Reactome | Ub-C88-UBE2A [nucleoplasm]

Ub-C88-UBE2A [nucleoplasm]

Stable Identifier

R-HSA-8864186

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

nucleoplasm

Synonyms

Ubiquitin-conjugating enzyme E2 A ecNumber evidence="5"2.3.2.23/ecNumber, UBE2A_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:P49459 UBE2A

Gene Names

UBE2A, RAD6A

Chain

chain:1-152

Reference Genes

BioGPS Gene:7319 UBE2A

COSMIC (genes):UBE2A UBE2A

CTD Gene:7319 UBE2A

dbSNP Gene:7319 UBE2A

ENSEMBL:ENSG00000077721 UBE2A

ENSEMBL_homo_sapiens_GENE:ENSG00000077721.17 UBE2A

HGNC:12472 UBE2A

KEGG Gene (Homo sapiens):7319 UBE2A

Monarch:7319 UBE2A

NCBI Gene:7319 UBE2A

OMIM:312180 UBE2A

UCSC:P49459 UBE2A

Reference Transcript

Other Identifiers

11716265_a_at

11716266_s_at

11740193_s_at

17106587

201898_PM_s_at

201898_s_at

201899_PM_s_at

201899_s_at

3988875

3988876

3988877

3988878

3988887

3988890

3988893

3988894

3988895

7319

8169645

890_at

A_14_P135088

A_23_P148446

A_33_P3341189

GE58069

GO:0000086

GO:0000166

GO:0000209

GO:0000278

GO:0000785

GO:0003824

GO:0004842

GO:0005515

GO:0005524

GO:0005634

GO:0005654

GO:0005694

GO:0005829

GO:0006281

GO:0006301

GO:0006325

GO:0006338

GO:0006511

GO:0006974

GO:0009411

GO:0016567

GO:0016740

GO:0019787

GO:0030163

GO:0031625

GO:0032446

GO:0033503

GO:0036211

GO:0043130

GO:0043161

GO:0043226

GO:0061631

GO:0070936

GO:0070979

GO:0140096

GO:0140852

HMNXSV003042605

Hs.80612.0.S1_3p_a_at

ILMN_2307455

M74524_at

PH_hs_0018434

TC0X000587.hg

g4507768_3p_a_at

Participates

as a member of

Other forms of this molecule

UBE2A [cytosol]

UBE2A [nucleoplasm]

Inferred To

Ub-C88-UBE2A [nucleoplasm] (Plasmodium falciparum)

ubc2 [nucleoplasm] (Dictyostelium discoideum)

mp:zf637-2-000771 [nucleoplasm] (Danio rerio)

rhp6 [nucleoplasm] (Schizosaccharomyces pombe)

ube2a [nucleoplasm] (Xenopus tropicalis)

UBE2A [nucleoplasm] (Bos taurus)

UBE2A [nucleoplasm] (Canis familiaris)

UBE2A [nucleoplasm] (Gallus gallus)

UBE2A [nucleoplasm] (Sus scrofa)

RAD6 [nucleoplasm] (Saccharomyces cerevisiae)

ubc-1 [nucleoplasm] (Caenorhabditis elegans)

Ubc6 [nucleoplasm] (Drosophila melanogaster)

Ube2a [nucleoplasm] (Mus musculus)

Ube2a [nucleoplasm] (Rattus norvegicus)

Modified Residues

Name

S-(glycyl)-L-cysteine (Cys-Gly) at 88

Coordinate

PsiMod Name

S-(glycyl)-L-cysteine (Cys-Gly)

PsiMod Definition

A protein modification that effectively crosslinks an L-cysteine residue and a glycine residue by a thioester bond to form S-glycyl-L-cysteine.

Cross References

RefSeq

NP_003327.2, NP_001269090.1, NP_861427.1

OpenTargets

ENSG00000077721

IntEnz

2.3.2.23

GeneCards

P49459

HPA

ENSG00000077721-UBE2A

Ensembl

ENST00000371558, ENST00000630695, ENSP00000486599, ENSP00000512695, ENSG00000077721, ENSP00000486550, ENST00000696534, ENSP00000360613, ENST00000625938

PRO

P49459

Pharos - Targets

P49459

Orphanet

17261

HMDB Protein

HMDBP00560

PDB

6CYO, 6CYR, 8IEJ

Interactors (7)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:O00560 SDCBP	3	SDCBP [extracellular region] (R-HSA-6806206) SDCBP [azurophil granule lumen] (R-HSA-6799372) SDCBP [cytosol] (R-HSA-373639)	0.718	9
UniProt:Q8WZA2 RAPGEF4	1	RAPGEF4 [plasma membrane] (R-HSA-3008666)	0.556	3
UniProt:P54652 HSPA2	2	HSPA2 [cytosol] (R-HSA-3371408) HSPA2 [nucleoplasm] (R-HSA-912480)	0.556	3
UniProt:Q96CV9 OPTN	5	OPTN [recycling endosome membrane] (R-HSA-8854141) OPTN [Golgi membrane] (R-HSA-2161111) p-S177-OPTN [nucleoplasm] (R-HSA-2562595) p-S177-OPTN [cytosol] (R-HSA-2562525) OPTN [cytosol] (R-HSA-9687907)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:P55212 CASP6	5	CASP6 (1-293) [cytosol] (R-HSA-6798132) CASP6(194-293) [nucleoplasm] (R-HSA-352246) CASP6(24-179) [nucleoplasm] (R-HSA-352247) CASP6(24-179) [cytosol] (R-HSA-350313) CASP6(194-293) [cytosol] (R-HSA-266128)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3

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