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Active FLT3 binds to GRB10
Stable Identifier
R-HSA-9706308
Type
Reaction [binding]
Species
Homo sapiens
Compartment
plasma membrane
,
cytosol
ReviewStatus
5/5
Locations in the PathwayBrowser
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Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Active FLT3 binds to GRB10 (Homo sapiens)
General
SBML
|
BioPAX
Level 2
Level 3
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PDF
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PNG
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PPTX
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SBGN
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The layout of this reaction may differ from that in the pathway view due to the constraints in pathway layout
Growth factor receptor-bound protein 10 (GRB10) can serve as an adaptor linking FLT3 to the p85 subunit of PI3 kinase, and thereby lead to activation of AKT signaling (Kazi and Ronnstrand, 2013; reviewed in Kazi and Ronnstrand, 2019).
Literature References
PubMed ID
Title
Journal
Year
31066629
FMS-like Tyrosine Kinase 3/FLT3: From Basic Science to Clinical Implications
Kazi, JU
,
Rönnstrand, L
Physiol. Rev.
2019
23246379
FLT3 signals via the adapter protein Grb10 and overexpression of Grb10 leads to aberrant cell proliferation in acute myeloid leukemia
Kazi, JU
,
Rönnstrand, L
Mol Oncol
2013
Participants
Input
Active FLT3 [plasma membrane]
(Homo sapiens)
GRB10 [cytosol]
(Homo sapiens)
Output
active FLT3:GRB10 [plasma membrane]
(Homo sapiens)
Participates
as an event of
FLT3 Signaling (Homo sapiens)
Orthologous Events
Active FLT3 binds to GRB10 (Bos taurus)
Active FLT3 binds to GRB10 (Canis familiaris)
Active FLT3 binds to GRB10 (Mus musculus)
Active FLT3 binds to GRB10 (Sus scrofa)
Authored
Rothfels, K (2020-11-06)
Reviewed
Kazi, JU (2020-11-06)
Created
Rothfels, K (2020-11-04)
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