This pathway catalogues RHOJ (also known as TCL or RHOI) guanine nucleotide exchange factors (GEFs), GTPase activator proteins (GAPs), and RHOJ effectors. No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOJ. RHOJ, together with RHOQ (TC10), belongs to the CDC42 subfamily of RHO GTPases and shares 85% and 78% amino acid similarity with RHOQ and CDC42, respectively (Vignal et al. 2000). RHOJ regulates the cytoskeleton, including formation of lamellipodia and actin filaments (Vignal et al. 2000, Abe et al. 2003, Aspenstrom et al. 2004, Shi et al. 2016). RHOJ is highly expressed in endothelial cells, regulating their motility and, consequently, vascular morphogenesis (Leszczynska et al. 2011; Shi et al. 2016). As a part of the VEGF signaling cascade, RHOJ promotes retinal angiogenesis (Fukushima et al. 2013). RHOJ plays a role in cancer cell migration and cancer-related angiogenesis (Shi et al. 2016). RHOJ is involved in adipocyte differentiation (Nishizuka 2003; Shi et al. 2016).
Xiao, HT, Shi, TT, Li, G
Fukushima, Y
Aspenstrom, P, Saras, J, Fransson, A
Heath, VL, Leszczynska, K, Bicknell, R, Kaur, S, Wilson, E
Kato, M, Takenawa, T, Miki, H, Endo, T, Abe, T
Nishizuka, M
Blangy, A, Gauthier-Rouvière, C, Vignal, E, De Toledo, M, Ladopoulou, A, Comunale, F, Fort, P
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