Reactome | RHOJ GTPase cycle

RHOJ GTPase cycle

Stable Identifier

R-HSA-9013409

DOI

10.3180/R-HSA-9013409.2

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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This pathway catalogues RHOJ (also known as TCL or RHOI) guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), and RHOJ effectors. No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOJ. RHOJ, together with RHOQ (TC10), belongs to the CDC42 subfamily of RHO GTPases and shares 85% and 78% amino acid similarity with RHOQ and CDC42, respectively (Vignal et al. 2000). RHOJ regulates the cytoskeleton, including formation of lamellipodia and actin filaments (Vignal et al. 2000, Abe et al. 2003, Aspenstrom et al. 2004, Shi et al. 2016). RHOJ is highly expressed in endothelial cells, regulating their motility and, consequently, vascular morphogenesis (Leszczynska et al. 2011; Shi et al. 2016). As a part of the VEGF signaling cascade, RHOJ promotes retinal angiogenesis (Fukushima et al. 2013). RHOJ plays a role in cancer cell migration and cancer-related angiogenesis (Shi et al. 2016). RHOJ is involved in adipocyte differentiation (Nishizuka 2003; Shi et al. 2016).

Literature References

PubMed ID	Title	Journal	Year
27556037	The Role of RhoJ in Endothelial Cell Biology and Tumor Pathology Xiao, HT, Shi, TT, Li, G	Biomed Res Int	2016
24397187	[RhoJ signaling pathway in retinal angiogenesis: promising targets for novel anti-angiogenic therapy] Fukushima, Y	Nippon Ganka Gakkai Zasshi	2013
14521508	Rho GTPases have diverse effects on the organization of the actin filament system Aspenstrom, P, Saras, J, Fransson, A	Biochem J	2004
22103495	The role of RhoJ in endothelial cell biology and angiogenesis Heath, VL, Leszczynska, K, Bicknell, R, Kaur, S, Wilson, E	Biochem. Soc. Trans.	2011
12456725	Small GTPase Tc10 and its homologue RhoT induce N-WASP-mediated long process formation and neurite outgrowth Kato, M, Takenawa, T, Miki, H, Endo, T, Abe, T	J. Cell. Sci.	2003
14631756	[Cloning and characterization of inducible genes at the beginning of adipocyte differentiation] Nishizuka, M	Yakugaku Zasshi	2003
10967094	Characterization of TCL, a new GTPase of the rho family related to TC10 andCcdc42 Blangy, A, Gauthier-Rouvière, C, Vignal, E, De Toledo, M, Ladopoulou, A, Comunale, F, Fort, P	J. Biol. Chem.	2000