Reactome | NDUFAF5 [mitochondrial inner membrane]

NDUFAF5 [mitochondrial inner membrane]

Stable Identifier

R-HSA-5689127

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial inner membrane

Synonyms

NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 5, NDUF5_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q5TEU4 NDUFAF5

Gene Names

NDUFAF5, C20orf7

Chain

transit peptide:1-36, chain:37-345

Reference Genes

BioGPS Gene:79133 NDUFAF5

COSMIC (genes):NDUFAF5 NDUFAF5

CTD Gene:79133 NDUFAF5

dbSNP Gene:79133 NDUFAF5

ENSEMBL:ENSG00000101247 NDUFAF5

ENSEMBL_homo_sapiens_GENE:ENSG00000101247.18 NDUFAF5

HGNC:15899 NDUFAF5

KEGG Gene (Homo sapiens):79133 NDUFAF5

Monarch:79133 NDUFAF5

NCBI Gene:79133 NDUFAF5

OMIM:612360 NDUFAF5

UCSC:Q5TEU4 NDUFAF5

Reference Transcript

Other Identifiers

11754489_a_at

16911525

219524_PM_s_at

219524_s_at

222894_PM_x_at

222894_x_at

227160_3p_s_at

227160_PM_s_at

227160_s_at

3877222

3877223

3877224

3877227

3877228

3877229

3877230

3877231

3877232

3877236

3877247

3877249

3877250

3877251

3877252

3877253

3877254

3877256

62140_at

62141_g_at

79133

8061019

GE88168

GO:0003674

GO:0003824

GO:0005515

GO:0005739

GO:0005743

GO:0007005

GO:0008168

GO:0008757

GO:0016020

GO:0016491

GO:0016740

GO:0030961

GO:0032259

GO:0032981

GO:0036211

GO:0043226

GO:0065003

GO:0099617

HMNXSV003057621

Hs.44296.0.S1_3p_s_at

ILMN_2262543

ILMN_2350607

PH_hs_0033263

TC20001111.hg

g13129143_3p_s_at

Participates

as an input of

Intermediate 2 binds MT-ND1:NDUFAF5:NDUFAF6 to form a 315kDa subcomplex (Homo sapiens)

as an output of

The MCIA complex, NDUFAF2-7 all dissociate from the 980kDa complex, resulting in Complex I (Homo sapiens)

as a component of

315kDa subcomplex [mitochondrial inner membrane] (Homo sapiens)

Inferred To

ndufaf5 [mitochondrial inner membrane] (Danio rerio)

ndufaf5 [mitochondrial inner membrane] (Xenopus tropicalis)

Ndufaf5 [mitochondrial inner membrane] (Mus musculus)

Ndufaf5 [mitochondrial inner membrane] (Rattus norvegicus)

Dmel\CG8067 [mitochondrial inner membrane] (Drosophila melanogaster)

NDUFAF5 [mitochondrial inner membrane] (Bos taurus)

NDUFAF5 [mitochondrial inner membrane] (Caenorhabditis elegans)

NDUFAF5 [mitochondrial inner membrane] (Canis familiaris)

NDUFAF5 [mitochondrial inner membrane] (Gallus gallus)

NDUFAF5 [mitochondrial inner membrane] (Sus scrofa)

Cross References

RefSeq

NP_001034464.1, NP_077025.2

OpenTargets

ENSG00000101247

HPA

ENSG00000101247-NDUFAF5

GeneCards

Q5TEU4

Ensembl

ENST00000378106, ENSP00000367346, ENST00000463598, ENSG00000101247, ENSP00000420497

PRO

Q5TEU4

Pharos - Targets

Q5TEU4

Orphanet

17842

Interactors (17)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:A1L188 NDUFAF8	1	NDUFAF8 [mitochondrion] (R-HSA-9906776)	0.748	11
UniProt:O75251 NDUFS7	1	NDUFS7 [mitochondrial matrix] (R-HSA-6788521)	0.643	5
UniProt:Q9BVS5 TRMT61B	1	TRMT61B [mitochondrial matrix] (R-HSA-6787512)	0.615	4
UniProt:P69905 HBA1	4	CO-H+-HBA1 [cytosol] (R-HSA-1237026) HBA1 [cytosol] (R-HSA-1008268) HBA1 [endocytic vesicle lumen] (R-HSA-2230966) HBA1 [extracellular region] (R-HSA-2168862)	0.527	2
UniProt:Q7Z2W9 MRPL21	1	MRPL21 [mitochondrial inner membrane] (R-HSA-5368231)	0.527	2
UniProt:Q8TAA5 GRPEL2	1	GRPEL2 [mitochondrial inner membrane] (R-HSA-1252076)	0.527	2
UniProt:O95299 NDUFA10	1	NDUFA10 [mitochondrial inner membrane] (R-HSA-163937)	0.527	2
UniProt:Q53GT1 KLHL22	1	KLHL22 [cytosol] (R-HSA-8863210)	0.527	3
UniProt:Q5BKU9 OXLD1			0.527	2
UniProt:Q96DV4 MRPL38	1	MRPL38 [mitochondrial inner membrane] (R-HSA-5368202)	0.527	2
UniProt:O60361 NME2P1	1	NME2P1 [cytosol] (R-HSA-6806876)	0.527	2
UniProt:P01185 AVP	10	AVP(20-28) [extracellular region] (R-HSA-388474) AVP(20-28) [cytosol] (R-HSA-879509) AVP E47del [extracellular region] (R-HSA-5621396) AVP P7L [extracellular region] (R-HSA-5621460) AVP C67* [extracellular region] (R-HSA-5621431) AVP V67A [extracellular region] (R-HSA-5621446) AVP A1T [extracellular region] (R-HSA-5621473) AVP Y2H [extracellular region] (R-HSA-5621449) AVP G23R [extracellular region] (R-HSA-5621464) AVP(20-28) [clathrin-coated endocytic vesicle membrane] (R-HSA-8869075)	0.527	2
UniProt:P68871 HBB	8	CO-H+-HBB [cytosol] (R-HSA-1237013) HBB [ficolin-1-rich granule lumen] (R-HSA-6801015) HBB [tertiary granule lumen] (R-HSA-6800191) HBB [endocytic vesicle lumen] (R-HSA-2230936) HBB [extracellular region] (R-HSA-2168872) HBB [late endosome lumen] (R-HSA-9631108) HBB [cytosol] (R-HSA-1008196) HBB [lysosomal lumen] (R-HSA-9625193)	0.527	2
UniProt:O75489 NDUFS3	2	NDUFS3 [mitochondrial matrix] (R-HSA-163927) NDUFS3 [cytosol] (R-HSA-9714751)	0.527	2
UniProt:P14324 FDPS	1	FDPS [cytosol] (R-HSA-981566)	0.527	2
UniProt:O43543 XRCC2	1	XRCC2 [nucleoplasm] (R-HSA-5685302)	0.527	2
UniProt:P01160 NPPA	5	NPPA(124-151) [extracellular region] (R-HSA-5578799) NPPA(1-151) [extracellular region] (R-HSA-976950) NPPA(1-25) [extracellular region] (R-HSA-5578791) NPPA(56-123) [extracellular region] (R-HSA-5578797) NPPA(26-55) [extracellular region] (R-HSA-5578794)	0.527	2

Cite Us!