Reactome | UBE2S [nucleoplasm]

UBE2S [nucleoplasm]

Stable Identifier

R-HSA-8852051

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin-conjugating enzyme E2 S ecNumber evidence="6 7 8"2.3.2.23/ecNumber, UBE2S_HUMAN

Locations in the PathwayBrowser

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Disease (Homo sapiens)

- Diseases of mitotic cell cycle (Homo sapiens)
  - Aberrant regulation of mitotic cell cycle due to RB1 defects (Homo sapiens)
    - Aberrant regulation of mitotic exit in cancer due to RB1 defects (Homo sapiens)
      - Defective RB1 does not form a complex with SKP2 and FZR1 (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        UBE2S [nucleoplasm] (Homo sapiens)

Gene expression (Transcription) (Homo sapiens)

- RNA Polymerase II Transcription (Homo sapiens)
  - Generic Transcription Pathway (Homo sapiens)
    - Transcriptional Regulation by VENTX (Homo sapiens)
      - Regulation of IL6 transcription (Homo sapiens)
        
        Cdh1:phospho-APC/C complex [nucleoplasm] (Homo sapiens)
        
        phosphorylated anaphase promoting complex (APC/C) [nucleoplasm] (Homo sapiens)
        
        UBE2S [nucleoplasm] (Homo sapiens)

Metabolism of proteins (Homo sapiens)

- Post-translational protein modification (Homo sapiens)
  - Protein ubiquitination (Homo sapiens)
    - Synthesis of active ubiquitin: roles of E1 and E2 enzymes (Homo sapiens)
      - UBA1 conjugates ubiquitin to nuclear E2 enzymes (Homo sapiens)
        
        E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)
        
        UBE2S [nucleoplasm] (Homo sapiens)

External Reference Information

External Reference

UniProt:Q16763 UBE2S

Gene Names

UBE2S, E2EPF, OK/SW-cl.73

Chain

chain:1-222

Reference Genes

BioGPS Gene:27338 UBE2S

COSMIC (genes):UBE2S UBE2S

CTD Gene:27338 UBE2S

dbSNP Gene:27338 UBE2S

ENSEMBL:ENSG00000108106 UBE2S

HGNC:17895 UBE2S

KEGG:hsa:27338 UBE2S

Monarch:27338 UBE2S

NCBI Gene:27338 UBE2S

OMIM:610309 UBE2S

UCSC:Q16763 UBE2S

Reference Transcript

RefSeq:NM_014501.2 UBE2S

Other Identifiers

11719849_s_at

16875763

202779_PM_s_at

202779_s_at

27338

3713481

3713482

3713483

3713484

3747002

3747003

3747004

3747005

3747006

3871444

3871446

3871447

3871450

3871451

3871452

3871453

3871455

3871456

40619_at

8012958

8039491

893_at

894_g_at

A_32_P184933

GE58141

GO:0000209

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005680

GO:0005829

GO:0006511

GO:0010458

GO:0010994

GO:0010997

GO:0016567

GO:0016740

GO:0019787

GO:0030163

GO:0031145

GO:0032446

GO:0035519

GO:0036211

GO:0043161

GO:0043226

GO:0044314

GO:0051301

GO:0051603

GO:0061631

GO:0065003

GO:0070534

GO:0070979

GO:0085020

GO:0140096

GO:1904668

HMNXSV003019095

ILMN_1808591

ILMN_2217289

M91670_at

PH_hs_0030491

TC17001166.hg

TC19001872.hg

g7657045_3p_x_at

p8460

Participates

as a member of

E2 ubiquitin conjugating enzyme (UBA1 substrate) [nucleoplasm] (Homo sapiens)

as a component of

Other forms of this molecule

Ub-C95-UBE2S [cytosol]

Ub-C95-UBE2S [nucleoplasm]

UBE2S [cytosol]

Inferred To

UBE2S [nucleoplasm] (Bos taurus)

UBE2S [nucleoplasm] (Canis familiaris)

UBE2S [nucleoplasm] (Drosophila melanogaster)

UBE2S [nucleoplasm] (Gallus gallus)

UBE2S [nucleoplasm] (Sus scrofa)

ube2s [nucleoplasm] (Danio rerio)

ube2s [nucleoplasm] (Dictyostelium discoideum)

Ghost homologue of UBE2S [nucleoplasm] (Xenopus tropicalis)

Ube2s [nucleoplasm] (Mus musculus)

Ube2s [nucleoplasm] (Rattus norvegicus)

Cross References

RefSeq

NP_055316.2

ENSEMBL

ENST00000264552, ENSP00000264552

OpenTargets

ENSG00000108106

HPA

ENSG00000108106-UBE2S

PRO

Q16763

Pharos - Targets

Q16763

HMDB Protein

HMDBP09277

PDB

6S96, 5L9T, 7AHF, 6S98, 6QH3, 6QHK, 8TAU, 5BNB, 1ZDN

Interactors (1)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) CFTR [plasma membrane] (R-HSA-383188) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR G542* [plasma membrane] (R-HSA-5678986) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) ub-CFTR F508del [cytosol] (R-HSA-8866838) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR [endosome membrane] (R-HSA-6782965) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [lysosomal membrane] (R-HSA-5627279) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104)	0.483	3

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