Reactome | K48-polyUb-p-7S-p100 [cytosol]

K48-polyUb-p-7S-p100 [cytosol]

Stable Identifier

R-HSA-5607636

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K48-polyUb-p-7S-NFKB2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q00653 NFKB2

Gene Names

NFKB2, LYT10

Chain

chain:1-900, chain:1-454

Reference Genes

BioGPS Gene:4791 NFKB2

COSMIC (genes):NFKB2 NFKB2

CTD Gene:4791 NFKB2

dbSNP Gene:4791 NFKB2

ENSEMBL:ENSG00000077150.20 NFKB2

HGNC:7795 NFKB2

KEGG Gene (Homo sapiens):4791 NFKB2

Monarch:4791 NFKB2

NCBI Gene:4791 NFKB2

OMIM:164012 NFKB2

UCSC:Q00653 NFKB2

Reference Transcript

Other Identifiers

0005390100

11725153_a_at

16708623

207535_3p_s_at

207535_PM_s_at

207535_s_at

209636_3p_at

209636_PM_at

209636_at

3261644

3261645

3261646

3261647

3261648

3261649

3261651

3261653

3261654

3261655

3261656

3261657

3261658

3261659

3261661

3261662

3261664

3261665

3261667

3261668

3261670

3261671

3261673

3261674

3261675

3261677

3261678

3261679

3261680

3261681

40362_at

4791

535_s_at

544_at

545_g_at

7930074

A_23_P202156

GE81163

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0002268

GO:0002376

GO:0002467

GO:0003677

GO:0003700

GO:0005515

GO:0005622

GO:0005634

GO:0005654

GO:0005694

GO:0005737

GO:0005829

GO:0006351

GO:0006355

GO:0006357

GO:0007165

GO:0010605

GO:0023052

GO:0030154

GO:0030198

GO:0032991

GO:0033257

GO:0038061

GO:0043226

GO:0045944

GO:0048511

GO:0048536

GO:0048856

GO:0071159

GO:1990837

HMNXSV003045072

ILMN_1799062

ILMN_2247868

ILMN_2390859

PH_hs_0027671

S76638_at

TC10000753.hg

U20816_s_at

g12803988_3p_at

g12803988_3p_x_at

Participates

as a component of

K48-polyUb-p-7S-p100:RELB [cytosol] (Homo sapiens)

Other forms of this molecule

monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]

NFKB2(1-900) [cytosol]

p-7S-p100 [cytosol]

NFKB2(1-454) [cytosol]

NFKB2(1-454) [nucleoplasm]

Inferred To

phospho-Nfkb2 [cytosol] (Mus musculus)

phospho-Nfkb2 [cytosol] (Rattus norvegicus)

phospho-nfkb2 [cytosol] (Xenopus tropicalis)

phospho-Dif [cytosol] (Drosophila melanogaster)

phospho-NFKB2 [cytosol] (Bos taurus)

phospho-NFKB2 [cytosol] (Sus scrofa)

Homologues of K48-polyUb-p-7S-p100 [cytosol] (Drosophila melanogaster)

phospho-K48-polyUb-p-7S-p100 [cytosol] (Canis familiaris)

phospho-K48-polyUb-p-7S-p100 [cytosol] (Danio rerio)

phospho-dl [cytosol] (Drosophila melanogaster)

phospho-Rel [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-serine at 99

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 108

Coordinate

108

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 115

Coordinate

115

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 123

Coordinate

123

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 866

Coordinate

866

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 870

Coordinate

870

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 872

Coordinate

872

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at 855

Coordinate

855

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

RefSeq

NP_001309863.1, NP_001248332.1, NP_001070962.1, NP_001275653.1, NP_001309864.1, NP_002493.3

OpenTargets

ENSG00000077150

HPA

ENSG00000077150-NFKB2

GeneCards

Q00653

Ensembl

ENSP00000499294, ENST00000652277, ENST00000661543, ENSP00000358983, ENSG00000077150, ENST00000189444, ENST00000369966, ENSP00000189444, ENSP00000410256, ENSP00000498308, ENST00000428099

PRO

Q00653

Pharos - Targets

Q00653

Orphanet

22523

PDB

3DO7, 7VUQ, 7W7L, 7CLI, 1A3Q, 5ZMC, 7VUP, 2D96, 4OT9

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19838 NFKB1	8	NFKB1(1-968) [specific granule lumen] (R-HSA-6799557) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-968) [cytosol] (R-HSA-451607) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) 3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619)	0.772	8
UniProt:Q99558 MAP3K14	5	p-T559-MAP3K14 [cytosol] (R-HSA-5668531) Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525)	0.643	4
UniProt:P41279 MAP3K8	3	p-S400-MAP3K8 [cytosol] (R-HSA-389738) MAP3K8 [cytosol] (R-HSA-389388) p-S400,T290-MAP3K8 [cytosol] (R-HSA-5684259)	0.564	3
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.564	3
UniProt:Q01201 RELB	2	RELB [nucleoplasm] (R-HSA-5607656) RELB [cytosol] (R-HSA-5607652)	0.564	3
UniProt:P25963 NFKBIA	11	PolyUb-NFKBIA [cytosol] (R-HSA-6782960) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA [nucleoplasm] (R-HSA-4656929) NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol] (R-HSA-5607659) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-9711050) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805)	0.564	3
UniProt:Q9NWT6 HIF1AN	1	HIF1AN [cytosol] (R-HSA-1234154)	0.527	2