Reactome | AMPD2 [cytosol]

AMPD2 [cytosol]

Stable Identifier

R-HSA-49927

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

AMP deaminase isoform L, AMP deaminase 2, AMP deaminase 2 (EC 3.5.4.6) (AMP deaminase isoform L)

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
7287721	Platelet AMP deaminase. Purification and kinetic studies. Holmsen, H	J Biol Chem	1981
	The Metabolic and Molecular Bases of Inherited Disease, 8th ed Beaudet, AL, Scriver, CR, Sly, WS, Valle, D		2001

External Reference Information

External Reference

UniProt:Q01433 AMPD2

Gene Names

AMPD2

Chain

chain:1-825

Reference Genes

BioGPS Gene:271 AMPD2

COSMIC (genes):AMPD2 AMPD2

CTD Gene:271 AMPD2

dbSNP Gene:271 AMPD2

ENSEMBL:ENSG00000116337 AMPD2

ENSEMBL_homo_sapiens_GENE:ENSG00000116337.20 AMPD2

HGNC:469 AMPD2

KEGG Gene (Homo sapiens):271 AMPD2

Monarch:271 AMPD2

NCBI Gene:271 AMPD2

OMIM:102771 AMPD2

UCSC:Q01433 AMPD2

Reference Transcript

Other Identifiers

11724224_a_at

11730829_a_at

11730830_x_at

11745744_a_at

16668288

212360_PM_at

212360_at

2350881

2350882

2350889

2350892

2350893

2350894

2350895

2350896

2350897

2350898

2350899

2350900

2350901

2350902

2350903

2350904

2350905

2350907

2350908

2350909

2350910

2350911

2350912

2350913

2350914

271

38417_at

7903719

A_23_P201596

GE58134

GO:0003824

GO:0003876

GO:0005515

GO:0005829

GO:0006188

GO:0009117

GO:0009168

GO:0016787

GO:0019239

GO:0032264

GO:0042802

GO:0046033

GO:0046872

GO:0052652

GO:0055086

GO:0097009

GO:1901135

HMNXSV003024033

HMNXSV003057632

Hs.82927.0.S2_3p_at

ILMN_1786899

M91029_cds2_at

PH_hs_0004744

TC01000950.hg

Participates

as a component of

AMPD2 tetramer [cytosol] (Homo sapiens)

Inferred To

AMPdeam [cytosol] (Drosophila melanogaster)

ampd-1 [cytosol] (Caenorhabditis elegans)

AMPD2 [cytosol] (Bos taurus)

AMPD2 [cytosol] (Canis familiaris)

AMPD2 [cytosol] (Dictyostelium discoideum)

AMPD2 [cytosol] (Gallus gallus)

AMPD2 [cytosol] (Mus musculus)

AMPD2 [cytosol] (Plasmodium falciparum)

AMPD2 [cytosol] (Rattus norvegicus)

AMPD2 [cytosol] (Saccharomyces cerevisiae)

AMPD2 [cytosol] (Schizosaccharomyces pombe)

AMPD2 [cytosol] (Sus scrofa)

Cross References

RefSeq

NP_631895.1, NP_004028.3, NP_001244290.1, NP_981949.1, NP_001295099.1, NP_001244289.1

OpenTargets

ENSG00000116337

ZINC - Substances

AMPD2_HUMAN

ZINC target

Q01433

PRO

Q01433

PDB

8HU6, 8HUB, 4NO5, 4NO3

GeneCards

Q01433

HPA

ENSG00000116337-AMPD2

Ensembl

ENST00000531734, ENST00000531203, ENSP00000433739, ENST00000528454, ENST00000342115, ENSG00000116337, ENSP00000431975, ENSP00000345498, ENSP00000437164

Pharos - Targets

Q01433

ZINC - Predictions - Purchasable

AMPD2_HUMAN

Orphanet

22560

HMDB Protein

HMDBP00599

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P31946 YWHAB	1	YWHAB [cytosol] (R-HSA-48888)	0.527	2