Reactome | MYH14 [cytosol]

MYH14 [cytosol]

Stable Identifier

R-HSA-419176

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Myosin-14, MYH14_HUMAN

Locations in the PathwayBrowser

Expand all

Developmental Biology (Homo sapiens)

- Nervous system development (Homo sapiens)
  - Axon guidance (Homo sapiens)
    - EPH-Ephrin signaling (Homo sapiens)
      - EPHA-mediated growth cone collapse (Homo sapiens)
        
        Activated ROCK phosphorylates MRLCs (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH14 [cytosol] (Homo sapiens)
        
        p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH14 [cytosol] (Homo sapiens)
    - Semaphorin interactions (Homo sapiens)
      - Sema4D in semaphorin signaling (Homo sapiens)
        
        Sema4D induced cell migration and growth-cone collapse (Homo sapiens)
        
        Myosin regulatory light chain phosphorylation by ROCK (Homo sapiens)
        
        Smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH14 [cytosol] (Homo sapiens)
        
        p-T19,S20-MRLC-smooth muscle/non-muscle myosin II [cytosol] (Homo sapiens)
        
        Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)
        
        MYH14 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q7Z406 MYH14

Gene Names

MYH14, KIAA2034, FP17425

Chain

initiator methionine:, chain:2-1995

Reference Genes

BioGPS Gene:79784 MYH14

COSMIC (genes):MYH14 MYH14

CTD Gene:79784 MYH14

dbSNP Gene:79784 MYH14

ENSEMBL:ENSG00000105357 MYH14

HGNC:23212 MYH14

KEGG:hsa:79784 MYH14

Monarch:79784 MYH14

NCBI Gene:79784 MYH14

OMIM:608568 MYH14

UCSC:Q7Z406 MYH14

Reference Transcript

Other Identifiers

11751956_a_at

11755632_a_at

16864427

217545_PM_at

217545_at

217660_PM_at

217660_at

219946_PM_x_at

219946_x_at

226988_PM_s_at

226988_s_at

232977_PM_x_at

232977_x_at

234290_PM_x_at

234290_x_at

3839208

3839210

3839211

3839212

3839213

3839214

3839215

3839216

3839218

3839219

3839220

3839221

3839222

3839223

3839224

3839225

3839226

3839227

3839228

3839229

3839230

3839231

3839232

3839234

3839235

3839236

3839237

3839238

3839239

3839240

3839242

3839243

3839244

3839245

3839246

3839247

3839248

3839249

3839250

3839252

3839253

3839254

3839255

3839256

3839258

3839259

3839260

3839261

3839265

3839266

3839267

3839268

3839269

3839270

3839271

3839272

3839273

59370_at

79784

8030582

A_14_P108627

A_14_P109937

A_24_P323545

GE63330

GO:0000146

GO:0001725

GO:0003009

GO:0003012

GO:0003774

GO:0003779

GO:0005515

GO:0005516

GO:0005524

GO:0005737

GO:0005829

GO:0005903

GO:0007005

GO:0007010

GO:0007519

GO:0007605

GO:0008092

GO:0008360

GO:0016020

GO:0016459

GO:0016460

GO:0019228

GO:0030048

GO:0030424

GO:0030426

GO:0031032

GO:0032982

GO:0042641

GO:0043226

GO:0048856

GO:0050877

GO:0051015

GO:0070062

GO:0071625

GO:0097513

GO:0099512

GO:0140657

HMNXSV003052240

Hs.250389.0.S1_3p_at

Hs.250389.0.S1_3p_x_at

Hs.287317.0.S1_3p_at

Hs.287317.0.S1_3p_x_at

ILMN_1804461

ILMN_2392370

PH_hs_0006324

TC19000755.hg

g13376043_3p_a_at

Participates

as a member of

Smooth muscle/non-muscle myosin 2 heavy chains [cytosol] (Homo sapiens)

Inferred To

ZIP1 [cytosol] (Saccharomyces cerevisiae)

Homologues of MYH14 [cytosol] (Caenorhabditis elegans)

Homologues of MYH14 [cytosol] (Saccharomyces cerevisiae)

Homologues of MYH14 [cytosol] (Schizosaccharomyces pombe)

MYH14 [cytosol] (Bos taurus)

MYH14 [cytosol] (Caenorhabditis elegans)

MYH14 [cytosol] (Dictyostelium discoideum)

MYH14 [cytosol] (Drosophila melanogaster)

MYH14 [cytosol] (Mus musculus)

MYH14 [cytosol] (Rattus norvegicus)

MYH14 [cytosol] (Saccharomyces cerevisiae)

MYH14 [cytosol] (Schizosaccharomyces pombe)

MYH14 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_006723449.1, XP_011525625.1, NP_079005.3, NP_001139281.1, NP_001070654.1

ENSEMBL

ENST00000596571, ENSP00000493594, ENST00000598205, ENSP00000366169, ENST00000642316, ENST00000425460, ENST00000376970, ENSP00000407879, ENSP00000472819, ENSP00000472543

OpenTargets

ENSG00000105357

HPA

ENSG00000105357-MYH14

PRO

Q7Z406

Pharos - Targets

Q7Z406

GlyGen

Q7Z406

Orphanet

MYH14

PDB

5I4E, 5JLH

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.615	20
UniProt:O15111 CHUK	4	CHUK [cytosol] (R-HSA-168104) p-S176,S180-CHUK [cytosol] (R-HSA-177667) p-T23-CHUK [cytosol] (R-HSA-198615) p-Y187,Y198-CHUK [cytosol] (R-HSA-9861501)	0.564	2
UniProt:P03372 ESR1	10	ESR1 [cytosol] (R-HSA-9020968) ESR1 [nucleoplasm] (R-HSA-446168) Me260-PalmS-ESR1 [plasma membrane] (R-HSA-9637788) PalmS-ESR1 [plasma membrane] (R-HSA-9021057) PalmS-ESR1 [cytosol] (R-HSA-9020974) Me260-ESR1 [cytosol] (R-HSA-9632177) p-S167-ESR1 [cytosol] (R-HSA-9841254) p-S167-ESR1 [nucleoplasm] (R-HSA-9841867) monoSUMO1-5K-ESR1 [nucleoplasm] (R-HSA-4090302) p-S118-ESR1 [nucleoplasm] (R-HSA-9024210)	0.527	2