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K48PolyUb-KDM4A [nucleoplasm]
Stable Identifier
R-HSA-5683049
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
nucleoplasm
Synonyms
K48PolyUb-JMJD2A
Locations in the PathwayBrowser
Expand all
DNA Repair (Homo sapiens)
DNA Double-Strand Break Repair (Homo sapiens)
DNA Double Strand Break Response (Homo sapiens)
Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks (Homo sapiens)
RNF8 and RNF168 ubiquitinate KDM4A,B (Homo sapiens)
K48PolyUb-KDM4A,B [nucleoplasm] (Homo sapiens)
K48PolyUb-KDM4A [nucleoplasm] (Homo sapiens)
External Reference Information
External Reference
UniProt:O75164 KDM4A
Gene Names
KDM4A, JHDM3A, JMJD2, JMJD2A, KIAA0677
Chain
initiator methionine:, chain:2-1064
Reference Genes
BioGPS Gene:9682 KDM4A
COSMIC (genes):KDM4A KDM4A
CTD Gene:9682 KDM4A
dbSNP Gene:9682 KDM4A
ENSEMBL:ENSG00000066135 KDM4A
ENSEMBL_homo_sapiens_GENE:ENSG00000066135.13 KDM4A
HGNC:22978 KDM4A
KEGG Gene (Homo sapiens):9682 KDM4A
Monarch:9682 KDM4A
NCBI Gene:9682 KDM4A
OMIM:609764 KDM4A
UCSC:O75164 KDM4A
Reference Transcript
RefSeq:XM_005271354.3 KDM4A
RefSeq:NM_014663.2 KDM4A
RefSeq:XM_005271355.3 KDM4A
Other Identifiers
11726729_at
11726730_a_at
16663665
203204_PM_s_at
203204_s_at
203205_PM_at
203205_at
2333430
2333431
2333432
2333433
2333434
2333436
2333439
2333442
2333445
2333448
2333449
2333451
2333452
2333453
2333454
2333457
2333458
2333460
2333461
2333462
2333463
2333464
2333465
2333471
2333472
2333473
2333474
2333475
2333476
2333477
2333478
32073_at
7900833
9682
A_14_P132839
A_23_P74446
A_33_P3420655
GE53384
GO:0000785
GO:0001650
GO:0003012
GO:0003824
GO:0005515
GO:0005634
GO:0005654
GO:0005694
GO:0005721
GO:0005730
GO:0005829
GO:0006325
GO:0006338
GO:0006351
GO:0006355
GO:0006914
GO:0008270
GO:0010468
GO:0010507
GO:0010628
GO:0010629
GO:0012501
GO:0014898
GO:0016491
GO:0030154
GO:0030263
GO:0031625
GO:0031667
GO:0032452
GO:0032454
GO:0035064
GO:0036211
GO:0042393
GO:0043226
GO:0043229
GO:0045666
GO:0045892
GO:0046872
GO:0048712
GO:0048856
GO:0051213
GO:0051864
GO:0140096
GO:0140681
GO:0140684
HMNXSV003046382
ILMN_1736650
PH_hs_0009402
TC01000549.hg
Z70219_at
g12803466_3p_a_at
g7662245_3p_at
Participates
as a member of
K48PolyUb-KDM4A,B [nucleoplasm] (Homo sapiens)
Other forms of this molecule
KDM4A [nucleoplasm]
Inferred To
Kdm4a [nucleoplasm]
(Rattus norvegicus)
RPH1 [nucleoplasm]
(Saccharomyces cerevisiae)
GIS1 [nucleoplasm]
(Saccharomyces cerevisiae)
K48PolyUb-KDM4A [nucleoplasm]
(Mus musculus)
KDM4A [nucleoplasm]
(Bos taurus)
KDM4A [nucleoplasm]
(Canis familiaris)
KDM4A [nucleoplasm]
(Gallus gallus)
KDM4A [nucleoplasm]
(Sus scrofa)
Homologues of K48PolyUb-KDM4A [nucleoplasm]
(Saccharomyces cerevisiae)
Modified Residues
Name
ubiquitinylated lysine (K48polyUb [nucleoplasm]) at unknown position
Modification
K48polyUb [nucleoplasm]
PsiMod Name
ubiquitinylated lysine [MOD:01148]
PsiMod Definition
A protein modification that effectively crosslinks the N6-amino of a peptidyl lysine with the carboxyl-terminal glycine of a ubiquitin.
Cross References
RefSeq
XP_005271412.1
,
XP_005271411.1
,
NP_055478.2
Guide to Pharmacology - Targets
2675
OpenTargets
ENSG00000066135
HPA
ENSG00000066135-KDM4A
ZINC - Substances
KDM4A_HUMAN
GeneCards
O75164
ZINC target
O75164
Ensembl
ENST00000372396
,
ENSP00000361473
,
ENSG00000066135
PRO
O75164
Pharos - Targets
O75164
ZINC - Predictions - Purchasable
KDM4A_HUMAN
PDB
5F39
,
6H4R
,
6H4Q
,
2OS2
,
2GP3
,
2YBS
,
2GP5
,
5VGI
,
2P5B
,
3U4S
,
2Q8E
,
7D4A
,
5FYI
,
2YBP
,
5F3I
,
6H4O
,
5FYH
,
5F37
,
5F2W
,
2Q8D
,
5F32
,
2Q8C
,
2YBK
,
2OX0
,
6H4V
,
4BIS
,
5F3G
,
6H4U
,
5FYC
,
5ANQ
,
2WWJ
,
5F3E
,
7EQV
,
2QQS
,
5A7W
,
5FY8
,
5D6W
,
6H4T
,
6H4S
,
5A80
,
2PXJ
,
3PDQ
,
5D6X
,
4URA
,
2QQR
,
5FPV
,
5F3C
,
4V2W
,
2OQ7
,
6H4Y
,
2VD7
,
2GF7
,
6CG2
,
6CG1
,
5VAR
,
4AI9
,
5VMP
,
5TVR
,
5A7O
,
4GD4
,
5A7P
,
6H8P
,
6H4P
,
6H4X
,
5LY2
,
5F5I
,
6H4W
,
2OT7
,
5LY1
,
5A7N
,
2OQ6
,
5F2S
,
5FWE
,
6HGT
,
8WD3
,
2GFA
,
3NJY
,
5D6Y
,
3RVH
,
5A7Q
,
6G5X
,
6G5W
,
4V2V
,
5TVS
,
5A7S
Interactors (5)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P62805 H4C1
17
polySUMO3-HIST1H4 [nucleoplasm]
(R-HSA-4570531)
monoSUMO1-HIST1H4 [nucleoplasm]
(R-HSA-4570518)
4xAcK-HIST1H4A [nucleoplasm]
(R-HSA-427390)
AcK5,12-HIST1H4A [nucleoplasm]
(R-HSA-212078)
AcK13-HIST1H4 [nucleoplasm]
(R-HSA-4568744)
Me2aR4-HIST1H4 [nucleoplasm]
(R-HSA-5229015)
Me2sR4-HIST1H4 [nucleoplasm]
(R-HSA-4754243)
MeR4-HIST1H4 [nucleoplasm]
(R-HSA-4754240)
Me3K21-HIST1H4 [nucleoplasm]
(R-HSA-5651656)
HIST1H4A [extracellular region]
(R-HSA-977569)
AcK17-HIST1H4 [nucleoplasm]
(R-HSA-427469)
AcK6-HIST1H4 [nucleoplasm]
(R-HSA-4568748)
AcK9-HIST1H4 [nucleoplasm]
(R-HSA-4568758)
MeK21-HIST1H4 [nucleoplasm]
(R-HSA-5423110)
AcK-HIST1H4 [nucleoplasm]
(R-HSA-3451124)
Me2K21-HIST1H4 [nucleoplasm]
(R-HSA-5651652)
HIST1H4 [nucleoplasm]
(R-HSA-181902)
0.743
7
UniProt:Q16695 H3-4
3
HIST3H3 [nucleoplasm]
(R-HSA-181914)
Me3K5-HIST3H3 [nucleoplasm]
(R-HSA-2245188)
Me2K5-HIST3H3 [nucleoplasm]
(R-HSA-2245186)
0.618
6
UniProt:Q15831 STK11
2
STK11 [cytosol]
(R-HSA-380954)
STK11 [nucleoplasm]
(R-HSA-164119)
0.527
3
UniProt:P33993 MCM7
1
MCM7 [nucleoplasm]
(R-HSA-68555)
0.462
3
UniProt:P25205 MCM3
1
MCM3 [nucleoplasm]
(R-HSA-68546)
0.462
3
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