Reactome | HYOU1 [endoplasmic reticulum lumen]

HYOU1 [endoplasmic reticulum lumen]

Stable Identifier

R-HSA-535542

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

endoplasmic reticulum lumen

Synonyms

Hypoxia up-regulated protein 1, HYOU1_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q9Y4L1 HYOU1

Gene Names

HYOU1, GRP170, ORP150, ORP150

Chain

signal peptide:1-32, chain:33-999

Reference Genes

BioGPS Gene:10525 HYOU1

COSMIC (genes):HYOU1 HYOU1

CTD Gene:10525 HYOU1

dbSNP Gene:10525 HYOU1

ENSEMBL:ENSG00000149428 HYOU1

ENSEMBL_homo_sapiens_GENE:ENSG00000149428.21 HYOU1

ENSEMBL_homo_sapiens_GENE:ENSG00000280682.3 HYOU1

HGNC:16931 HYOU1

KEGG Gene (Homo sapiens):10525 HYOU1

Monarch:10525 HYOU1

NCBI Gene:10525 HYOU1

OMIM:601746 HYOU1

UCSC:Q9Y4L1 HYOU1

Reference Transcript

Other Identifiers

10525

11716005_a_at

11716006_a_at

11748624_a_at

11748625_x_at

11749688_a_at

11749689_x_at

11750616_a_at

11752033_x_at

11756961_a_at

16745186

200825_PM_s_at

200825_s_at

33863_at

3394124

3394125

3394126

3394127

3394128

3394129

3394130

3394131

3394132

3394133

3394135

3394138

3394140

3394142

3394143

3394144

3394145

3394146

3394147

3394149

3394150

3394151

3394152

3394153

3394154

3394155

3394159

3394160

3394161

3394162

3394164

3394165

3394167

3394168

3394169

3394171

3394172

3394173

3394174

7952145

A_23_P75647

GE59322

GO:0000166

GO:0000774

GO:0002931

GO:0005515

GO:0005524

GO:0005576

GO:0005615

GO:0005783

GO:0005788

GO:0005790

GO:0005925

GO:0006457

GO:0006888

GO:0012501

GO:0016020

GO:0016192

GO:0023052

GO:0031410

GO:0034663

GO:0034976

GO:0043066

GO:0043226

GO:0044183

GO:0051082

GO:0051087

GO:0070062

GO:0071456

GO:0071682

GO:0098772

GO:0140657

GO:0140662

GO:1903298

GO:1903382

HMNXSV003013820

ILMN_1673649

ILMN_2141790

PH_hs_0014249

TC11002361.hg

U65785_at

g13699861_3p_a_at

Participates

as an output of

Expression of HYOU1 (Homo sapiens)

Other forms of this molecule

HYOU1 [extracellular region]

HYOU1 [endocytic vesicle lumen]

Cross References

RefSeq

XP_016872586.1, NP_001124463.1, NP_006380.1, XP_016872585.1

OpenTargets

ENSG00000149428

HPA

ENSG00000149428-HYOU1

GeneCards

Q9Y4L1

Ensembl

ENSG00000149428, ENST00000530473, ENSG00000280682, ENST00000614711, ENSP00000480248, ENST00000534233, ENSP00000486825, ENSP00000431874, ENST00000617285, ENST00000630669, ENSP00000462951, ENSP00000480150

PRO

Q9Y4L1

Pharos - Targets

Q9Y4L1

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P11021 HSPA5	6	HSPA5 [extracellular region] (R-HSA-351322) HSPA5 [endoplasmic reticulum lumen] (R-HSA-387190) HSPA5 [endoplasmic reticulum membrane] (R-HSA-351315) HSPA5 [cytosol] (R-HSA-5252115) HSPA5 [nucleoplasm] (R-HSA-5252042) HSPA5 [lumenal side of endoplasmic reticulum membrane] (R-HSA-985498)	0.669	3
UniProt:P0DTC8 8	2	8 [extracellular region] (R-COV-9755410) 8 [endoplasmic reticulum lumen] (R-COV-9727283)	0.643	3
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.615	16
UniProt:P06213 INSR	6	p-6Y-INSR(763-1382) [endosome membrane] (R-HSA-141719) INSR(763-1382) [endosome membrane] (R-HSA-141722) INSR(28-758) [endosome membrane] (R-HSA-141718) INSR(763-1382) [plasma membrane] (R-HSA-74669) p-6Y-INSR(763-1382) [plasma membrane] (R-HSA-74670) INSR(28-758) [plasma membrane] (R-HSA-74668)	0.569	3
UniProt:P27824 CANX	2	CANX [lumenal side of endoplasmic reticulum membrane] (R-HSA-983091) CANX [endoplasmic reticulum lumen] (R-HSA-195906)	0.569	4
UniProt:P02452 COL1A1	20	3x4Hyp-3Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023648) 3x4Hyp-GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023667) GlcGalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023604) GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022999) 3x4Hyp-3Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023559) 3x4Hyp-GalHyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2023582) COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1650777) 3x4Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985659) 3x4Hyp-3Hyp-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022446) 3x4Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022951) 3x4Hyp-3Hyp-5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-2022954) 5Hyl-COL1A1(23-1464) [endoplasmic reticulum lumen] (R-HSA-1985663) Lysyl-pyrrolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396137) Lysyl-pyrrolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396440) Lysyl-pyrrolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396471) Lysyl-pyridinolyl 5-hydroxylysyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396464) Lysyl-pyridinolyl 4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396068) Lysyl-pyridinolyl 3,4-Hyp 5-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396388) Dehydrolysinonorlysyl 4-hydroxyprolyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396315) Dehydrolysinonorlysyl 4-Hyp 5-Gal-Hyl collagen alpha-1(I) chain [extracellular region] (R-HSA-2396441)	0.558	3
UniProt:P00533 EGFR	20	p-6Y-EGFR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869138) p-5Y-EGFRvIII [plasma membrane] (R-HSA-1248649) EGFRvIII [plasma membrane] (R-HSA-1214162) p-6Y-EGFR E746_A750del;T790M [plasma membrane] (R-HSA-1182985) p-6Y-EGFR L858R;T790M [plasma membrane] (R-HSA-1182984) p-6Y-EGFR A767_V769dup [plasma membrane] (R-HSA-1996343) p-6Y-EGFR N771_H773dup [plasma membrane] (R-HSA-1996342) p-6Y-EGFR K739_I744dup [plasma membrane] (R-HSA-1996346) p-6Y-EGFR D770_N771insNPG [plasma membrane] (R-HSA-1996335) p-6Y-EGFR E746_A750del [plasma membrane] (R-HSA-1181214) p-6Y-EGFR L858R [plasma membrane] (R-HSA-1173211) p-6Y-EGFR G719S [plasma membrane] (R-HSA-1169417) p-6Y-EGFR L747_P753delinsS [plasma membrane] (R-HSA-1228038) p-6Y-EGFR L747_A750delinsP [plasma membrane] (R-HSA-1228044) p-6Y-EGFR L747_T751del [plasma membrane] (R-HSA-1228041) p-6Y-EGFR L747_S752del [plasma membrane] (R-HSA-1228040) p-6Y-EGFR L747_T751delinsP [plasma membrane] (R-HSA-1228042) p-6Y-EGFR E746_T751delinsA [plasma membrane] (R-HSA-1228037) p-6Y-EGFR E746_S752delinsV [plasma membrane] (R-HSA-1228039) p-6Y-EGFR L861Q [plasma membrane] (R-HSA-1177541)	0.527	2

Cite Us!