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p-S207,T211-MAP2K6 [nucleoplasm]
Stable Identifier
R-HSA-450258
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
p-S207,T211-MKK6, mitogen-activated protein kinase kinase 6 (phosphorylated)
Icon
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Cellular Senescence (Homo sapiens)
Oxidative Stress Induced Senescence (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK5 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Gene expression (Transcription) (Homo sapiens)
RNA Polymerase II Transcription (Homo sapiens)
Generic Transcription Pathway (Homo sapiens)
Transcriptional Regulation by TP53 (Homo sapiens)
Regulation of TP53 Activity (Homo sapiens)
Regulation of TP53 Activity through Acetylation (Homo sapiens)
PI5P Regulates TP53 Acetylation (Homo sapiens)
MAP2K6 phosphorylates PIP4K2B (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
Signaling by Interleukins (Homo sapiens)
Interleukin-17 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Innate Immune System (Homo sapiens)
Toll-like Receptor Cascades (Homo sapiens)
Toll Like Receptor 10 (TLR10) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 2 (TLR2) Cascade (Homo sapiens)
Toll Like Receptor TLR1:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Toll Like Receptor TLR6:TLR2 Cascade (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 3 (TLR3) Cascade (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 4 (TLR4) Cascade (Homo sapiens)
MyD88-independent TLR4 cascade (Homo sapiens)
TRIF (TICAM1)-mediated TLR4 signaling (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
MyD88:MAL(TIRAP) cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 5 (TLR5) Cascade (Homo sapiens)
MyD88 cascade initiated on plasma membrane (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 7/8 (TLR7/8) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Toll Like Receptor 9 (TLR9) Cascade (Homo sapiens)
MyD88 dependent cascade initiated on endosome (Homo sapiens)
TRAF6 mediated induction of NFkB and MAP kinases upon TLR7/8 or 9 activation (Homo sapiens)
MAP kinase activation (Homo sapiens)
activated TAK1 mediates p38 MAPK activation (Homo sapiens)
Activated human MKK3/MKK6 phosphorylates p38 MAPK complexed with MAPKAPK2 or MAPKAPK3 (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Phosphorylated MKK3/MKK6 migrates to nucleus (Homo sapiens)
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:P52564 MAP2K6
Gene Names
MAP2K6, MEK6, MKK6, PRKMK6, SKK3
Chain
chain:1-334
Reference Genes
COSMIC (genes):MAP2K6 MAP2K6
dbSNP Gene:5608 MAP2K6
ENSEMBL:ENSG00000108984 MAP2K6
Participates
as a member of
p-S189,T193-MAP2K3, p-S207,T211-MAP2K6 [nucleoplasm] (Homo sapiens)
Other forms of this molecule
MAP2K6 [cytosol]
p-S207,T211-MAP2K6 [cytosol]
Inferred To
phospho-lic [nucleoplasm]
(Drosophila melanogaster)
phospho-sek-5 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-S207,T211-MAP2K6 [nucleoplasm]
(Bos taurus)
phospho-p-S207,T211-MAP2K6 [nucleoplasm]
(Caenorhabditis elegans)
phospho-p-S207,T211-MAP2K6 [nucleoplasm]
(Danio rerio)
phospho-p-S207,T211-MAP2K6 [nucleoplasm]
(Dictyostelium discoideum)
phospho-p-S207,T211-MAP2K6 [nucleoplasm]
(Gallus gallus)
phospho-p-S207,T211-MAP2K6 [nucleoplasm]
(Mus musculus)
phospho-p-S207,T211-MAP2K6 [nucleoplasm]
(Rattus norvegicus)
phospho-p-S207,T211-MAP2K6 [nucleoplasm]
(Sus scrofa)
phospho-p-S207,T211-MAP2K6 [nucleoplasm]
(Xenopus tropicalis)
Homologues of p-S207,T211-MAP2K6 [nucleoplasm]
(Caenorhabditis elegans)
phospho-sek-4 [nucleoplasm]
(Caenorhabditis elegans)
phospho-MAP2K6 [nucleoplasm]
(Canis familiaris)
Modified Residues
Name
O-phospho-L-serine at 207
Coordinate
207
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-threonine at 211
Coordinate
211
PsiMod Name
O-phospho-L-threonine [MOD:00047]
PsiMod Definition
A protein modification that effectively converts an L-threonine residue to O-phospho-L-threonine.
Interactors (8)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:Q16236 NFE2L2
13
p-S40-NFE2L2 [nucleoplasm]
(R-HSA-9715109)
p-S,T-NFE2L2 [nucleoplasm]
(R-HSA-9715110)
p-S40-NFE2L2 [cytosol]
(R-HSA-8932290)
p-S,T-NFE2L2 [cytosol]
(R-HSA-8932311)
NFE2L2 [cytosol]
(R-HSA-201566)
p-S,T-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760033)
p-S40-18 AcK-NFE2L2 [nucleoplasm]
(R-HSA-9760018)
ub-NFE2L2 [cytosol]
(R-HSA-9758077)
ub-p-S335, S338,T-NFE2L2 [nucleoplasm]
(R-HSA-9762055)
ub-p-S40, S335, S338- NFE2L2 [nucleoplasm]
(R-HSA-9762058)
p-S344, S347,T-NFE2L2 [nucleoplasm]
(R-HSA-9762048)
p-S40, S344, S347- NFE2L2 [nucleoplasm]
(R-HSA-9762050)
p-S,T,S558-NFE2L2 [nucleoplasm]
(R-HSA-9795736)
0.625
5
UniProt:P46734 MAP2K3
3
MAP2K3 [cytosol]
(R-HSA-168051)
p-S218,T222-MAP2K3 [cytosol]
(R-HSA-167955)
p-S218,T222-MAP2K3 [nucleoplasm]
(R-HSA-450229)
0.615
3
UniProt:Q16539 MAPK14
7
MAPK14 [ficolin-1-rich granule lumen]
(R-HSA-6803280)
MAPK14 [extracellular region]
(R-HSA-6806453)
MAPK14 [secretory granule lumen]
(R-HSA-6803300)
MAPK14 [nucleoplasm]
(R-HSA-446223)
MAPK14 [cytosol]
(R-HSA-428933)
p-T180,Y182-MAPK14 [cytosol]
(R-HSA-428935)
p-T180,Y182-MAPK14 [nucleoplasm]
(R-HSA-446227)
0.564
3
UniProt:O76024 WFS1
3
WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956747)
p-WFS1 [endoplasmic reticulum lumen]
(R-HSA-8956998)
WFS1 [endoplasmic reticulum membrane]
(R-HSA-535474)
0.556
3
UniProt:Q9NRD5 PICK1
2
PICK1 [plasma membrane]
(R-HSA-416989)
PICK1 [endocytic vesicle membrane]
(R-HSA-417017)
0.556
3
UniProt:P24522 GADD45A
1
GADD45A [nucleoplasm]
(R-HSA-3215139)
0.519
2
UniProt:Q9Y6R4 M3K4
0.519
2
UniProt:Q5S007 LRRK2
1
LRRK2 [cytosol]
(R-HSA-5661173)
0.463
4
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