Reactome | CEP57 [cytosol]

CEP57 [cytosol]

Stable Identifier

R-HSA-380271

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Cep57

Locations in the PathwayBrowser

Expand all

Organelle biogenesis and maintenance (Homo sapiens)

- Cilium Assembly (Homo sapiens)
  - Anchoring of the basal body to the plasma membrane (Homo sapiens)
    - C2CD3 and OFD1 recruit 5 distal appendage proteins to the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
    - C2CD3 binds the mother centriole (Homo sapiens)
      - mother centriole [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
      - mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
    - CEP164 recruits RAB3IP-carrying Golgi-derived vesicles to the basal body (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
    - CP110 and CEP97 dissociate from the centriole (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
    - MARK4 binds ODF2 in the centriole (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
      - centrosome:C2CD2:distal appendage proteins:TTBK2:MARK4 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
    - RAB3IP stimulates nucleotide exchange on RAB8A (Homo sapiens)
      - basal body:transition zone proteins:RAB3IP:RAB11A:GTP:Golgi-derived vesicle [cytosol] (Homo sapiens)
        
        basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
    - Recruitment of transition zone proteins (Homo sapiens)
      - basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
      - basal body:transition zone proteins [cytosol] (Homo sapiens)
        
        basal body [cytosol] (Homo sapiens)
        
        centrosome without CEP164, CCP110 or CEP97 [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
    - The distal appendage proteins recruit TTBK2 (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)
      - Centrosome:C2CD3:distal appendage proteins:TTBK2 [cytosol] (Homo sapiens)
        
        Centrosome:C2CD3:distal appendage proteins [cytosol] (Homo sapiens)
        
        mother centriole:C2CD3 [cytosol] (Homo sapiens)
        
        mother centriole [cytosol] (Homo sapiens)
        
        CEP57 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q86XR8 CEP57

Gene Names

CEP57, KIAA0092, TSP57

Chain

chain:1-500

Reference Genes

BioGPS Gene:9702 CEP57

COSMIC (genes):CEP57 CEP57

CTD Gene:9702 CEP57

dbSNP Gene:9702 CEP57

ENSEMBL:ENSG00000166037 CEP57

ENSEMBL_homo_sapiens_GENE:ENSG00000166037.11 CEP57

HGNC:30794 CEP57

KEGG Gene (Homo sapiens):9702 CEP57

Monarch:9702 CEP57

NCBI Gene:9702 CEP57

OMIM:607951 CEP57

UCSC:Q86XR8 CEP57

Reference Transcript

Other Identifiers

11743541_a_at

11743542_s_at

11743543_x_at

11743544_a_at

11748252_s_at

11759668_a_at

11759669_x_at

11759670_a_at

11763342_s_at

16730340

203491_PM_s_at

203491_s_at

203492_PM_x_at

203492_x_at

203493_PM_s_at

203493_s_at

203494_PM_s_at

203494_s_at

209862_PM_s_at

209862_s_at

3345598

3345599

3345600

3345606

3345607

3345612

3345614

3345617

3345619

3345621

3345622

3345623

3345624

3345625

3345627

3345628

3345630

3345631

3345632

3345633

3345634

3345636

39785_at

67124_at

7943297

82224_at

9702

A_14_P101088

A_14_P121200

A_14_P129165

A_23_P86822

A_24_P145124

D42054_at

GE57206

GE86546

GO:0005515

GO:0005634

GO:0005737

GO:0005794

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005874

GO:0007286

GO:0008017

GO:0008092

GO:0008543

GO:0017134

GO:0022414

GO:0023052

GO:0030154

GO:0034451

GO:0042802

GO:0042803

GO:0043015

GO:0043226

GO:0048856

GO:0051260

GO:0065003

HMNXSV003021150

Hs.151791.0.S1_3p_s_at

Hs.151791.0.S2_3p_a_at

Hs.151791.0.S3_3p_a_at

ILMN_1791568

PH_hs_0035506

TC11000933.hg

g12654780_3p_s_at

g7661899_3p_a_at

Participates

as a component of

Inferred To

CEP57 [cytosol] (Bos taurus)

CEP57 [cytosol] (Canis familiaris)

CEP57 [cytosol] (Gallus gallus)

CEP57 [cytosol] (Sus scrofa)

cep57 [cytosol] (Xenopus tropicalis)

Cep57 [cytosol] (Mus musculus)

Cep57 [cytosol] (Rattus norvegicus)

Cross References

RefSeq

XP_016874081.1, NP_001230706.1, NP_055494.2, NP_001230705.1

OpenTargets

ENSG00000166037

HPA

ENSG00000166037-CEP57

GeneCards

Q86XR8

Ensembl

ENSP00000317902, ENSG00000166037, ENST00000541150, ENSP00000445706, ENSP00000317487, ENST00000538658, ENST00000325486, ENSP00000443436, ENST00000325542

PRO

Q86XR8

Pharos - Targets

Q86XR8

Orphanet

20281

PDB

4L0R

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q9UBB9 TFIP11	1	TFIP11 [nucleoplasm] (R-HSA-8869310)	0.666	4
UniProt:Q96PC5 MIA2	1	MIA2 [endoplasmic reticulum membrane] (R-HSA-9637821)	0.556	3
UniProt:P01106 MYC	2	PolyUb-MYC [nucleoplasm] (R-HSA-6783169) MYC [nucleoplasm] (R-HSA-188379)	0.524	3
UniProt:P05919 vpu	6	VPU (P05919) protein [cytosol] (R-HIV-173223) VPU (P05919) [endoplasmic reticulum membrane] (R-HIV-180550) VPU (P05919) protein [extracellular region] (R-HIV-175522) VPU (P05919) protein [nucleoplasm] (R-HIV-175200) VPU (P05919) [Golgi membrane] (R-HIV-3149439) VPU (P05919) [plasma membrane] (R-HIV-3149423)	0.462	2

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