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K48-polyUb-p-7S-p100 [cytosol]
Stable Identifier
R-HSA-5607636
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
K48-polyUb-p-7S-NFKB2
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
TNFR2 non-canonical NF-kB pathway (Homo sapiens)
NIK-->noncanonical NF-kB signaling (Homo sapiens)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
K48-polyUb-p-7S-p100:RELB [cytosol] (Homo sapiens)
K48-polyUb-p-7S-p100 [cytosol] (Homo sapiens)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
K48-polyUb-p-7S-p100:RELB [cytosol] (Homo sapiens)
K48-polyUb-p-7S-p100 [cytosol] (Homo sapiens)
Innate Immune System (Homo sapiens)
C-type lectin receptors (CLRs) (Homo sapiens)
CLEC7A (Dectin-1) signaling (Homo sapiens)
Dectin-1 mediated noncanonical NF-kB signaling (Homo sapiens)
26S proteasome processes p-7S-p100:RELB to form p52:RELB (Homo sapiens)
K48-polyUb-p-7S-p100:RELB [cytosol] (Homo sapiens)
K48-polyUb-p-7S-p100 [cytosol] (Homo sapiens)
SCF-beta-TRCP ubiquitinates p-7S-p100:RELB in active NIK:p-176,S180-IKKA dimer:p-7S-p100:SCF-beta-TRCP (Homo sapiens)
K48-polyUb-p-7S-p100:RELB [cytosol] (Homo sapiens)
K48-polyUb-p-7S-p100 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q00653 NFKB2
Gene Names
NFKB2, LYT10
Chain
chain:1-900, chain:1-454
Reference Genes
BioGPS Gene:4791 NFKB2
COSMIC (genes):NFKB2 NFKB2
CTD Gene:4791 NFKB2
dbSNP Gene:4791 NFKB2
ENSEMBL:ENSG00000077150.20 NFKB2
HGNC:7795 NFKB2
KEGG Gene (Homo sapiens):4791 NFKB2
Monarch:4791 NFKB2
NCBI Gene:4791 NFKB2
OMIM:164012 NFKB2
UCSC:Q00653 NFKB2
Reference Transcript
RefSeq:NM_001261403.2 NFKB2
RefSeq:NM_001077494.3 NFKB2
RefSeq:NM_001288724.1 NFKB2
RefSeq:NM_001322935.1 NFKB2
RefSeq:NM_001322934.1 NFKB2
RefSeq:NM_002502.5 NFKB2
Other Identifiers
0005390100
11725153_a_at
16708623
207535_3p_s_at
207535_PM_s_at
207535_s_at
209636_3p_at
209636_PM_at
209636_at
3261644
3261645
3261646
3261647
3261648
3261649
3261651
3261653
3261654
3261655
3261656
3261657
3261658
3261659
3261661
3261662
3261664
3261665
3261667
3261668
3261670
3261671
3261673
3261674
3261675
3261677
3261678
3261679
3261680
3261681
40362_at
4791
535_s_at
544_at
545_g_at
7930074
A_23_P202156
GE81163
GO:0000785
GO:0000978
GO:0000981
GO:0001228
GO:0002268
GO:0002376
GO:0002467
GO:0003677
GO:0003700
GO:0005515
GO:0005622
GO:0005634
GO:0005654
GO:0005694
GO:0005737
GO:0005829
GO:0006351
GO:0006355
GO:0006357
GO:0007165
GO:0010605
GO:0023052
GO:0030154
GO:0030198
GO:0032991
GO:0033257
GO:0038061
GO:0043226
GO:0045944
GO:0048511
GO:0048536
GO:0048856
GO:0071159
GO:1990837
HMNXSV003045072
ILMN_1799062
ILMN_2247868
ILMN_2390859
PH_hs_0027671
S76638_at
TC10000753.hg
U20816_s_at
g12803988_3p_at
g12803988_3p_x_at
Participates
as a component of
K48-polyUb-p-7S-p100:RELB [cytosol] (Homo sapiens)
Other forms of this molecule
monoSUMO1-K90,K298,K689,K863-NFKB2(1-900) [cytosol]
NFKB2(1-900) [cytosol]
p-7S-p100 [cytosol]
NFKB2(1-454) [cytosol]
NFKB2(1-454) [nucleoplasm]
Inferred To
phospho-Nfkb2 [cytosol]
(Mus musculus)
phospho-Nfkb2 [cytosol]
(Rattus norvegicus)
phospho-nfkb2 [cytosol]
(Xenopus tropicalis)
phospho-Dif [cytosol]
(Drosophila melanogaster)
phospho-NFKB2 [cytosol]
(Bos taurus)
phospho-NFKB2 [cytosol]
(Sus scrofa)
Homologues of K48-polyUb-p-7S-p100 [cytosol]
(Drosophila melanogaster)
phospho-K48-polyUb-p-7S-p100 [cytosol]
(Canis familiaris)
phospho-K48-polyUb-p-7S-p100 [cytosol]
(Danio rerio)
phospho-dl [cytosol]
(Drosophila melanogaster)
phospho-Rel [cytosol]
(Drosophila melanogaster)
Modified Residues
Name
O-phospho-L-serine at 99
Coordinate
99
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 108
Coordinate
108
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 115
Coordinate
115
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 123
Coordinate
123
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 866
Coordinate
866
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 870
Coordinate
870
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
O-phospho-L-serine at 872
Coordinate
872
PsiMod Name
O-phospho-L-serine [MOD:00046]
PsiMod Definition
A protein modification that effectively converts an L-serine residue to O-phospho-L-serine.
Name
ubiquitinylated lysine (K48polyUb [cytosol]) at 855
Coordinate
855
Modification
K48polyUb [cytosol]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
NP_001309863.1
,
NP_001248332.1
,
NP_001070962.1
,
NP_001275653.1
,
NP_001309864.1
,
NP_002493.3
OpenTargets
ENSG00000077150
HPA
ENSG00000077150-NFKB2
GeneCards
Q00653
Ensembl
ENSP00000499294
,
ENST00000652277
,
ENST00000661543
,
ENSP00000358983
,
ENSG00000077150
,
ENST00000189444
,
ENST00000369966
,
ENSP00000189444
,
ENSP00000410256
,
ENSP00000498308
,
ENST00000428099
PRO
Q00653
Pharos - Targets
Q00653
Orphanet
22523
PDB
3DO7
,
7VUQ
,
7W7L
,
7CLI
,
1A3Q
,
5ZMC
,
7VUP
,
2D96
,
4OT9
Interactors (7)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P19838 NFKB1
8
NFKB1(1-968) [specific granule lumen]
(R-HSA-6799557)
NFKB1(1-968) [extracellular region]
(R-HSA-6806304)
NFKB1(1-968) [secretory granule lumen]
(R-HSA-6801004)
NFKB1(1-433) [cytosol]
(R-HSA-168168)
NFKB1(1-433) [nucleoplasm]
(R-HSA-177655)
NFKB1(1-968) [cytosol]
(R-HSA-451607)
p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451611)
3xUb-p-S927,S932-NFKB1(1-968) [cytosol]
(R-HSA-451619)
0.772
8
UniProt:Q99558 MAP3K14
5
p-T559-MAP3K14 [cytosol]
(R-HSA-5668531)
Active NIK [cytosol]
(R-HSA-5607646)
MAP3K14 [cytosol]
(R-HSA-168189)
p-MAP3K14 [cytosol]
(R-HSA-168187)
K48polyUb-NIK [cytosol]
(R-HSA-5668525)
0.643
4
UniProt:P41279 MAP3K8
3
p-S400-MAP3K8 [cytosol]
(R-HSA-389738)
MAP3K8 [cytosol]
(R-HSA-389388)
p-S400,T290-MAP3K8 [cytosol]
(R-HSA-5684259)
0.564
3
UniProt:Q04864 REL
2
REL [cytosol]
(R-HSA-1168579)
REL [nucleoplasm]
(R-HSA-1168585)
0.564
3
UniProt:Q01201 RELB
2
RELB [nucleoplasm]
(R-HSA-5607656)
RELB [cytosol]
(R-HSA-5607652)
0.564
3
UniProt:P25963 NFKBIA
11
PolyUb-NFKBIA [cytosol]
(R-HSA-6782960)
monoSUMO1-K21-NFKBIA [nucleoplasm]
(R-HSA-4656935)
NFKBIA [nucleoplasm]
(R-HSA-4656929)
NFKBIA [cytosol]
(R-HSA-168151)
p-S32,S36-NFKBIA [cytosol]
(R-HSA-177677)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-1168581)
K48PolyUb-K21,22-p-S32,S36-IkBA [cytosol]
(R-HSA-5607659)
Ub-K21,22-p-S32,S36-NFKBIA [cytosol]
(R-HSA-9711050)
NFKBIA S32I [cytosol]
(R-HSA-5228846)
NFKBIA F2_M37del [cytosol]
(R-HSA-9630119)
NFKBIA M37K [cytosol]
(R-HSA-5228805)
0.564
3
UniProt:Q9NWT6 HIF1AN
1
HIF1AN [cytosol]
(R-HSA-1234154)
0.527
2
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