Reactome | p-S20-MYL9 [cytosol]

p-S20-MYL9 [cytosol]

Stable Identifier

R-HSA-445798

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

Phosphorylated Myosin regulatory light polypeptide 9, MYL9_HUMAN, MYL9

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Locations in the PathwayBrowser

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Muscle contraction (Homo sapiens)

- Smooth Muscle Contraction (Homo sapiens)
  - ATP Hydrolysis By Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL9 [cytosol] (Homo sapiens)
    - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL9 [cytosol] (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL9 [cytosol] (Homo sapiens)
  - Calcium Binds Caldesmon (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL9 [cytosol] (Homo sapiens)
    - Inactive Myosin Actin Contractile Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL9 [cytosol] (Homo sapiens)
  - Myosin Binds ATP (Homo sapiens)
    - ATP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ATP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL9 [cytosol] (Homo sapiens)
    - p-S CALD1-Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL9 [cytosol] (Homo sapiens)
  - Phosphorylation of Smooth Muscle Myosin Light Chains (Homo sapiens)
    - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
      - p-S20-MYL9 [cytosol] (Homo sapiens)
  - Release Of ADP From Myosin (Homo sapiens)
    - ADP:Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - ADP Bound Smooth Muscle Myosin Complex [cytosol] (Homo sapiens)
        
        Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL9 [cytosol] (Homo sapiens)
    - Calcium Bound Myosin Actin Complex [plasma membrane] (Homo sapiens)
      - Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)
        
        p-S20-MYL9 [cytosol] (Homo sapiens)

External Reference Information

External Reference

UniProt:P24844 MYL9

Gene Names

MYL9, MLC2, MRLC1, MYRL2

Chain

initiator methionine:1, chain:2-172

Reference Genes

BioGPS Gene:10398 MYL9

COSMIC (genes):MYL9 MYL9

CTD Gene:10398 MYL9

dbSNP Gene:10398 MYL9

ENSEMBL:ENSG00000101335 MYL9

HGNC:15754 MYL9

KEGG:hsa:10398 MYL9

Monarch:10398 MYL9

NCBI Gene:10398 MYL9

OMIM:609905 MYL9

UCSC:P24844 MYL9

Reference Transcript

Participates

as a member of

Phosphorylated Smooth Muscle Myosin Light Chain [cytosol] (Homo sapiens)

Other forms of this molecule

p-T19-MYL9 [cytosol]

p-T19,S20-MYL9 [cytosol]

MYL9 [cytosol]

Inferred To

phospho-rlc1 [cytosol] (Schizosaccharomyces pombe)

Homologues of p-S20-MYL9 [cytosol] (Canis familiaris)

phospho-myl9 [cytosol] (Xenopus tropicalis)

phospho-myl9b [cytosol] (Danio rerio)

phospho-Myl9 [cytosol] (Mus musculus)

phospho-Myl9 [cytosol] (Rattus norvegicus)

phospho-MLC2 [cytosol] (Saccharomyces cerevisiae)

phospho-p-S20-MYL9 [cytosol] (Plasmodium falciparum)

phospho-MYL12B [cytosol] (Canis familiaris)

phospho-MYL9 [cytosol] (Bos taurus)

phospho-MYL9 [cytosol] (Canis familiaris)

phospho-MYL9 [cytosol] (Gallus gallus)

phospho-MYL9 [cytosol] (Sus scrofa)

phospho-mlcR [cytosol] (Dictyostelium discoideum)

Modified Residues

Name

O-phospho-L-serine at 20

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Cross References

RefSeq

NP_006088.2, NP_852667.1

ENSEMBL

ENSP00000279022, ENST00000346786, ENSP00000217313, ENSG00000101335, ENST00000279022

OpenTargets

ENSG00000101335

GeneCards

MYL9

HPA

ENSG00000101335-MYL9

PRO

P24844

Pharos - Targets

P24844

HMDB Protein

HMDBP07826

Interactors (3)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P35579 MYH9	3	MYH9 [cytosol] (R-HSA-419173) MYH9(2-1644)-ALK(1067-1620) fusion [cytosol] (R-HSA-9715280) MYH9(2-1644)-p-7Y-ALK(1067-1620) fusion [cytosol] (R-HSA-9715279)	0.547	2
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279)	0.527	16
UniProt:E9Q8Q6 CC141			0.463	2

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