Reactome | RHOF GTPase cycle

RHOF GTPase cycle

Stable Identifier

R-HSA-9035034

DOI

10.3180/R-HSA-9035034.2

Type

Pathway

Species

Homo sapiens

ReviewStatus

5/5

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This pathway catalogues RHOF (RIF) GTPase activator proteins (GAPs) and RHOF effectors. RHOF GTPase is thought to exist in the active GTP-bound state in the absence of any GEF activity (Tian et al. 2017). No GDP dissociation inhibitors (GDIs) have been shown to interact with RHOF. RHOF is only found in vertebrates (Gad and Aspenstrom 2010; Fan and Mellor 2012). RHOF regulates cytoskeletal dynamics (Gad and Aspenstrom 2010; Aspenstrom et al. 2014) and promotes the formation of filopodia and stress fibers (Fan and Mellor 2012). RHOF may be involved in actin remodelling in lymphocyte microvilli (Fan and Mellor 2012). In neurons, RHOF contributes to the formation of dendritic spines (Fan and Mellor 2012).

Literature References

PubMed ID	Title	Journal	Year
24622787	Atypical Rho GTPases RhoD and Rif integrate cytoskeletal dynamics and membrane trafficking Aspenström, P	Biol. Chem.	2014
19818399	Rif proteins take to the RhoD: Rho GTPases at the crossroads of actin dynamics and membrane trafficking Gad, AK, Aspenström, P	Cell. Signal.	2010
28098758	Neurotrophin Promotes Neurite Outgrowth by Inhibiting Rif GTPase Activation Downstream of MAPKs and PI3K Signaling Wang, J, Tian, X, Yan, H, Wu, S, Fan, L, Li, J	Int J Mol Sci	2017
22260703	The small Rho GTPase Rif and actin cytoskeletal remodelling Mellor, H, Fan, L	Biochem. Soc. Trans.	2012