Reactome | TUFM [mitochondrial matrix]

TUFM [mitochondrial matrix]

Stable Identifier

R-HSA-5389846

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

Elongation factor Tu, mitochondrial, EFTU_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:P49411 TUFM

Gene Names

TUFM

Chain

transit peptide:1-46, chain:47-455

Reference Genes

BioGPS Gene:7284 TUFM

COSMIC (genes):TUFM TUFM

CTD Gene:7284 TUFM

dbSNP Gene:7284 TUFM

ENSEMBL:ENSG00000178952 TUFM

ENSEMBL_homo_sapiens_GENE:ENSG00000178952.11 TUFM

HGNC:12420 TUFM

KEGG Gene (Homo sapiens):7284 TUFM

Monarch:7284 TUFM

NCBI Gene:7284 TUFM

OMIM:602389 TUFM

UCSC:P49411 TUFM

Reference Transcript

Other Identifiers

11715468_at

16825410

201113_PM_at

201113_at

238190_PM_at

238190_at

2890089

3686729

3686730

3686732

3686733

3686735

3686736

3686738

3686739

3686740

3686741

3686742

3686743

3686744

3750178

3750189

3750199

3750203

39867_at

7284

8000603

92041_at

GE58809

GO:0000166

GO:0003723

GO:0003746

GO:0003824

GO:0003924

GO:0005515

GO:0005525

GO:0005576

GO:0005615

GO:0005739

GO:0005741

GO:0006412

GO:0006414

GO:0016020

GO:0016787

GO:0042645

GO:0043226

GO:0045182

GO:0045202

GO:0045471

GO:0070062

GO:0070125

GO:0140053

HMNXSV003035927

HMNXSV003036684

Hs.171379.0.A1_3p_at

ILMN_1738369

PH_hs_0001135

PH_hs_0035348

S75463_at

TC16000994.hg

TC16001829.hg

g4507732_3p_at

Participates

as a component of

Other forms of this molecule

TUFM [mitochondrial outer membrane]

Cross References

RefSeq

XP_016879108.1, NP_003312.3

OpenTargets

ENSG00000178952

GeneCards

P49411

HPA

ENSG00000178952-TUFM

Ensembl

ENST00000313511, ENSP00000322439, ENSG00000178952

PRO

P49411

Pharos - Targets

P49411

Orphanet

20154

HMDB Protein

HMDBP08372

PDB

7A5G, 7O9K

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:Q8IZU0 FAM9B			0.666	4
UniProt:P03427 PB2			0.599	9
UniProt:Q15041 AR6P1			0.556	3
UniProt:Q96DZ9 CKLF5			0.556	3
UniProt:Q8IVP5 FUNDC1	4	p-S17-FUNDC1 [mitochondrial outer membrane] (R-HSA-8948140) p-S13,Y18-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934915) FUNDC1 [mitochondrial outer membrane] (R-HSA-8934922) p-S13-FUNDC1 [mitochondrial outer membrane] (R-HSA-8934910)	0.556	3
UniProt:Q96RQ3 MCCC1	9	L437P Btn-MCCC1 [mitochondrial matrix] (R-HSA-9908666) V694* Btn-MCCC1 [mitochondrial matrix] (R-HSA-9908683) D532H Btn-MCCC1 [mitochondrial matrix] (R-HSA-9908652) M325R Btn-MCCC1 [mitochondrial matrix] (R-HSA-9908669) I460M Btn-MCCC1 [mitochondrial matrix] (R-HSA-9908657) R385S Btn-MCCC1 [mitochondrial matrix] (R-HSA-9908676) Btn-MCCC1 [cytosol] (R-HSA-3323154) MCCC1 [cytosol] (R-HSA-3323164) Btn-MCCC1 [mitochondrial matrix] (R-HSA-70748)	0.527	2
UniProt:Q9UK85 DKKL1			0.527	3
UniProt:O95789 ZMYM6			0.527	2
UniProt:P10636-8 MAPT	3	p-S199,S202,S262,S396,S404,S409,T181,T231-MAPT-8 [cytosol] (R-HSA-9836400) p-S262,S356,S396-MAPT-8 [cytosol] (R-HSA-9619521) MAPT-8 [cytosol] (R-HSA-9619519)	0.527	4
UniProt:Q5S007 LRRK2	1	LRRK2 [cytosol] (R-HSA-5661173)	0.527	3
UniProt:Q01523 DEFA5	5	DEFA5(1-94) [Golgi lumen] (R-HSA-1467267) DEFA5(20-94) [Golgi lumen] (R-HSA-1467208) DEFA5(20-94) [secretory granule lumen] (R-HSA-1471358) DEFA5(20-94) [extracellular region] (R-HSA-1471344) DEFA5(?-94) [extracellular region] (R-HSA-1462017)	0.527	2
UniProt:P46199 MTIF2	1	MTIF2 [mitochondrial matrix] (R-HSA-5368271)	0.527	2
UniProt:Q8N307 MUC20	19	Core 8 (MUC20) [Golgi lumen] (R-HSA-1462329) Core 2S (MUC20) [Golgi lumen] (R-HSA-6786382) Core 5 (MUC20) [Golgi lumen] (R-HSA-1462128) Core 4 (MUC20) [Golgi lumen] (R-HSA-1462266) Core 3 (MUC20) [Golgi lumen] (R-HSA-1462344) Core 7 (MUC20) [Golgi lumen] (R-HSA-1462236) extended Core 6 (MUC20) [Golgi lumen] (R-HSA-1967016) Core 6 (MUC20) [Golgi lumen] (R-HSA-1462247) MUC20 [Golgi lumen] (R-HSA-913634) Disialyl T-antigen (MUC20) [Golgi lumen] (R-HSA-1463482) Sialyl T-antigen (MUC20) [Golgi lumen] (R-HSA-1463469) Sialyl-2,3 T-antigen (MUC20) [Golgi lumen] (R-HSA-1463479) T-antigen (MUC20) [Golgi lumen] (R-HSA-1462188) Sialyl Tn antigen (MUC20) [Golgi lumen] (R-HSA-1463558) GalNAc-MUC20 [Golgi lumen] (R-HSA-1463443) Core 2a (MUC20) [Golgi lumen] (R-HSA-6784267) Core 2 (MUC20) [Golgi lumen] (R-HSA-1462330) GalNAc-MUC20 [plasma membrane] (R-HSA-8858516) MUC20 [plasma membrane] (R-HSA-8851833)	0.527	2
UniProt:Q86UT6 NLRX1	2	K63polyUb-NLRX1 [cytosol] (R-HSA-9749510) NLRX1 [mitochondrial outer membrane] (R-HSA-936551)	0.499	2
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.483	12
UniProt:A0A096LP01 SIM26			0.462	2
UniProt:Q00005 2ABB			0.462	2

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