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monoSUMO1-K239,K731,K788-NCOA2 [nucleoplasm]
Stable Identifier
R-HSA-4085305
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
NCOA2_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of transcription cofactors (Homo sapiens)
SUMOylation of NCOA2 with SUMO1 (Homo sapiens)
monoSUMO1-K239,K731,K788-NCOA2 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q15596 NCOA2
Gene Names
NCOA2, BHLHE75, SRC2, TIF2
Chain
initiator methionine:, chain:2-1464
Reference Genes
BioGPS Gene:10499 NCOA2
COSMIC (genes):NCOA2 NCOA2
CTD Gene:10499 NCOA2
dbSNP Gene:10499 NCOA2
ENSEMBL:ENSG00000140396 NCOA2
HGNC:7669 NCOA2
KEGG:hsa:10499 NCOA2
Monarch:10499 NCOA2
NCBI Gene:10499 NCOA2
OMIM:601993 NCOA2
UCSC:Q15596 NCOA2
Reference Transcript
RefSeq:NM_001321703.1 NCOA2
RefSeq:NM_001321707.1 NCOA2
RefSeq:NM_001321712.1 NCOA2
RefSeq:NM_006540.3 NCOA2
RefSeq:NM_001321713.1 NCOA2
RefSeq:NM_001321711.1 NCOA2
Other Identifiers
10499
11739713_at
11739714_a_at
11739715_at
17078061
205731_PM_s_at
205731_s_at
205732_PM_s_at
205732_s_at
212867_PM_at
212867_at
3139723
3139724
3139725
3139726
3139733
3139734
3139735
3139736
3139737
3139738
3139739
3139741
3139743
3139744
3139747
3139748
3139750
3139753
3139756
3139761
3139762
3139763
3139764
3139766
3139768
3139770
3139775
3139777
3139787
3139788
3139803
3139804
3139815
3139843
3139844
3139845
3139846
3139847
3139848
3139851
3139852
3139853
3139856
34312_at
34313_at
8151254
A_23_P428999
A_24_P166794
A_33_P3270019
GE480764
GE60195
GO:0000122
GO:0000785
GO:0000978
GO:0001162
GO:0003677
GO:0003682
GO:0003713
GO:0005102
GO:0005515
GO:0005634
GO:0005654
GO:0005667
GO:0005737
GO:0006351
GO:0006355
GO:0007623
GO:0010468
GO:0010906
GO:0016071
GO:0016604
GO:0016922
GO:0017162
GO:0019216
GO:0019904
GO:0030374
GO:0032570
GO:0032870
GO:0032922
GO:0032991
GO:0035357
GO:0042789
GO:0043226
GO:0045475
GO:0045892
GO:0045893
GO:0045944
GO:0046983
GO:0048511
GO:0060090
GO:0061629
GO:0090575
GO:0140110
GO:1900076
GO:1904017
GO:1904179
HMNXSV003054540
Hs.29131.0.S1_3p_a_at
Hs.29131.1.S1_3p_at
ILMN_1769040
PH_hs_0026126
TC08001310.hg
TC08002375.hg
X97674_at
g5729857_3p_a_at
Participates
as an output of
SUMOylation of NCOA2 with SUMO1 (Homo sapiens)
Other forms of this molecule
NCOA2 [nucleoplasm]
NCOA2 (869-1464) [nucleoplasm]
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 239
Coordinate
239
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 731
Coordinate
731
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 788
Coordinate
788
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_001308640.1
,
NP_001308641.1
,
NP_001308642.1
,
NP_001308632.1
,
NP_006531.1
,
NP_001308636.1
Guide to Pharmacology - Targets
2694
OpenTargets
ENSG00000140396
ENSEMBL
ENSP00000399968
,
ENST00000452400
HPA
ENSG00000140396-NCOA2
PRO
Q15596
Pharos - Targets
Q15596
GlyGen
Q15596
PDB
5LGA
,
4PLD
,
1M2Z
,
4UDC
,
4ZNS
,
7T2X
,
4PP6
,
5NFP
,
5KCT
,
5KRF
,
5G43
,
7WMG
,
5DKG
,
7OFK
,
4POH
,
3L0J
,
4Q13
,
7RAF
,
5TMO
,
5TN8
,
4DOS
,
5KRK
,
5KRC
,
4ZN9
,
5EGV
,
7WLX
,
6EL6
,
7RKE
,
8C1L
,
4RMD
,
5TML
,
6KNW
,
5TN3
,
5TM7
,
2YJD
,
5LYQ
,
4IV4
,
7JYE
,
6STI
,
5DI7
,
8PZ9
,
4ZO1
,
5KD9
,
5SYZ
,
5WZX
,
5APH
,
4IA7
,
1GWR
,
1MV9
,
4IWC
,
4ZNW
,
5DKB
,
9EZ1
,
4PP3
,
5DWG
,
5Y49
,
7KCO
,
6OR1
,
2FAI
,
5TMW
,
4M8E
,
5TM3
,
1MZN
,
5VB6
,
5TLF
,
5KCC
,
5DU5
,
5TMM
,
4ZN7
,
5TLY
,
2ZY0
,
5TMR
,
5DZI
,
7JHD
,
5TLV
,
7JYD
,
5DIG
,
3E00
,
5DYD
,
5DXP
,
5DY8
,
5EC9
,
8PZ8
,
5U2D
,
5DXB
,
4UDD
,
5L11
,
3DZY
,
5UAN
,
7TT8
,
3L0E
,
2LDC
,
5EHJ
,
5KCW
,
5NI8
,
5KCE
,
7B9O
,
5T1Z
,
5Z12
,
3DZU
,
5YXD
,
5NI5
,
5TLD
,
5NFT
,
7BK4
,
6OQY
,
6EL7
,
4RME
,
5TMV
,
8F8M
,
5TMQ
,
7B88
,
5E15
,
5TM5
,
4CSJ
,
4PXM
,
5DXK
,
5TN6
,
5TLM
,
5TLU
,
5DXR
,
2B1V
,
4IVW
,
4IVY
,
6VIF
,
5DZ0
,
5DX3
,
8PZ7
,
4PLE
,
4ZNH
,
4IU7
,
4ZNT
,
3O1E
,
3OAP
,
7YMK
,
6LB5
,
5KCF
,
6ESN
,
3L0L
,
5DUH
,
1GWQ
,
5APJ
,
6LIT
,
5G42
,
6CZN
,
7WMH
,
7W3P
,
4IQR
,
7PDQ
,
5DLR
,
5TLG
,
5KRJ
,
7WMO
,
6R7K
,
4IA3
,
5TM2
,
1T65
,
2P1T
,
7WMJ
,
5G46
,
5VB5
,
5E14
,
5TLT
,
4PPS
,
4E2J
,
5TMU
,
3UP0
,
6VC2
,
4NIE
,
5DMF
,
3CLD
,
4IW6
,
5Y1J
,
8PZ6
,
5MK4
,
7UW2
,
2G5O
,
5YP5
,
3GN8
,
7NEL
,
4IWF
,
5E1C
,
4NQA
,
5KRM
,
6KKB
,
5DL4
,
5EI1
,
4ZSH
,
2Q7L
,
5NIB
,
6LB6
,
5DVV
,
7A77
,
6EL9
,
5TM1
,
5G44
,
4K4J
,
4IA1
,
4POJ
,
3KWY
,
6R7A
,
7APO
,
5E0X
,
5KR9
,
7WMN
,
1ZDU
,
4WG0
,
8PZB
,
5YXJ
,
5VQL
,
5TLX
,
3K22
,
5DXQ
,
4QE8
,
5TN5
,
3Q95
,
3UP3
,
5DZ3
,
3E94
,
7VUE
,
7UW4
,
6SJM
,
1ZKY
,
5EIT
,
5DTV
,
7D42
,
3ERD
,
4ZNU
,
5DKS
,
2P15
,
4RUO
,
6HL1
,
6LB4
,
2G44
,
5DVS
,
5KRA
,
5KRI
,
7NKE
,
7A78
,
9EZ2
,
3KYT
,
6OQX
,
5TLP
,
4P6W
,
5NI7
,
3R5M
,
5G45
,
3OZJ
,
5TN7
,
1T63
,
5TN1
,
5DRM
,
5TM4
,
5VB7
,
5E0W
,
5VQK
,
5DRJ
,
5TM6
,
5TMT
,
4IUI
,
4IW8
,
5Q17
,
3A9E
,
5DZ1
,
5XPL
,
8VKZ
,
4OC7
,
8DAF
,
7RAE
,
4K6I
,
4PP5
,
5DXG
,
5G5W
,
2ZXZ
,
6KKE
,
2Q7J
,
5KRO
,
5TLL
,
1UHL
,
3PCU
,
5DUE
,
5DWE
,
3E7C
,
5YXL
,
5G3J
,
5DKE
,
7A79
,
4IA2
,
4Q0A
,
2P1U
,
5KCD
,
8EV2
,
6KNU
,
6R7J
,
4RMC
,
5DMC
,
5TN4
,
5TM8
,
5YXB
,
5WGQ
,
2B23
,
5ICK
,
7NFB
,
5DYB
,
5DID
,
5DWJ
,
1MVC
,
4RFW
,
4FHI
,
5KCU
,
5H1E
,
5DXE
,
5DUG
,
4M8H
,
5I4V
,
5KRL
,
1YOK
,
4ZNV
,
7W3Q
,
7OFI
,
4P6X
,
8PP0
,
3FUG
,
7PDT
,
2AO6
,
3O1D
,
4PPP
,
5TLO
,
5VB3
,
6D0F
,
5KRH
,
7SFO
,
2P1V
,
7WML
,
8EV1
,
1P93
,
2B1Z
,
6KNV
,
5DP0
,
5E19
,
1ZDT
,
3PLZ
,
5TMZ
,
5TMS
,
5TM9
,
3K23
,
5DZH
,
5IAW
,
4IV2
,
5DXM
,
5DIE
,
5DWI
,
4FHH
,
5HYR
,
5DK9
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19793 RXRA
4
RXRA [nucleoplasm]
(R-HSA-381319)
monoSUMO1-K108-RXRA [nucleoplasm]
(R-HSA-4341130)
p-S21-RXRA [nucleoplasm]
(R-HSA-5334811)
RXRA [cytosol]
(R-HSA-9619757)
0.775
5
UniProt:P10275 AR
4
AR [cytosol]
(R-HSA-5618082)
AR [nucleoplasm]
(R-HSA-446174)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
0.692
4
UniProt:P43363 MAGAA
0.643
3
UniProt:Q13239 SLA
1
SLA [cytosol]
(R-HSA-9706158)
0.589
2
UniProt:P03372 ESR1
10
ESR1 [cytosol]
(R-HSA-9020968)
ESR1 [nucleoplasm]
(R-HSA-446168)
Me260-PalmS-ESR1 [plasma membrane]
(R-HSA-9637788)
PalmS-ESR1 [plasma membrane]
(R-HSA-9021057)
PalmS-ESR1 [cytosol]
(R-HSA-9020974)
Me260-ESR1 [cytosol]
(R-HSA-9632177)
p-S167-ESR1 [cytosol]
(R-HSA-9841254)
p-S167-ESR1 [nucleoplasm]
(R-HSA-9841867)
monoSUMO1-5K-ESR1 [nucleoplasm]
(R-HSA-4090302)
p-S118-ESR1 [nucleoplasm]
(R-HSA-9024210)
0.584
5
UniProt:O00482-1 NR5A2
1
NR5A2-1 [nucleoplasm]
(R-HSA-3008758)
0.558
2
UniProt:P11473 VDR
2
VDR [nucleoplasm]
(R-HSA-375512)
polySUMO2-VDR [nucleoplasm]
(R-HSA-4546376)
0.524
2
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