Reactome | MYH10 [cytosol]

MYH10 [cytosol]

Stable Identifier

R-HSA-419174

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Myosin-10, MYH10_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHA-mediated growth cone collapse (Homo sapiens)
        
        Activated ROCK phosphorylates MRLCs (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH10 [cytosol] (Homo sapiens)
        
        p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH10 [cytosol] (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - Sema4D in semaphorin signaling (Homo sapiens)
        
        Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
        
        Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH10 [cytosol] (Homo sapiens)
        
        p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH10 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P35580 MYH10

Gene Names

MYH10

Chain

chain:1-1976

Reference Genes

BioGPS Gene:4628 MYH10

COSMIC (genes):MYH10 MYH10

CTD Gene:4628 MYH10

dbSNP Gene:4628 MYH10

ENSEMBL:ENSG00000133026 MYH10

HGNC:7568 MYH10

KEGG:hsa:4628 MYH10

Monarch:4628 MYH10

NCBI Gene:4628 MYH10

OMIM:160776 MYH10

UCSC:P35580 MYH10

Reference Transcript

Other Identifiers

11736044_a_at

11736045_a_at

11754984_s_at

16840982

212372_PM_at

212372_at

213067_PM_at

213067_at

2523267

32838_at

3744458

3744460

3744462

3744464

3744465

3744466

3744467

3744468

3744469

3744470

3744471

3744472

3744473

3744474

3744475

3744476

3744477

3744478

3744479

3744480

3744481

3744482

3744483

3744484

3744485

3744486

3744487

3744490

3744491

3744492

3744493

3744494

3744495

3744497

3744498

3744501

3744503

3744504

3744505

3744506

3744507

3744508

3744509

3744510

3744511

3744512

3744513

3744514

3744518

3744519

3744520

3744521

3744522

3744523

3744524

3744525

3744526

3744527

3744528

3744529

3744530

3744531

3744532

3744533

3744534

3744536

3744537

3744538

3744546

3744548

3744549

3744550

3744551

3744552

3744553

3744558

3744565

3744568

3744569

3744573

3744582

40900_at

4628

68976_at

68979_g_at

8012475

8012518

A_24_P256764

A_24_P34168

A_33_P3235004

GE58791

GO:0000146

GO:0000166

GO:0000281

GO:0000910

GO:0001618

GO:0001701

GO:0001725

GO:0001764

GO:0001778

GO:0003279

GO:0003723

GO:0003774

GO:0003779

GO:0005515

GO:0005516

GO:0005524

GO:0005634

GO:0005737

GO:0005819

GO:0005829

GO:0005886

GO:0005903

GO:0005938

GO:0006887

GO:0006930

GO:0007097

GO:0007155

GO:0007409

GO:0007411

GO:0007420

GO:0007507

GO:0007512

GO:0008092

GO:0008360

GO:0009898

GO:0009986

GO:0016020

GO:0016192

GO:0016459

GO:0016460

GO:0016528

GO:0021592

GO:0021670

GO:0021678

GO:0021680

GO:0030027

GO:0030036

GO:0030048

GO:0030239

GO:0030424

GO:0030426

GO:0030496

GO:0031032

GO:0031175

GO:0031594

GO:0032154

GO:0032982

GO:0035613

GO:0035904

GO:0042641

GO:0042995

GO:0043005

GO:0043025

GO:0043197

GO:0043226

GO:0043531

GO:0046718

GO:0048027

GO:0048856

GO:0048870

GO:0050714

GO:0050877

GO:0050885

GO:0051015

GO:0055003

GO:0055015

GO:0060038

GO:0060041

GO:0060976

GO:0061024

GO:0070062

GO:0097513

GO:0098871

GO:0098974

GO:0098978

GO:0099512

GO:0140657

HMNXSV003055640

Hs.182919.0.A1_3p_at

Hs.296842.0.S1_3p_at

ILMN_1815154

M69181_at

PH_hs_0023429

S67247_s_at

TC17001118.hg

TC17001119.hg

TC17002479.hg

U34301_at

U34301_r_at

Participates

as a member of

Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)

Inferred To

MYO1 [cytosol] (Saccharomyces cerevisiae)

myo2 [cytosol] (Schizosaccharomyces pombe)

MYH10 [cytosol] (Bos taurus)

MYH10 [cytosol] (Gallus gallus)

Myh10 [cytosol] (Mus musculus)

mhcA [cytosol] (Dictyostelium discoideum)

Cross References

RefSeq

NP_001243024.1, XP_016880169.1, XP_016880171.1, XP_016880170.1, NP_001242941.1, NP_005955.3

OpenTargets

ENSG00000133026

ENSEMBL

ENST00000269243, ENST00000360416, ENST00000379980, ENSG00000133026, ENSP00000369315, ENST00000686654, ENSP00000509091, ENST00000688902, ENST00000687178, ENSP00000509748, ENST00000693441, ENSP00000353590, ENSP00000508862, ENSP00000509241, ENSP00000269243

HPA

ENSG00000133026-MYH10

GeneCards

MYH10

PRO

P35580

Pharos - Targets

P35580

GlyGen

P35580

PDB

4PD3

Interactors (4)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.615	21
UniProt:Q14164 IKBKE	5	IKBKE [cytosol] (R-HSA-450225) p-S172-IKBKE [cytosol] (R-HSA-450278) K63polyUb-K30,K401-IKBKE [cytosol] (R-HSA-9730436) p-S172-IKBKE [nucleoplasm] (R-HSA-4755521) monoSUMO1-K231-p-S172-IKBKE [nucleoplasm] (R-HSA-4755535)	0.589	2
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4
UniProt:P61981 YWHAG	1	YWHAG [cytosol] (R-HSA-380312)	0.519	2

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