Activation of AMPK downstream of NMDARs

Stable Identifier
R-HSA-9619483
Type
Pathway
Species
Homo sapiens
Compartment
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
Expand all
General
SVG | 
PNG
Low
Medium
High
 | PPTX  | SBGN
Activation of AMPK downstream of NMDARs
Click the image above or here to open this pathway in the Pathway Browser
Activation of NMDA receptors (NMDARs) leads to activation of AMP-activated kinase (AMPK) in a CAMKK2-dependent manner. Overactivation of CAMKK2 or AMPK in neurons can lead to dendritic spine loss and is implicated in synaptotoxicity of beta-amyloids in Alzheimer's disease (Mairet-Coello et al. 2013).
Literature References
PubMed ID Title Journal Year
23583109 The CAMKK2-AMPK kinase pathway mediates the synaptotoxic effects of Aβ oligomers through Tau phosphorylation

Courchet, V, Polleux, F, Pieraut, S, Courchet, J, Mairet-Coello, G, Maximov, A

Neuron 2013
Participants
Events
Participates
as an event of
Event Information
Go Biological Process
chemical synaptic transmission (0007268)
Cross References
BioModels Database
Authored
Orlic-Milacic, M  (2018-10-10)
Reviewed
Hansen, KB  (2018-11-02)
Yi, F  (2018-11-02)
Created
Orlic-Milacic, M  (2018-09-17)
Cite Us!