Reactome | IDH3B [mitochondrial matrix]

IDH3B [mitochondrial matrix]

Stable Identifier

R-HSA-70963

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial matrix

Synonyms

isocitrate dehydrogenase 3 (NAD+) beta, Isocitrate dehydrogenase (NAD) subunit beta, mitochondrial precursor, Isocitric dehydrogenase, NAD+-specific ICDH

Locations in the PathwayBrowser

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Literature References

PubMed ID	Title	Journal	Year
20435888	Each conserved active site tyr in the three subunits of human isocitrate dehydrogenase has a different function Dange, M, Colman, RF	J Biol Chem	2010

External Reference Information

External Reference

UniProt:O43837 IDH3B

Gene Names

IDH3B

Chain

transit peptide:1-34, chain:35-385

Reference Genes

BioGPS Gene:3420 IDH3B

COSMIC (genes):IDH3B IDH3B

CTD Gene:3420 IDH3B

dbSNP Gene:3420 IDH3B

ENSEMBL:ENSG00000101365 IDH3B

HGNC:5385 IDH3B

KEGG:hsa:3420 IDH3B

Monarch:3420 IDH3B

NCBI Gene:3420 IDH3B

OMIM:604526 IDH3B

UCSC:O43837 IDH3B

Reference Transcript

Other Identifiers

11730186_a_at

11730187_x_at

11733576_a_at

11744207_a_at

11745811_a_at

11745812_x_at

16916574

201509_PM_at

201509_at

210014_PM_x_at

210014_x_at

210418_PM_s_at

210418_s_at

3420

3895076

3895077

3895078

3895079

3895080

3895081

3895082

3895083

3895084

3895085

3895086

3895087

3895088

3895089

3895090

3895091

3895092

3895093

3895094

3895095

3895096

3895097

3895099

3895100

3895102

3895103

3895106

3895107

40110_at

40111_g_at

40112_at

8064522

A_19_P00809916

A_23_P166068

A_23_P502196

A_33_P3261084

A_33_P3358069

GE81693

GO:0000287

GO:0003824

GO:0004449

GO:0005515

GO:0005634

GO:0005739

GO:0005759

GO:0006099

GO:0006102

GO:0009055

GO:0016491

GO:0016616

GO:0043226

GO:0045242

GO:0051287

HMNXSV003013485

HMNXSV003037279

ILMN_1721669

ILMN_1810400

ILMN_2373632

PH_hs_0020528

PH_hs_0035995

TC20000563.hg

TC20001384.hg

g4103445_3p_a_at

Participates

as a component of

IDH3 complex [mitochondrial matrix] (Homo sapiens)

Inferred To

Idh3B [mitochondrial matrix] (Rattus norvegicus)

Idh3b [mitochondrial matrix] (Drosophila melanogaster)

Idh3b [mitochondrial matrix] (Mus musculus)

IDH3B [mitochondrial matrix] (Bos taurus)

IDH3B [mitochondrial matrix] (Caenorhabditis elegans)

IDH3B [mitochondrial matrix] (Canis familiaris)

IDH3B [mitochondrial matrix] (Dictyostelium discoideum)

IDH3B [mitochondrial matrix] (Saccharomyces cerevisiae)

IDH3B [mitochondrial matrix] (Schizosaccharomyces pombe)

IDH3B [mitochondrial matrix] (Sus scrofa)

Cross References

RefSeq

NP_001317692.1, NP_777280.1, NP_008830.2

ENSEMBL

ENST00000380843, ENSG00000101365, ENST00000380851, ENSP00000370223, ENSP00000370232

OpenTargets

ENSG00000101365

GeneCards

IDH3B

HPA

ENSG00000101365-IDH3B

PRO

O43837

Pharos - Targets

O43837

GlyGen

O43837

Orphanet

IDH3B

HMDB Protein

HMDBP00897

PDB

7CE3, 6KDY, 8GS5, 8GRU, 8GRB, 6KDF, 6KDE, 8GRD, 6KE3

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	6

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