Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Funding
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Digital Preservation
Contact us
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Cytomics
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Curator Guide
Release Documentation
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Advanced Data Search
Site Search
Community
Contribute Pathway Knowledge
Icon Library
Outreach
Events
Publications
Partners
Contributors
Resources Guide
Download
Search ...
Go!
UBR4 [plasma membrane]
Stable Identifier
R-HSA-6801583
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
plasma membrane
Synonyms
E3 ubiquitin-protein ligase UBR4, UBR4_HUMAN
Locations in the PathwayBrowser
Expand all
Immune System (Homo sapiens)
Innate Immune System (Homo sapiens)
Neutrophil degranulation (Homo sapiens)
Exocytosis of ficolin-rich granule membrane proteins (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
UBR4 [plasma membrane] (Homo sapiens)
Exocytosis of specific granule membrane proteins (Homo sapiens)
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
UBR4 [plasma membrane] (Homo sapiens)
Exocytosis of tertiary granule membrane proteins (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
UBR4 [plasma membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q5T4S7 UBR4
Gene Names
UBR4, KIAA0462, KIAA1307, RBAF600, ZUBR1
Chain
chain:1-5183
Reference Genes
BioGPS Gene:23352 UBR4
COSMIC (genes):UBR4 UBR4
CTD Gene:23352 UBR4
dbSNP Gene:23352 UBR4
ENSEMBL:ENSG00000127481 UBR4
ENSEMBL_homo_sapiens_GENE:ENSG00000127481.15 UBR4
HGNC:30313 UBR4
KEGG Gene (Homo sapiens):23352 UBR4
Monarch:23352 UBR4
NCBI Gene:23352 UBR4
OMIM:609890 UBR4
UCSC:Q5T4S7 UBR4
Reference Transcript
RefSeq:NM_020765.2 UBR4
Other Identifiers
11755851_a_at
16682499
211950_PM_at
211950_at
215636_3p_at
215636_PM_at
215636_at
23352
2399410
2399411
2399412
2399416
2399419
2399422
2399431
2399432
2399433
2399434
2399436
2399437
2399438
2399441
2399442
2399443
2399444
2399445
2399448
2399449
2399450
2399455
2399456
2399457
2399458
2399460
2399461
2399462
2399463
2399465
2399466
2399467
2399468
2399469
2399470
2399471
2399472
2399473
2399474
2399475
2399476
2399477
2399479
2399481
2399482
2399483
2399484
2399485
2399486
2399487
2399488
2399489
2399490
2399491
2399493
2399497
2399499
2399502
2399505
2399506
2399507
2399514
2399515
2399517
2399518
2399520
2399521
2399524
2399525
2399526
2399529
2399530
2399532
2399534
2399540
2399541
2399542
2399543
2399544
2399545
2399546
2399547
2399548
2399549
2399550
2399551
2399553
2399554
2399556
2399557
2399558
2399559
2399560
2399561
2399562
2399563
2399564
2399565
2399566
2399567
2399568
2399569
2399570
2399571
2399572
2399573
2399574
2399575
2399576
2399578
2399579
2399580
2399583
2399584
2399585
2399587
2399588
2399589
2399590
2399591
2399592
2399595
2399596
2399597
2399598
2399599
2399600
2399601
2399602
2399603
2399604
2399605
2399610
2399611
2399612
33860_at
7913001
A_24_P923945
A_33_P3767773
GE86760
GO:0003824
GO:0004842
GO:0005515
GO:0005516
GO:0005634
GO:0005654
GO:0005737
GO:0005813
GO:0005815
GO:0005829
GO:0005856
GO:0005886
GO:0006511
GO:0006629
GO:0008270
GO:0016020
GO:0016567
GO:0016740
GO:0030163
GO:0031410
GO:0035579
GO:0036211
GO:0043226
GO:0045717
GO:0046872
GO:0061630
GO:0070821
GO:0101003
GO:0140096
HMNXSV003042620
HMNXSV003055010
Hs.297641.0.S1_3p_at
Hs.306634.0.S1_3p_x_at
ILMN_1699226
PH_hs_0014887
TC01002293.hg
Participates
as a member of
Specific granule membrane proteins [plasma membrane] (Homo sapiens)
Ficolin-rich granule membrane proteins [plasma membrane] (Homo sapiens)
Tertiary granule membrane proteins [plasma membrane] (Homo sapiens)
Other forms of this molecule
UBR4 [specific granule membrane]
UBR4 [ficolin-1-rich granule membrane]
UBR4 [tertiary granule membrane]
UBR4 [cytosol]
Inferred To
UBR4 [plasma membrane]
(Bos taurus)
UBR4 [plasma membrane]
(Canis familiaris)
UBR4 [plasma membrane]
(Dictyostelium discoideum)
UBR4 [plasma membrane]
(Drosophila melanogaster)
UBR4 [plasma membrane]
(Mus musculus)
UBR4 [plasma membrane]
(Rattus norvegicus)
UBR4 [plasma membrane]
(Sus scrofa)
ubr-4 [plasma membrane]
(Caenorhabditis elegans)
Cross References
RefSeq
NP_065816.2
OpenTargets
ENSG00000127481
IntEnz
2.3.2.27
GeneCards
Q5T4S7
HPA
ENSG00000127481-UBR4
Ensembl
ENSG00000127481
,
ENST00000375254
,
ENSP00000364403
,
ENSP00000364366
,
ENST00000375218
PRO
Q5T4S7
Pharos - Targets
Q5T4S7
HMDB Protein
HMDBP09275
PDB
8J9Q
,
8BTL
,
8J9R
,
8B5W
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P13569 CFTR
17
PolyUb-CFTR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869104)
PolyUb-CFTR [plasma membrane]
(R-HSA-8867595)
CFTR [lysosomal membrane]
(R-HSA-5627279)
CFTR [Golgi-associated vesicle membrane]
(R-HSA-5627079)
CFTR [endosome membrane]
(R-HSA-6782965)
PolyUb-CFTR [endosome membrane]
(R-HSA-6782976)
CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866834)
ub-CFTR F508del [cytosol]
(R-HSA-8866838)
ub-CFTR F508del [endoplasmic reticulum membrane]
(R-HSA-8866842)
CFTR G542* [plasma membrane]
(R-HSA-5678986)
CFTR G551D [plasma membrane]
(R-HSA-5678977)
CFTR W1282* [plasma membrane]
(R-HSA-5678976)
CFTR F508del [plasma membrane]
(R-HSA-5678978)
CFTR N1303K [plasma membrane]
(R-HSA-5678983)
CFTR [plasma membrane]
(R-HSA-383188)
CFTR [endoplasmic reticulum membrane]
(R-HSA-8866837)
misfolded CFTR [endoplasmic reticulum membrane]
(R-HSA-8868730)
0.706
15
UniProt:P19320 VCAM1
1
VCAM1 [plasma membrane]
(R-HSA-197834)
0.527
4
© 2024
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text