Reactome | ESR-mediated signaling

ESR-mediated signaling

Stable Identifier

R-HSA-8939211

DOI

10.3180/R-HSA-8939211.1

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

Locations in the PathwayBrowser

Expand all

General

SBML | | PDF

SVG | | PPTX | SBGN

Click the image above or here to open this pathway in the Pathway Browser

Estrogens are a class of hormones that play a role in physiological processes such as development, reproduction, metabolism of liver, fat and bone, and neuronal and cardiovascular function (reviewed in Arnal et al, 2017; Haldosen et al, 2014). Estrogens bind estrogen receptors, members of the nuclear receptor superfamily. Ligand-bound estrogen receptors act as nuclear transcription factors to regulate expression of genes that control cellular proliferation and differentiation, among other processes, but also play a non-genomic role in rapid signaling from the plasma membrane (reviewed in Hah et al, 2014;Schwartz et al, 2016).

Literature References

PubMed ID	Title	Journal	Year
28539435	Membrane and Nuclear Estrogen Receptor Alpha Actions: From Tissue Specificity to Medical Implications Arnal, JF, Lenfant, F, Métivier, R, Flouriot, G, Henrion, D, Adlanmerini, M, Fontaine, C, Gourdy, P, Chambon, P, Katzenellenbogen, B, Katzenellenbogen, J	Physiol. Rev.	2017
23810978	Hormone-regulated transcriptomes: lessons learned from estrogen signaling pathways in breast cancer cells Hah, N, Kraus, WL	Mol. Cell. Endocrinol.	2014
23954741	Estrogen receptor beta in breast cancer Haldosén, LA, Zhao, C, Dahlman-Wright, K	Mol. Cell. Endocrinol.	2014
27288742	Rapid steroid hormone actions via membrane receptors Schwartz, N, Verma, A, Bivens, CB, Schwartz, Z, Boyan, BD	Biochim. Biophys. Acta	2016