Toggle navigation
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
About
What is Reactome ?
News
Team
Scientific Advisory Board
Editorial Calendar
Release Calendar
Statistics
Our Logo
License Agreement
Privacy Notice
Disclaimer
Content
Table of Contents
DOIs
Data Schema
Reactome Research Spotlight
ORCID Integration Project
COVID-19 Disease Pathways
Docs
Userguide
Pathway Browser
How do I search ?
Details Panel
Analysis Tools
Analysis Data
Analysis Gene Expression
Species Comparison
Tissue Distribution
Diseases
Review Status of Reactome Events
ReactomeFIViz
Developer's Zone
Graph Database
Analysis Service
Content Service
Pathways Overview
Pathway Diagrams
Icon Info
EHLD Specs & Guidelines
Icon Library Guidelines
Data Model
Computationally inferred events
FAQ
Linking to Us
Citing us
Tools
Pathway Browser
Analyse gene list
Analyse gene expression
Species Comparison
Tissue Distribution
Analysis Service
Content Service
ReactomeFIViz
Overlays
DisGeNET
Web
API
Advanced Data Search
Site Search
Community
Icon Library
Outreach
Events
Training
Publications
Partners
Papers Citing Us
Resources Guide
Collaboration
Download
Search ...
Go!
GRIN1 [transport vesicle membrane]
Stable Identifier
R-HSA-9610565
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
transport vesicle membrane
Synonyms
Glutamate (NMDA) receptor subunit zeta-1
Locations in the PathwayBrowser
Expand all
Neuronal System (Homo sapiens)
Transmission across Chemical Synapses (Homo sapiens)
Neurotransmitter receptors and postsynaptic signal transmission (Homo sapiens)
Activation of NMDA receptors and postsynaptic events (Homo sapiens)
Assembly and cell surface presentation of NMDA receptors (Homo sapiens)
GluN1:GluN2B (GRIN1:GRIN2B) di-heterotetramers bind LIN7:CASK:APBA1, DLG1 and KIF17 (Homo sapiens)
GRIN1:GRIN2B di-heterotetramer:LIN7:CASK:APBA1:DLG1:KIF17:Microtubule [transport vesicle membrane] (Homo sapiens)
GRIN1:GRIN2B di-heterotetramer [transport vesicle membrane] (Homo sapiens)
GRIN1 [transport vesicle membrane] (Homo sapiens)
KIF17 transports GluN1:GluN2B (GRIN1:GRIN2B) NMDA receptors to the plasma membrane (Homo sapiens)
GRIN1:GRIN2B di-heterotetramer:LIN7:CASK:APBA1:DLG1:KIF17:Microtubule [transport vesicle membrane] (Homo sapiens)
GRIN1:GRIN2B di-heterotetramer [transport vesicle membrane] (Homo sapiens)
GRIN1 [transport vesicle membrane] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q05586 GRIN1
Gene Names
GRIN1, NMDAR1
Chain
signal peptide:1-18, chain:19-938
Reference Genes
BioGPS Gene:2902 GRIN1
COSMIC (genes):GRIN1 GRIN1
CTD Gene:2902 GRIN1
dbSNP Gene:2902 GRIN1
ENSEMBL:ENSG00000176884 GRIN1
ENSEMBL:ENSG00000176884.17 GRIN1
HGNC:4584 GRIN1
KEGG Gene (Homo sapiens):2902 GRIN1
Monarch:2902 GRIN1
NCBI Gene:2902 GRIN1
OMIM:138249 GRIN1
UCSC:Q05586 GRIN1
Reference Transcript
RefSeq:NM_000832.6 GRIN1
RefSeq:NM_007327.3 GRIN1
RefSeq:NM_001185090.1 GRIN1
RefSeq:NM_021569.3 GRIN1
RefSeq:NM_001185091.1 GRIN1
RefSeq:XM_005266071.3 GRIN1
RefSeq:XM_005266073.4 GRIN1
Other Identifiers
11733427_x_at
11746377_a_at
11750613_a_at
11750614_x_at
17091610
205914_3p_s_at
205914_PM_s_at
205914_s_at
205915_PM_x_at
205915_x_at
210781_PM_x_at
210781_x_at
210782_3p_x_at
210782_PM_x_at
210782_x_at
211125_PM_x_at
211125_x_at
2902
3195239
3195240
3195247
3195249
3195259
3195261
3195266
3195268
3195269
3195271
3195273
3195274
3195275
3195276
3195278
3195279
3195280
3195281
3195282
3195283
3195287
3195288
3195289
3195290
3195291
3195292
3195293
37134_f_at
37135_f_at
4050463
4050481
4050489
4050491
8159583
A_23_P257962
A_23_P84670
A_23_P96072
A_33_P3348127
GE54128
GE590437
GO:0001540
GO:0004970
GO:0004972
GO:0005215
GO:0005216
GO:0005262
GO:0005509
GO:0005515
GO:0005516
GO:0005576
GO:0005737
GO:0005783
GO:0005789
GO:0005886
GO:0006351
GO:0006355
GO:0006811
GO:0006812
GO:0007215
GO:0007268
GO:0007420
GO:0008021
GO:0008542
GO:0009986
GO:0010524
GO:0014069
GO:0015276
GO:0016020
GO:0016594
GO:0016595
GO:0017146
GO:0018964
GO:0019722
GO:0022849
GO:0023052
GO:0030425
GO:0031410
GO:0035235
GO:0038023
GO:0042165
GO:0042221
GO:0042391
GO:0043005
GO:0043083
GO:0043195
GO:0043197
GO:0043226
GO:0044877
GO:0045202
GO:0045211
GO:0045471
GO:0045944
GO:0048167
GO:0048168
GO:0048856
GO:0050877
GO:0051290
GO:0051968
GO:0055065
GO:0055074
GO:0055085
GO:0060076
GO:0060079
GO:0060089
GO:0065003
GO:0097060
GO:0097553
GO:0098655
GO:0098976
GO:1903428
GO:1904062
GO:1905429
GO:2000463
GO:2001056
HMNXSV003001126
ILMN_1659199
ILMN_1805404
ILMN_2321301
L13266_s_at
PH_hs_0027515
TC09002887.hg
g11038636_3p_a_at
g219919_3p_a_at
g2343288_3p_a_at
g307302_3p_a_at
g307302_3p_x_at
Participates
as a component of
GRIN1:GRIN2B di-heterotetramer [transport vesicle membrane] (Homo sapiens)
Other forms of this molecule
GRIN1 [endoplasmic reticulum membrane]
GRIN1 [plasma membrane]
Cross References
RefSeq
NP_001172019.1
,
NP_001172020.1
,
XP_005266128.1
,
XP_005266130.1
,
NP_015566.1
,
NP_067544.1
,
NP_000823.4
ZINC - World Drugs
NMDZ1_HUMAN
Guide to Pharmacology - Targets
455
OpenTargets
ENSG00000176884
ZINC - FDA approved
NMDZ1_HUMAN
ZINC - Substances
NMDZ1_HUMAN
ZINC target
Q05586
PRO
Q05586
PDB
5TP9
,
6IRH
,
7EU7
,
7EOQ
,
6IRG
,
7EU8
,
8E92
,
5H8H
,
7EOR
,
5H8F
,
6IRF
,
5KCJ
,
8E93
,
7EOS
,
6IRA
,
8E94
,
7EOT
,
3BYA
,
2NR1
,
8E96
,
7EOU
,
2HQW
,
7YFM
,
5KDT
,
5I2N
,
8E97
,
5I2K
,
8E98
,
5TPA
,
5H8Q
,
8E99
,
5H8N
HPA
ENSG00000176884-GRIN1
GeneCards
Q05586
Ensembl
ENST00000371559
,
ENST00000371553
,
ENST00000371546
,
ENST00000371560
,
ENSP00000360608
,
ENSP00000360616
,
ENSP00000360601
,
ENST00000371561
,
ENSG00000176884
,
ENST00000371550
,
ENSP00000360614
,
ENSP00000360615
,
ENSP00000360605
Pharos - Targets
Q05586
ZINC - Predictions - Purchasable
NMDZ1_HUMAN
Orphanet
20558
HMDB Protein
HMDBP01635
Interactors (2)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P35637 FUS
1
FUS [nucleoplasm]
(R-HSA-72040)
0.556
3
UniProt:P05067 APP
20
APP(18-770) [trans-Golgi network membrane]
(R-HSA-5229136)
APP-C99 [cytosol]
(R-HSA-9617603)
APP(18-770) [extracellular region]
(R-HSA-49335)
APP(18-770) [platelet alpha granule lumen]
(R-HSA-139835)
APP(18-687) [extracellular region]
(R-HSA-9010033)
APP(688-770) [plasma membrane]
(R-HSA-9010028)
APP(18-770) [Golgi lumen]
(R-HSA-8871509)
APP(18-770) [plasma membrane]
(R-HSA-9010038)
APP(18-671) [endosome lumen]
(R-HSA-5693003)
APP(714-770) [endosome lumen]
(R-HSA-6783325)
APP(712-770) [endosome lumen]
(R-HSA-6783331)
APP(672-770) [endosome lumen]
(R-HSA-9010082)
APP(672-713) [endosome lumen]
(R-HSA-5692993)
APP(672-711) [endosome lumen]
(R-HSA-6783333)
APP(18-770) [endosome lumen]
(R-HSA-5229077)
p-APP [endoplasmic reticulum lumen]
(R-HSA-8957012)
APP [endoplasmic reticulum lumen]
(R-HSA-8956696)
APP(672-711) [extracellular region]
(R-HSA-976740)
APP(672-711) [cytosol]
(R-HSA-877188)
APP(672-713) [extracellular region]
(R-HSA-879340)
0.556
3
© 2023
Reactome
Cite Us!
Cite Us!
Cite Us!
Warning!
Unable to extract citation. Please try again later.
Download As:
BibTeX
RIS
Text