RHOD GTPase cycle

Stable Identifier
Homo sapiens
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This pathway catalogues RHOD GTPase activator proteins (GAPs) and RHOD effectors. RHOD possesses GTPase activity and is therefore grouped with classical RHO GTPases but it is atypical in the sense that no known guanine nucleotide exchange factors (GEFs) and no GDP dissociation inhibitors (GDIs) (Blom et al. 2017) are involved in the regulation of RHOD activity. RHOD possesses an elevated intrinsic guanine nucleotide exchange activity and auto-activates (Jaiswal, Fansa et al. 2013). RHOD regulates cytoskeletal dynamics and intracellular transport of vesicles (Gad and Aspenstrom 2010; Aspenstrom et al. 2014), especially actin-dependent movement of endosomes (Gasman et al. 2003, reviewed in Randazzo 2003).
Literature References
PubMed ID Title Journal Year
24622787 Atypical Rho GTPases RhoD and Rif integrate cytoskeletal dynamics and membrane trafficking

Aspenström, P

Biol. Chem. 2014
12636908 RhoD, Src, and hDia2C in endosome motility

Randazzo, PA

Dev. Cell 2003
19818399 Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking

Gad, AK, Aspenström, P

Cell. Signal. 2010
28196728 The atypical Rho GTPase RhoD is a regulator of actin cytoskeleton dynamics and directed cell migration

Blom, M, Reis, K, Kreuger, J, Heldin, J, Aspenström, P

Exp. Cell Res. 2017
23096567 New insight into the molecular switch mechanism of human Rho family proteins: shifting a paradigm

Ahmadian, MR, Jaiswal, M, Fansa, EK, Dvorsky, R

Biol. Chem. 2013
12577064 RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase

Kalaidzidis, Y, Gasman, S, Zerial, M

Nat. Cell Biol. 2003
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