)

GRB2:SOS provides linkage to MAPK signaling for Integrins (Sus scrofa)

Cross References

BioModels Database

BIOMD0000000175, BIOMD0000000653, BIOMD0000000466, BIOMD0000000883, BIOMD0000000255, BIOMD0000000468, BIOMD0000000340, BIOMD0000000424, BIOMD0000000019, BIOMD0000000338, BIOMD0000000399, BIOMD0000000654, BIOMD0000000655, BIOMD0000000648, BIOMD0000000652, BIOMD0000000656, BIOMD0000000339

Authored

Garapati, P V (2008-06-16)

Reviewed

Shattil, SJ (2008-09-16)

Created

Garapati, P V (2008-06-16)

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