Reactome | UBR4 [specific granule membrane]

UBR4 [specific granule membrane]

Stable Identifier

R-HSA-6801492

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

specific granule membrane

Synonyms

E3 ubiquitin-protein ligase UBR4, UBR4_HUMAN

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:Q5T4S7 UBR4

Gene Names

UBR4, KIAA0462, KIAA1307, RBAF600, ZUBR1

Chain

chain:1-5183

Reference Genes

BioGPS Gene:23352 UBR4

COSMIC (genes):UBR4 UBR4

CTD Gene:23352 UBR4

dbSNP Gene:23352 UBR4

ENSEMBL:ENSG00000127481 UBR4

ENSEMBL_homo_sapiens_GENE:ENSG00000127481.15 UBR4

HGNC:30313 UBR4

Monarch:23352 UBR4

NCBI Gene:23352 UBR4

OMIM:609890 UBR4

UCSC:Q5T4S7 UBR4

Reference Transcript

RefSeq:NM_020765.2 UBR4

Other Identifiers

11755851_a_at

16682499

211950_PM_at

211950_at

215636_3p_at

215636_PM_at

215636_at

23352

2399410

2399411

2399412

2399416

2399419

2399422

2399431

2399432

2399433

2399434

2399436

2399437

2399438

2399441

2399442

2399443

2399444

2399445

2399448

2399449

2399450

2399455

2399456

2399457

2399458

2399460

2399461

2399462

2399463

2399465

2399466

2399467

2399468

2399469

2399470

2399471

2399472

2399473

2399474

2399475

2399476

2399477

2399479

2399481

2399482

2399483

2399484

2399485

2399486

2399487

2399488

2399489

2399490

2399491

2399493

2399497

2399499

2399502

2399505

2399506

2399507

2399514

2399515

2399517

2399518

2399520

2399521

2399524

2399525

2399526

2399529

2399530

2399532

2399534

2399540

2399541

2399542

2399543

2399544

2399545

2399546

2399547

2399548

2399549

2399550

2399551

2399553

2399554

2399556

2399557

2399558

2399559

2399560

2399561

2399562

2399563

2399564

2399565

2399566

2399567

2399568

2399569

2399570

2399571

2399572

2399573

2399574

2399575

2399576

2399578

2399579

2399580

2399583

2399584

2399585

2399587

2399588

2399589

2399590

2399591

2399592

2399595

2399596

2399597

2399598

2399599

2399600

2399601

2399602

2399603

2399604

2399605

2399610

2399611

2399612

33860_at

7913001

A_24_P923945

A_33_P3767773

GE86760

GO:0003824

GO:0004842

GO:0005515

GO:0005516

GO:0005634

GO:0005654

GO:0005737

GO:0005813

GO:0005815

GO:0005829

GO:0005856

GO:0005886

GO:0006511

GO:0006629

GO:0008270

GO:0016020

GO:0016567

GO:0016740

GO:0030163

GO:0031410

GO:0035579

GO:0036211

GO:0043226

GO:0045717

GO:0046872

GO:0061630

GO:0070821

GO:0101003

GO:0140096

HMNXSV003042620

HMNXSV003055010

Hs.297641.0.S1_3p_at

Hs.306634.0.S1_3p_x_at

ILMN_1699226

PH_hs_0014887

TC01002293.hg

Participates

as a member of

Specific granule membrane proteins [specific granule membrane] (Homo sapiens)

Other forms of this molecule

UBR4 [ficolin-1-rich granule membrane]

UBR4 [plasma membrane]

UBR4 [tertiary granule membrane]

UBR4 [cytosol]

Inferred To

poe [specific granule membrane] (Drosophila melanogaster)

Ubr4 [specific granule membrane] (Mus musculus)

Ubr4 [specific granule membrane] (Rattus norvegicus)

UBR4 [specific granule membrane] (Bos taurus)

UBR4 [specific granule membrane] (Canis familiaris)

UBR4 [specific granule membrane] (Dictyostelium discoideum)

UBR4 [specific granule membrane] (Sus scrofa)

ubr-4 [specific granule membrane] (Caenorhabditis elegans)

Cross References

RefSeq

NP_065816.2

OpenTargets

ENSG00000127481

IntEnz

2.3.2.27

GeneCards

Q5T4S7

HPA

ENSG00000127481-UBR4

Ensembl

ENSP00000364403, ENST00000375254, ENST00000375218, ENSG00000127481, ENSP00000364366

PRO

Q5T4S7

Pharos - Targets

Q5T4S7

HMDB Protein

HMDBP09275

Interactors (2)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P13569 CFTR	17	PolyUb-CFTR [clathrin-coated endocytic vesicle membrane] (R-HSA-8869104) PolyUb-CFTR [plasma membrane] (R-HSA-8867595) CFTR [lysosomal membrane] (R-HSA-5627279) CFTR [Golgi-associated vesicle membrane] (R-HSA-5627079) CFTR [endosome membrane] (R-HSA-6782965) PolyUb-CFTR [endosome membrane] (R-HSA-6782976) CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866834) ub-CFTR F508del [cytosol] (R-HSA-8866838) ub-CFTR F508del [endoplasmic reticulum membrane] (R-HSA-8866842) CFTR G542* [plasma membrane] (R-HSA-5678986) CFTR G551D [plasma membrane] (R-HSA-5678977) CFTR W1282* [plasma membrane] (R-HSA-5678976) CFTR F508del [plasma membrane] (R-HSA-5678978) CFTR N1303K [plasma membrane] (R-HSA-5678983) CFTR [plasma membrane] (R-HSA-383188) CFTR [endoplasmic reticulum membrane] (R-HSA-8866837) misfolded CFTR [endoplasmic reticulum membrane] (R-HSA-8868730)	0.706	15
UniProt:P19320 VCAM1	1	VCAM1 [plasma membrane] (R-HSA-197834)	0.527	4