Reactome | EIF3L [cytosol]

EIF3L [cytosol]

Stable Identifier

R-HSA-377452

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

eIF3l

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y262 EIF3L

Gene Names

EIF3L, EIF3EIP, EIF3S6IP, HSPC021, HSPC025, MSTP005

Chain

initiator methionine:, chain:2-564

Reference Genes

BioGPS Gene:51386 EIF3L

COSMIC (genes):EIF3L EIF3L

CTD Gene:51386 EIF3L

dbSNP Gene:51386 EIF3L

ENSEMBL:ENSG00000100129 EIF3L

HGNC:18138 EIF3L

KEGG:hsa:51386 EIF3L

Monarch:51386 EIF3L

NCBI Gene:51386 EIF3L

OMIM:619197 EIF3L

UCSC:Q9Y262 EIF3L

Reference Transcript

Other Identifiers

11718273_a_at

11718274_s_at

11718275_x_at

11753373_a_at

16929943

217719_PM_at

217719_at

3243631

3243634

3243635

3285646

3285649

3285651

3546453

3546454

3546457

3546463

3945057

3945058

3945059

3945060

3945061

3945062

3945063

3945064

3945065

3945066

3945067

3945068

3945069

3945071

3945072

3945073

3945077

3945078

3945079

3945080

3945081

46223_at

51386

8072946

A_14_P104527

A_23_P57521

GE58677

GO:0001650

GO:0001732

GO:0002183

GO:0003723

GO:0003743

GO:0005515

GO:0005654

GO:0005730

GO:0005737

GO:0005829

GO:0005852

GO:0006412

GO:0006413

GO:0016020

GO:0016282

GO:0032991

GO:0033290

GO:0043226

GO:0045182

GO:0045202

GO:0065003

GO:0075525

HMNXSV003057588

Hs.287757.0.S1_3p_s_at

ILMN_1762725

TC22000291.hg

g7705432_3p_at

Participates

as a component of

eIF3 subunits complex [cytosol] (Homo sapiens)

Inferred To

Ghost homologue of EIF3L [cytosol] (Saccharomyces cerevisiae)

Ghost homologue of EIF3L [cytosol] (Schizosaccharomyces pombe)

eif3L [cytosol] (Dictyostelium discoideum)

eif-3.L [cytosol] (Caenorhabditis elegans)

eIF3l [cytosol] (Drosophila melanogaster)

eif3l [cytosol] (Danio rerio)

eif3l [cytosol] (Xenopus tropicalis)

EIF3L [cytosol] (Bos taurus)

EIF3L [cytosol] (Canis familiaris)

EIF3L [cytosol] (Gallus gallus)

EIF3L [cytosol] (Plasmodium falciparum)

EIF3L [cytosol] (Sus scrofa)

Eif3l [cytosol] (Mus musculus)

Eif3l [cytosol] (Rattus norvegicus)

Cross References

OpenTargets

ENSG00000100129

ENSEMBL

ENSP00000485663, ENST00000652021, ENSG00000100129, ENSP00000371099, ENST00000624234, ENST00000381683, ENSP00000499067

HPA

ENSG00000100129-EIF3L

GeneCards

EIF3L

PRO

Q9Y262

Pharos - Targets

Q9Y262

GlyGen

Q9Y262

PDB

7A09, 8RG0, 3J8B, 8OZ0, 8PJ1, 3J8C, 9BLN, 8PJ5, 8PJ3, 8PJ2, 6ZMW, 6FEC, 8PJ4, 6ZON, 8XXN, 8PJ6, 6ZVJ, 8PPL, 6YBD, 7QP7, 7QP6, 6ZP4

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O95714 HERC2	5	HERC2 [nucleoplasm] (R-HSA-4551680) p-T4827-HERC2 [nucleoplasm] (R-HSA-5682601) p-T4827,SUMO1-HERC2 [nucleoplasm] (R-HSA-5682615) HERC2 [cytosol] (R-HSA-975975) monoSUMO1-HERC2 [nucleoplasm] (R-HSA-4551758)	0.527	2
UniProt:P10636-8 MAPT	3	MAPT-8 [cytosol] (R-HSA-9619519) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400)	0.527	5
UniProt:Q7Z4L5 TTC21B	2	TTC21B [ciliary tip] (R-HSA-5625349) TTC21B [cilium] (R-HSA-5610430)	0.508	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	9