Reactome | K48-polyUb-p-7S-p100 [cytosol]

K48-polyUb-p-7S-p100 [cytosol]

Stable Identifier

R-HSA-5607636

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

K48-polyUb-p-7S-NFKB2

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q00653 NFKB2

Gene Names

NFKB2, LYT10

Chain

chain:1-900, chain:1-454

Reference Genes

BioGPS Gene:4791 NFKB2

COSMIC (genes):NFKB2 NFKB2

CTD Gene:4791 NFKB2

dbSNP Gene:4791 NFKB2

ENSEMBL:ENSG00000077150 NFKB2

HGNC:7795 NFKB2

KEGG:hsa:4791 NFKB2

Monarch:4791 NFKB2

NCBI Gene:4791 NFKB2

OMIM:164012 NFKB2

UCSC:Q00653 NFKB2

Reference Transcript

Other Identifiers

11725153_a_at

16708623

207535_3p_s_at

207535_PM_s_at

207535_s_at

209636_3p_at

209636_PM_at

209636_at

3261644

3261645

3261646

3261647

3261648

3261649

3261650

3261651

3261652

3261653

3261654

3261655

3261656

3261657

3261658

3261659

3261660

3261661

3261662

3261663

3261664

3261665

3261666

3261667

3261668

3261669

3261670

3261671

3261672

3261673

3261674

3261675

3261676

3261677

3261678

3261679

3261680

3261681

3261682

40362_at

4791

535_s_at

544_at

545_g_at

7930074

A_14_P114090

A_23_P202156

GE81163

GO:0000785

GO:0000978

GO:0000981

GO:0001228

GO:0002268

GO:0002376

GO:0002467

GO:0003677

GO:0003700

GO:0005515

GO:0005634

GO:0005654

GO:0005737

GO:0005829

GO:0006355

GO:0006954

GO:0007165

GO:0007249

GO:0010468

GO:0030154

GO:0030198

GO:0032496

GO:0033257

GO:0034097

GO:0038061

GO:0043226

GO:0045087

GO:0045944

GO:0048511

GO:0048536

GO:0048856

GO:0098542

GO:0140110

GO:1990837

HMNXSV003045072

ILMN_1799062

ILMN_2247868

ILMN_2390859

PH_hs_0027671

S76638_at

TC10000753.hg

U20816_s_at

g12803988_3p_at

g12803988_3p_x_at

Participates

as a component of

K48-polyUb-p-7S-p100:RELB [cytosol] (Homo sapiens)

Other forms of this molecule

NFKB2(1-454) [nucleoplasm]

NFKB2(1-454) [cytosol]

p-7S-p100 [cytosol]

NFKB2(1-900) [cytosol]

monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]

Inferred To

phospho-Nfkb2 [cytosol] (Mus musculus)

phospho-Nfkb2 [cytosol] (Rattus norvegicus)

phospho-NFKB2 [cytosol] (Bos taurus)

phospho-NFKB2 [cytosol] (Canis familiaris)

phospho-NFKB2 [cytosol] (Sus scrofa)

phospho-Rel [cytosol] (Drosophila melanogaster)

Modified Residues

Name

O-phospho-L-serine at 99

Coordinate

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 108

Coordinate

108

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 115

Coordinate

115

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 123

Coordinate

123

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 866

Coordinate

866

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 870

Coordinate

870

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

O-phospho-L-serine at 872

Coordinate

872

PsiMod Name

O-phospho-L-serine [MOD:00046]

PsiMod Definition

A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.

Name

ubiquitinylated lysine (K48polyUb [cytosol]) at 855

Coordinate

855

Modification

K48polyUb [cytosol]

PsiMod Name

ubiquitinylated lysine [MOD:01148]

PsiMod Definition

A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.

Cross References

Guide to Pharmacology - Targets

3282

ENSEMBL

ENST00000661543, ENST00000369966, ENST00000428099, ENST00000189444, ENSG00000077150, ENSP00000358983, ENSP00000498308, ENSP00000189444, ENST00000652277, ENSP00000410256, ENSP00000499294

OpenTargets

ENSG00000077150

GeneCards

NFKB2

HPA

ENSG00000077150-NFKB2

PRO

Q00653

Pharos - Targets

Q00653

Orphanet

NFKB2

GlyGen

Q00653

PDB

8G8Q, 8G8S, 3DO7, 7VUP, 7CLI, 7VUQ, 7W7L, 4OT9, 5ZMC, 2D96, 1A3Q

Interactors (12)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P19838 NFKB1	8	3xUb-p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451619) p-S927,S932-NFKB1(1-968) [cytosol] (R-HSA-451611) NFKB1(1-968) [cytosol] (R-HSA-451607) NFKB1(1-433) [nucleoplasm] (R-HSA-177655) NFKB1(1-433) [cytosol] (R-HSA-168168) NFKB1(1-968) [secretory granule lumen] (R-HSA-6801004) NFKB1(1-968) [extracellular region] (R-HSA-6806304) NFKB1(1-968) [specific granule lumen] (R-HSA-6799557)	0.823	10
UniProt:Q01201 RELB	2	RELB [nucleoplasm] (R-HSA-5607656) RELB [cytosol] (R-HSA-5607652)	0.744	6
UniProt:Q04864 REL	2	REL [cytosol] (R-HSA-1168579) REL [nucleoplasm] (R-HSA-1168585)	0.744	6
UniProt:P25963 NFKBIA	9	NFKBIA [cytosol] (R-HSA-168151) p-S32,S36-NFKBIA [cytosol] (R-HSA-177677) Ub-K21,22-p-S32,S36-NFKBIA [cytosol] (R-HSA-1168581) NFKBIA [nucleoplasm] (R-HSA-4656929) monoSUMO1-K21-NFKBIA [nucleoplasm] (R-HSA-4656935) NFKBIA S32I [cytosol] (R-HSA-5228846) NFKBIA F2_M37del [cytosol] (R-HSA-9630119) NFKBIA M37K [cytosol] (R-HSA-5228805) PolyUb-NFKBIA [cytosol] (R-HSA-6782960)	0.744	5
UniProt:Q99558 MAP3K14	5	Active NIK [cytosol] (R-HSA-5607646) MAP3K14 [cytosol] (R-HSA-168189) p-MAP3K14 [cytosol] (R-HSA-168187) K48polyUb-NIK [cytosol] (R-HSA-5668525) p-T559-MAP3K14 [cytosol] (R-HSA-5668531)	0.643	4
UniProt:Q9NWT6 HIF1AN	1	HIF1AN [cytosol] (R-HSA-1234154)	0.643	3
UniProt:Q15653 NFKBIB	3	p-S19,S23-Ub-NFKBIB [cytosol] (R-HSA-1168571) p-S19,S23-NFKBIB [cytosol] (R-HSA-177670) NFKBIB [cytosol] (R-HSA-168132)	0.564	4
UniProt:P41279 MAP3K8	3	p-S400,T290-MAP3K8 [cytosol] (R-HSA-5684259) MAP3K8 [cytosol] (R-HSA-389388) p-S400-MAP3K8 [cytosol] (R-HSA-389738)	0.564	3
UniProt:Q9H4E7 DEF6	1	DEF6 [cytosol] (R-HSA-9691487)	0.527	3
UniProt:Q9ULW8 PADI3	2	PADI3 [cytosol] (R-HSA-1183173) PADI3 [nucleoplasm] (R-HSA-6793444)	0.527	3
UniProt:Q8NI38 IKBD			0.527	3
UniProt:P09917 ALOX5	6	p-S272-ALOX5 [nuclear envelope] (R-HSA-2318765) ALOX5 [cytosol] (R-HSA-429010) ALOX5 [ficolin-1-rich granule lumen] (R-HSA-6801302) ALOX5 [extracellular region] (R-HSA-6806468) ALOX5 [secretory granule lumen] (R-HSA-6801306) p-S272-ALOX5 [cytosol] (R-HSA-265276)	0.527	2