Reactome | DARS2 [mitochondrial matrix]

DARS2 [mitochondrial matrix]

Stable Identifier

R-HSA-379679

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Aspartyl-tRNA synthetase 2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q6PI48 DARS2

Gene Names

DARS2

Chain

transit peptide:1-47, chain:48-645

Reference Genes

BioGPS Gene:55157 DARS2

COSMIC (genes):DARS2 DARS2

CTD Gene:55157 DARS2

dbSNP Gene:55157 DARS2

ENSEMBL:ENSG00000117593 DARS2

HGNC:25538 DARS2

Monarch:55157 DARS2

NCBI Gene:55157 DARS2

OMIM:610956 DARS2

UCSC:Q6PI48 DARS2

Reference Transcript

RefSeq:NM_018122.4 DARS2

Other Identifiers

11726602_at

11726603_at

16673983

218365_PM_s_at

218365_s_at

2367844

2367845

2367846

2367852

2367853

2367854

2367856

2367857

2367858

2367859

2367860

2367861

2367862

2367863

2367864

2367866

2367868

2367870

2367871

2367872

2367873

2367874

2367875

2367876

2367877

2367878

2367879

2367880

2367882

55157

64470_at

7907466

86801_at

A_14_P133617

A_23_P148984

GE55771

GO:0000049

GO:0000166

GO:0003676

GO:0003723

GO:0003824

GO:0004812

GO:0004815

GO:0005515

GO:0005524

GO:0005654

GO:0005737

GO:0005739

GO:0005759

GO:0006399

GO:0006412

GO:0006418

GO:0006422

GO:0006520

GO:0016020

GO:0016874

GO:0031966

GO:0042803

GO:0043039

GO:0043226

GO:0050560

GO:0070145

GO:0140098

HMNXSV003005910

Hs.59346.0.S1_3p_a_at

ILMN_1676191

PH_hs_0003811

TC01001516.hg

Participates

as a component of

DARS2 dimer [mitochondrial matrix] (Homo sapiens)

Cross References

ENSEMBL

ENSP00000497569, ENST00000649689

OpenTargets

ENSG00000117593

HPA

ENSG00000117593-DARS2

PRO

Q6PI48

Pharos - Targets

Q6PI48

GlyGen

Q6PI48

Orphanet

DARS2

HMDB Protein

HMDBP09252

PDB

4AH6

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P10809 HSPD1	6	HSPD1(1-573) [cytosol] (R-HSA-1267989) HSPD1(1-573) [mitochondrial intermembrane space] (R-HSA-1267963) HSPD1(1-26) [mitochondrial matrix] (R-HSA-8986171) HSPD1(1-573) [mitochondrial inner membrane] (R-HSA-1299442) HSPD1 [mitochondrial inner membrane] (R-HSA-1299455) HSPD1 [mitochondrial matrix] (R-HSA-1299448)	0.731	5
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.519	5
UniProt:Q8NFJ9 BBS1	1	BBS1 [cytosol] (R-HSA-5617640)	0.508	2

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