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monoSUMO1-K386,520-AR [nucleoplasm]
Stable Identifier
R-HSA-4090320
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
Androgen receptor, ANDR_HUMAN
Locations in the PathwayBrowser
Expand all
Metabolism of proteins (Homo sapiens)
Post-translational protein modification (Homo sapiens)
SUMOylation (Homo sapiens)
SUMO E3 ligases SUMOylate target proteins (Homo sapiens)
SUMOylation of intracellular receptors (Homo sapiens)
PIAS1,2-1 SUMOylates AR with SUMO1 (Homo sapiens)
monoSUMO1-K386,520-AR [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P10275 AR
Gene Names
AR, DHTR, NR3C4
Chain
chain:1-920
Reference Genes
BioGPS Gene:367 AR
COSMIC (genes):AR AR
CTD Gene:367 AR
dbSNP Gene:367 AR
ENSEMBL:ENSG00000169083 AR
ENSEMBL_homo_sapiens_GENE:ENSG00000169083.18 AR
HGNC:644 AR
KEGG Gene (Homo sapiens):367 AR
Monarch:367 AR
NCBI Gene:367 AR
OMIM:313700 AR
UCSC:P10275 AR
Reference Transcript
RefSeq:NM_001011645.3 AR
RefSeq:NM_001348064.1 AR
RefSeq:NM_001348061.1 AR
RefSeq:NM_001348063.1 AR
RefSeq:NM_000044.4 AR
Other Identifiers
11737903_a_at
11742471_a_at
11752265_a_at
11762394_a_at
1577_at
1578_g_at
17104313
211110_PM_s_at
211110_s_at
226192_PM_at
226192_at
226197_PM_at
226197_at
367
3979915
3979916
3979917
3979918
3979919
3979920
3979921
3979922
3979923
3979924
3979925
3979926
3979927
3979928
3979929
3979930
3979931
3979932
3979933
3979934
3979955
3979956
3979964
3979968
3979970
3979971
3979972
3979973
3979975
3979977
3979978
3979979
3979980
3979981
3979982
3979983
3979988
3979989
3979990
3979992
43435_at
43436_g_at
52851_at
52853_g_at
8167998
A_14_P120121
A_14_P201842
A_23_P113111
GE58203
GE87814
GO:0000122
GO:0000165
GO:0000785
GO:0000976
GO:0000978
GO:0000981
GO:0001091
GO:0001223
GO:0001228
GO:0001701
GO:0003013
GO:0003073
GO:0003382
GO:0003677
GO:0003682
GO:0003700
GO:0004879
GO:0004930
GO:0005102
GO:0005496
GO:0005497
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0005886
GO:0006351
GO:0006355
GO:0006357
GO:0006366
GO:0007165
GO:0007186
GO:0007267
GO:0007283
GO:0007338
GO:0008013
GO:0008270
GO:0008284
GO:0008285
GO:0008289
GO:0008584
GO:0009566
GO:0010468
GO:0010628
GO:0012501
GO:0016607
GO:0019102
GO:0019899
GO:0022414
GO:0023052
GO:0030154
GO:0030518
GO:0030520
GO:0030521
GO:0030522
GO:0032991
GO:0033148
GO:0033327
GO:0034056
GO:0035264
GO:0042327
GO:0043226
GO:0043410
GO:0043565
GO:0043568
GO:0045597
GO:0045720
GO:0045726
GO:0045893
GO:0045944
GO:0045945
GO:0046872
GO:0048009
GO:0048608
GO:0048638
GO:0048645
GO:0048808
GO:0048856
GO:0050673
GO:0050680
GO:0051092
GO:0051117
GO:0060089
GO:0060090
GO:0060520
GO:0060571
GO:0060599
GO:0060685
GO:0060736
GO:0060740
GO:0060742
GO:0060748
GO:0060749
GO:0060769
GO:0061024
GO:0061458
GO:0061629
GO:0070974
GO:0071383
GO:0071391
GO:0071394
GO:0072520
GO:0072659
GO:0140110
GO:1902895
GO:1903076
GO:1990837
GO:2001237
HMNXSV003053460
Hs.76704.0.A1_3p_at
Hs.76704.0.A2_3p_at
ILMN_1659572
ILMN_1767351
M23263_at
M35851_s_at
PH_hs_0005583
TC0X000358.hg
g178655_3p_at
g5639998_3p_s_at
Participates
as an output of
PIAS1,2-1 SUMOylates AR with SUMO1 (Homo sapiens)
Other forms of this molecule
PolyUb-AR [nucleoplasm]
AR [nucleoplasm]
AR [cytosol]
Inferred To
AR [nucleoplasm]
(Bos taurus)
AR [nucleoplasm]
(Gallus gallus)
AR [nucleoplasm]
(Sus scrofa)
monoSUMO1-K386,520-AR [nucleoplasm]
(Mus musculus)
monoSUMO1-K386,520-AR [nucleoplasm]
(Rattus norvegicus)
ar [nucleoplasm]
(Danio rerio)
ar [nucleoplasm]
(Xenopus tropicalis)
Modified Residues
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 386
Coordinate
386
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Name
sumoylated lysine (monoSUMO1 [nucleoplasm]) at 520
Coordinate
520
Modification
monoSUMO1 [nucleoplasm]
PsiMod Name
sumoylated lysine
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a sumo (Small Ubiquitin-related MOdifier) protein.
Cross References
RefSeq
NP_000035.2
,
NP_001334992.1
,
NP_001011645.1
,
NP_001334990.1
,
NP_001334993.1
ZINC - World Drugs
ANDR_HUMAN
Guide to Pharmacology - Targets
628
OpenTargets
ENSG00000169083
ZINC - FDA approved
ANDR_HUMAN
ZINC - Substances
ANDR_HUMAN
ZINC target
P10275
ZINC - Biogenic
ANDR_HUMAN
PRO
P10275
PDB
2PIR
,
2HVC
,
4OJB
,
8FH1
,
2AX7
,
8FGY
,
8FGZ
,
3B67
,
4OKW
,
2Q7K
,
3L3Z
,
4OKX
,
8FH2
,
2YLO
,
3B66
,
4OH6
,
4OFR
,
2PIW
,
1Z95
,
3L3X
,
1XOW
,
2PIP
,
2Z4J
,
4OIL
,
2PIV
,
2YHD
,
2AMB
,
4OLM
,
5VO4
,
4OIU
,
5CJ6
,
5T8E
,
2PIO
,
3V4A
,
1XQ3
,
8RM7
,
8E1A
,
7ZU1
,
5T8J
,
4OEZ
,
3RLL
,
2YLQ
,
1T63
,
4OJ9
,
2OZ7
,
2AMA
,
8FH0
,
2PIT
,
4OGH
,
4OEA
,
4OKT
,
4K7A
,
2YLP
,
3RLJ
,
5V8Q
,
1GS4
,
2AM9
,
2PKL
,
2AX6
,
2PIX
,
5JJM
,
4OED
,
2AXA
,
3B65
,
2Q7J
,
3ZQT
,
4OH5
,
2PIQ
,
4OK1
,
4HLW
,
2PNU
,
4QL8
,
3V49
,
2Q7I
,
3B5R
,
1E3G
,
1XJ7
,
4OFU
,
2PIU
,
4OHA
,
1T65
,
4OEY
,
4OKB
,
2AX9
,
2AX8
,
7ZTX
,
8RM6
,
3BTR
,
2AO6
,
1T5Z
,
3B68
,
2Q7L
,
7ZU2
,
7ZTZ
ZINC - Investigational
ANDR_HUMAN
ZINC - Metabolites
ANDR_HUMAN
HPA
ENSG00000169083-AR
GeneCards
P10275
Ensembl
ENSP00000484033
,
ENSP00000421155
,
ENST00000504326
,
ENST00000612452
,
ENSG00000169083
,
ENSP00000363822
,
ENST00000374690
Pharos - Targets
P10275
ZINC - Predictions - Purchasable
ANDR_HUMAN
Orphanet
16667
HMDB Protein
HMDBP01624
Interactors (54)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
IntAct:EBI-1776214 KLK3
0.922
18
UniProt:P35222 CTNNB1
20
CTNNB1 S45A [cytosol]
(R-HSA-9663982)
CTNNB1 S45F [cytosol]
(R-HSA-4791268)
CTNNB1 S45C [cytosol]
(R-HSA-9663983)
CTNNB1 S45Y [cytosol]
(R-HSA-9663975)
CTNNB1 S45N [cytosol]
(R-HSA-9663984)
CTNNB1 S45P [cytosol]
(R-HSA-4791272)
pT41,S45-CTNNB1 S37P [cytosol]
(R-HSA-9663981)
pT41,S45-CTNNB1 S37F [cytosol]
(R-HSA-4839621)
pT41,S45-CTNNB1 S37A [cytosol]
(R-HSA-4839619)
pT41,S45-CTNNB1 S37Y [cytosol]
(R-HSA-9663978)
pT41,S45-CTNNB1 S37C [cytosol]
(R-HSA-4839617)
pS37,T41,S45-CTNNB1 S33A [cytosol]
(R-HSA-9663976)
pS37,T41,S45-CTNNB1 S33T [cytosol]
(R-HSA-9663977)
pS37,T41,S45-CTNNB1 S33C [cytosol]
(R-HSA-4839630)
pS37,T41,S45-CTNNB1 S33F [cytosol]
(R-HSA-4839628)
pS37,T41,S45-CTNNB1 S33P [cytosol]
(R-HSA-4839626)
pS37,T41,S45-CTNNB1 S33Y [cytosol]
(R-HSA-4839625)
pS45-CTNNB1 T41N [cytosol]
(R-HSA-9663980)
pS45-CTNNB1 T41A [cytosol]
(R-HSA-4836868)
pS45-CTNNB1 T41I [cytosol]
(R-HSA-4839612)
0.891
15
IntAct:EBI-2602074 TMPS2
0.886
13
UniProt:P55317 FOXA1
1
FOXA1 [nucleoplasm]
(R-HSA-453074)
0.713
4
UniProt:Q15596 NCOA2
3
monoSUMO1-K239,K731,K788-NCOA2 [nucleoplasm]
(R-HSA-4085305)
NCOA2 (869-1464) [nucleoplasm]
(R-HSA-5603186)
NCOA2 [nucleoplasm]
(R-HSA-376398)
0.692
4
UniProt:P11308 ERG
0.688
4
UniProt:O60885-1 BRD4
0.682
6
IntAct:EBI-2677345 NDRG1
0.669
4
UniProt:Q03164 KMT2A
6
KMT2A [cytosol]
(R-HSA-9818584)
KMT2A(2719-3969) [cytosol]
(R-HSA-9818590)
KMT2A(1-2718) [cytosol]
(R-HSA-9818597)
KMT2A [nucleoplasm]
(R-HSA-1183223)
KMT2A(1-2718) [nucleoplasm]
(R-HSA-9818591)
KMT2A(2719-3969) [nucleoplasm]
(R-HSA-9818593)
0.667
4
UniProt:Q15652 JMJD1C
1
JMJD1C [nucleoplasm]
(R-HSA-997258)
0.637
4
UniProt:Q92793 CREBBP
4
monoSUMO1-K998,K1033,K1056-CREBBP [nucleoplasm]
(R-HSA-3927877)
FOXO4-S-S-CREBBP [nucleoplasm]
(R-HSA-9617684)
CREBBP [cytosol]
(R-HSA-9756493)
CREBBP [nucleoplasm]
(R-HSA-193545)
0.628
3
UniProt:Q9UER7 DAXX
13
monoSUMO1-K630,K631-DAXX [nucleoplasm]
(R-HSA-4086086)
DAXX L98Vfs*13 [nucleoplasm]
(R-HSA-9673102)
DAXX R48Vfs*93 [nucleoplasm]
(R-HSA-9673103)
DAXX C74* [nucleoplasm]
(R-HSA-9673096)
DAXX S138* [nucleoplasm]
(R-HSA-9673081)
DAXX H26Tfs*118 [nucleoplasm]
(R-HSA-9673114)
DAXX E104* [nucleoplasm]
(R-HSA-9673078)
DAXX E72Nfs*72 [nucleoplasm]
(R-HSA-9673110)
DAXX C106* [nucleoplasm]
(R-HSA-9673079)
DAXX A103Sfs*40 [nucleoplasm]
(R-HSA-9673121)
DAXX K56* [nucleoplasm]
(R-HSA-9673089)
DAXX A36Qfs*108 [nucleoplasm]
(R-HSA-9673105)
DAXX [nucleoplasm]
(R-HSA-3222068)
0.625
5
UniProt:Q14686 NCOA6
1
NCOA6 [nucleoplasm]
(R-HSA-376414)
0.618
3
UniProt:O14686 KMT2D
1
KMT2D [nucleoplasm]
(R-HSA-1183219)
0.604
3
UniProt:P07288 KLK3
1
KLK3 [extracellular region]
(R-HSA-381416)
0.604
3
UniProt:Q9UBL3 ASH2L
1
ASH2L [nucleoplasm]
(R-HSA-1629834)
0.604
3
UniProt:Q15797 SMAD1
4
Ub-SMAD1 [cytosol]
(R-HSA-6782768)
SMAD1 [cytosol]
(R-HSA-201468)
p-S463,S465-SMAD1 [cytosol]
(R-HSA-201464)
p-S463,S465-SMAD1 [nucleoplasm]
(R-HSA-201483)
0.602
6
UniProt:O96028 NSD2
2
p-S102-WHSC1 [nucleoplasm]
(R-HSA-5682984)
WHSC1 [nucleoplasm]
(R-HSA-1183215)
0.602
5
UniProt:Q99497 PARK7
7
monoSUMO1-K130-PARK7 [nucleoplasm]
(R-HSA-4085351)
PARK7 [nucleoplasm]
(R-HSA-3900141)
PolyUb-Misfolded PARK7 [late endosome lumen]
(R-HSA-9660005)
Misfolded PARK7 [cytosol]
(R-HSA-9641100)
Ub-Misfolded PARK7 [cytosol]
(R-HSA-9641123)
PolyUb-Misfolded PARK7 [cytosol]
(R-HSA-9641128)
PolyUb-Misfolded PARK7 [lysosomal lumen]
(R-HSA-9659997)
0.602
6
UniProt:P63165 SUMO1
11
lysyl-G97-SUMO1 [plasma membrane]
(R-HSA-9762382)
lysyl-G97-SUMO1 [nucleolus]
(R-HSA-9762385)
lysyl-G97-SUMO1 [viral capsid]
(R-HSA-9762386)
UBE2I-G97-SUMO1 [cytosol]
(R-HSA-4656941)
lysyl-G97-SUMO1 [endoplasmic reticulum-Golgi intermediate compartment membrane]
(R-HSA-9762380)
lysyl-G97-SUMO1 [cytosol]
(R-HSA-9762266)
UBE2I-G97-SUMO1 [nucleoplasm]
(R-HSA-3730622)
UBA2-G97-SUMO1 [nucleoplasm]
(R-HSA-3730616)
SUMO1 [nucleoplasm]
(R-HSA-877304)
SUMO1(2-101) [nucleoplasm]
(R-HSA-2990831)
lysyl-G97-SUMO1 [nucleoplasm]
(R-HSA-9761562)
0.602
7
UniProt:O95251 KAT7
1
KAT7 [nucleoplasm]
(R-HSA-3321823)
0.593
5
UniProt:Q9R1E0 Foxo1
6
phospho-Foxo1 [nucleoplasm]
(R-MMU-5692651)
Ac-K242,K245,K262-Foxo1 [nucleoplasm]
(R-MMU-9626941)
phospho-Foxo1 [cytosol]
(R-MMU-211158)
phospho-Foxo1 [nucleoplasm]
(R-MMU-199306)
Foxo1 [nucleoplasm]
(R-MMU-187293)
Foxo1 [nucleoplasm]
(R-MMU-199300)
0.592
4
UniProt:Q9Y252 RNF6
1
RNF6 [cytosol]
(R-HSA-975997)
0.584
10
UniProt:O14595 CTDSP2
1
CTDSP2 [nucleoplasm]
(R-HSA-535488)
0.581
3
UniProt:Q06986
1
SIAH2 [cytosol]
(R-MMU-374566)
0.576
6
UniProt:O75376 NCOR1
2
NCOR1 [cytosol]
(R-HSA-1253310)
NCOR1 [nucleoplasm]
(R-HSA-442501)
0.569
4
IntAct:EBI-2678840 FKBP5
0.564
2
UniProt:Q15910 EZH2
1
EZH2 [nucleoplasm]
(R-HSA-212298)
0.564
2
UniProt:P10275 AR
4
PolyUb-AR [nucleoplasm]
(R-HSA-6782984)
monoSUMO1-K386,520-AR [nucleoplasm]
(R-HSA-4090320)
AR [nucleoplasm]
(R-HSA-446174)
AR [cytosol]
(R-HSA-5618082)
0.547
2
UniProt:P24385 CCND1
4
CCND1 [nucleoplasm]
(R-HSA-113832)
CCND1 [cytosol]
(R-HSA-68328)
p-T286-CCND1 [nucleoplasm]
(R-HSA-75811)
p-T286-CCND1 [cytosol]
(R-HSA-75813)
0.544
4
UniProt:Q06830 PRDX1
3
p-T90-PRDX1 [cytosol]
(R-HSA-8868564)
PRDX1 [cytosol]
(R-HSA-3341270)
HOOS-C52-PRDX1 [cytosol]
(R-HSA-5629198)
0.544
3
UniProt:P56524 HDAC4
3
polySUMO2,3-K559-HDAC4 [nucleoplasm]
(R-HSA-4616029)
monoSUMO1-K559-HDAC4 [nucleoplasm]
(R-HSA-4616016)
HDAC4 [nucleoplasm]
(R-HSA-351581)
0.544
4
UniProt:P20794 MAK
0.537
5
UniProt:Q9NSA3 CTNNBIP1
1
CTNNBIP1 [nucleoplasm]
(R-HSA-3772388)
0.532
4
UniProt:P06396 GSN
7
GSN(200-270) [extracellular region]
(R-HSA-976940)
GSN [secretory granule lumen]
(R-HSA-6801486)
GSN [extracellular region]
(R-HSA-6806510)
GSN [ficolin-1-rich granule lumen]
(R-HSA-6801465)
GSN(404-782) [cytosol]
(R-HSA-350272)
GSN(28-403) [cytosol]
(R-HSA-201618)
GSN [cytosol]
(R-HSA-350275)
0.527
2
UniProt:Q9BY66-3 KDM5D
0.524
2
UniProt:P78543 BTG2
1
BTG2 [cytosol]
(R-HSA-6798008)
0.524
4
UniProt:Q16666 IFI16
1
IFI16 [cytosol]
(R-HSA-1834934)
0.524
3
UniProt:Q15788 NCOA1
3
monoSUMO1-K732,K774-NCOA1 [nucleoplasm]
(R-HSA-4085291)
NCOA1 (868-1441) [nucleoplasm]
(R-HSA-5603230)
NCOA1 [nucleoplasm]
(R-HSA-442496)
0.519
2
UniProt:Q14192 FHL2
1
FHL2 [nucleoplasm]
(R-HSA-561161)
0.508
2
UniProt:Q92993 KAT5
1
KAT5 [nucleoplasm]
(R-HSA-3321979)
0.508
2
UniProt:P20711 DDC
1
PXLP-DDC [cytosol]
(R-HSA-209810)
0.508
2
UniProt:O75593 FOXH1
1
FOXH1 [nucleoplasm]
(R-HSA-1225914)
0.508
3
UniProt:P78527 PRKDC
4
K48polyUb-PRKDC [cytosol]
(R-HSA-8938766)
PRKDC [cytosol]
(R-HSA-3134816)
p-T2609,S2612,T2638,T2647-PRKDC [nucleoplasm]
(R-HSA-76302)
PRKDC [nucleoplasm]
(R-HSA-62161)
0.499
3
UniProt:Q9UBS8 RNF14
1
RNF14 [cytosol]
(R-HSA-5688974)
0.499
2
UniProt:Q02790 FKBP4
3
FKBP4 [nucleoplasm]
(R-HSA-8939162)
FKBP4 [nucleoplasm]
(R-HSA-5324621)
FKBP4 [cytosol]
(R-HSA-5618108)
0.499
2
UniProt:Q9Y6Q9 NCOA3
2
NCOA3 [nucleoplasm]
(R-HSA-442488)
p-S857 NCOA3 [nucleoplasm]
(R-HSA-5687005)
0.483
3
UniProt:Q9NPF5 DMAP1
1
DMAP1 [nucleoplasm]
(R-HSA-212166)
0.471
2
UniProt:Q15648 MED1
1
MED1 [nucleoplasm]
(R-HSA-212445)
0.471
2
UniProt:Q93074 MED12
1
MED12 [nucleoplasm]
(R-HSA-212343)
0.471
2
UniProt:O43474 KLF4
1
KLF4 [nucleoplasm]
(R-HSA-434463)
0.471
2
UniProt:Q6KC79 NIPBL
1
NIPBL [nucleoplasm]
(R-HSA-2506879)
0.471
2
UniProt:Q9Y253 POLH
2
MonoUb-K682,K686,K694,K709-POLH [nucleoplasm]
(R-HSA-5655163)
POLH [nucleoplasm]
(R-HSA-110287)
0.471
2
UniProt:P17535 JUND
1
JUND [nucleoplasm]
(R-HSA-9009924)
0.454
2
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