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GRB10 [cytosol]
Stable Identifier
R-HSA-110009
Type
Protein [EntityWithAccessionedSequence]
Species
Homo sapiens
Compartment
cytosol
Synonyms
Growth factor receptor-bound protein 10, GRB10 adaptor protein, Insulin receptor binding protein GRB-IR
Locations in the PathwayBrowser
Expand all
Cellular responses to stimuli (Homo sapiens)
Cellular responses to stress (Homo sapiens)
Response of EIF2AK1 (HRI) to heme deficiency (Homo sapiens)
Expression of GRB10 (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
Developmental Biology (Homo sapiens)
Nervous system development (Homo sapiens)
Axon guidance (Homo sapiens)
RET signaling (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes bind GRB7,10 (Homo sapiens)
2x p-5Y-RET:GDNF:GFRA complexes:GRB7,GRB10 [plasma membrane] (Homo sapiens)
GRB7,GRB10 [cytosol] (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
GRB7,GRB10 [cytosol] (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
Immune System (Homo sapiens)
Cytokine Signaling in Immune system (Homo sapiens)
FLT3 Signaling (Homo sapiens)
Active FLT3 binds to GRB10 (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
active FLT3:GRB10 [plasma membrane] (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
FLT3 phosphorylates GRB10 (Homo sapiens)
active FLT3:GRB10 [plasma membrane] (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
Signal Transduction (Homo sapiens)
Signaling by Receptor Tyrosine Kinases (Homo sapiens)
Signaling by Insulin receptor (Homo sapiens)
Insulin receptor signalling cascade (Homo sapiens)
Binding of SHC1 to insulin receptor (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
GRB10:INSR [plasma membrane] (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
IRS activation (Homo sapiens)
Binding of IRS to insulin receptor (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
GRB10:INSR [plasma membrane] (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
Signal attenuation (Homo sapiens)
Binding of Grb10 to the insulin receptor (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
GRB10:INSR [plasma membrane] (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
Signaling by SCF-KIT (Homo sapiens)
Interaction of other adapter proteins with p-KIT (Homo sapiens)
Adapter proteins [cytosol] (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
Adapter proteins:p-KIT complex [plasma membrane] (Homo sapiens)
Adapter proteins [cytosol] (Homo sapiens)
GRB10 [cytosol] (Homo sapiens)
External Reference Information
External Reference
UniProt:Q13322 GRB10
Gene Names
GRB10, GRBIR, KIAA0207
Chain
chain:1-594
Reference Genes
COSMIC (genes):GRB10 GRB10
dbSNP Gene:2887 GRB10
ENSEMBL:ENSG00000106070 GRB10
Participates
as a component of
active FLT3:GRB10 [plasma membrane] (Homo sapiens)
GRB10:INSR [plasma membrane] (Homo sapiens)
as an input of
Active FLT3 binds to GRB10 (Homo sapiens)
Binding of Grb10 to the insulin receptor (Homo sapiens)
as a member of
GRB7,GRB10 [cytosol] (Homo sapiens)
Adapter proteins [cytosol] (Homo sapiens)
as an output of
Expression of GRB10 (Homo sapiens)
Other forms of this molecule
p-Y GRB10 [cytosol]
Inferred To
grb10a [cytosol]
(Danio rerio)
GRB10 [cytosol]
(Bos taurus)
GRB10 [cytosol]
(Canis familiaris)
GRB10 [cytosol]
(Gallus gallus)
Grb10 [cytosol]
(Mus musculus)
Grb10 [cytosol]
(Rattus norvegicus)
Grb10 [cytosol]
(Sus scrofa)
grb10 [cytosol]
(Xenopus tropicalis)
Interactors (12)
Accession
#Entities
Entities
Confidence Score
Evidence (IntAct)
UniProt:P00533 EGFR
20
p-6Y-EGFR [clathrin-coated endocytic vesicle membrane]
(R-HSA-8869138)
p-5Y-EGFRvIII [plasma membrane]
(R-HSA-1248649)
EGFRvIII [plasma membrane]
(R-HSA-1214162)
p-6Y-EGFR E746_A750del;T790M [plasma membrane]
(R-HSA-1182985)
p-6Y-EGFR L858R;T790M [plasma membrane]
(R-HSA-1182984)
p-6Y-EGFR A767_V769dup [plasma membrane]
(R-HSA-1996343)
p-6Y-EGFR N771_H773dup [plasma membrane]
(R-HSA-1996342)
p-6Y-EGFR K739_I744dup [plasma membrane]
(R-HSA-1996346)
p-6Y-EGFR D770_N771insNPG [plasma membrane]
(R-HSA-1996335)
p-6Y-EGFR E746_A750del [plasma membrane]
(R-HSA-1181214)
p-6Y-EGFR L858R [plasma membrane]
(R-HSA-1173211)
p-6Y-EGFR G719S [plasma membrane]
(R-HSA-1169417)
p-6Y-EGFR L747_P753delinsS [plasma membrane]
(R-HSA-1228038)
p-6Y-EGFR L747_A750delinsP [plasma membrane]
(R-HSA-1228044)
p-6Y-EGFR L747_T751del [plasma membrane]
(R-HSA-1228041)
p-6Y-EGFR L747_S752del [plasma membrane]
(R-HSA-1228040)
p-6Y-EGFR L747_T751delinsP [plasma membrane]
(R-HSA-1228042)
p-6Y-EGFR E746_T751delinsA [plasma membrane]
(R-HSA-1228037)
p-6Y-EGFR E746_S752delinsV [plasma membrane]
(R-HSA-1228039)
p-6Y-EGFR L861Q [plasma membrane]
(R-HSA-1177541)
0.729
4
UniProt:Q04917 YWHAH
1
YWHAH [cytosol]
(R-HSA-1445107)
0.643
4
UniProt:P61981 YWHAG
1
YWHAG [cytosol]
(R-HSA-380312)
0.643
4
UniProt:P36888 FLT3
20
FLT3 F691I [plasma membrane]
(R-HSA-9702900)
FLT3 N676D [plasma membrane]
(R-HSA-9702895)
FLT3 R834Q [plasma membrane]
(R-HSA-9691899)
FLT3 Y572C [plasma membrane]
(R-HSA-9691902)
FLT3 A848P [plasma membrane]
(R-HSA-9702909)
FLT3 A627P [plasma membrane]
(R-HSA-9699448)
FLT3 F621L [plasma membrane]
(R-HSA-9699426)
p-Y768,Y969 FLT3 [plasma membrane]
(R-HSA-9698405)
Ub-pY FLT3 [endosome membrane]
(R-HSA-9706174)
Ub-pY FLT3 [plasma membrane]
(R-HSA-9706171)
FLT3 V592G [plasma membrane]
(R-HSA-9691071)
FLT3 F590_F605dup [plasma membrane]
(R-HSA-9697939)
FLT3 F590G Y591D [plasma membrane]
(R-HSA-9691062)
FLT3 F594L [plasma membrane]
(R-HSA-9691058)
FLT3 E611_F612insGDNEYFYVDFREYEYDLKWEFPRENLE [plasma membrane]
(R-HSA-9699433)
FLT3 V579A [plasma membrane]
(R-HSA-9691051)
FLT3 Y599_D600insGLYVDFREYEY [plasma membrane]
(R-HSA-9696044)
FLT3 Y591_V592insVDFREDREHH [plasma membrane]
(R-HSA-9696043)
FLT3 D600_L601insMGMGGECNPGRQ [plasma membrane]
(R-HSA-9690076)
FLT3 E598_Y599insGLVQVTGSSDNEYFYVDFREYE [plasma membrane]
(R-HSA-9696033)
0.591
6
UniProt:P06213 INSR
6
p-6Y-INSR(763-1382) [endosome membrane]
(R-HSA-141719)
INSR(763-1382) [endosome membrane]
(R-HSA-141722)
INSR(28-758) [endosome membrane]
(R-HSA-141718)
INSR(763-1382) [plasma membrane]
(R-HSA-74669)
p-6Y-INSR(763-1382) [plasma membrane]
(R-HSA-74670)
INSR(28-758) [plasma membrane]
(R-HSA-74668)
0.581
4
UniProt:Q9UKA8 RCAN3
1
RCAN3 [cytosol]
(R-HSA-9728800)
0.57
3
UniProt:P31947 SFN
1
SFN [cytosol]
(R-HSA-1445105)
0.564
2
UniProt:P62258 YWHAE
1
YWHAE [cytosol]
(R-HSA-194368)
0.564
3
UniProt:P08069 IGF1R
3
p-Y1161,Y1165,Y1166-IGF1R(741-1367) [plasma membrane]
(R-HSA-2404172)
IGF1R(31-736) [plasma membrane]
(R-HSA-2404169)
IGF1R(741-1367) [plasma membrane]
(R-HSA-2404180)
0.527
2
UniProt:Q66LE6 PPP2R2D
1
PPP2R2D [nucleoplasm]
(R-HSA-2160962)
0.527
3
UniProt:P54762 EPHB1
6
p-Y594,Y600-EPHB1 [plasma membrane]
(R-HSA-3928347)
EPHB1 [plasma membrane]
(R-HSA-2682340)
EPHB1 (18-?) [extracellular region]
(R-HSA-3928393)
EPHB1 (?-984) [plasma membrane]
(R-HSA-3928402)
EPHB1 (?-984) [cytosol]
(R-HSA-3928438)
EPHB1 (?-?) [plasma membrane]
(R-HSA-3928449)
0.499
2
UniProt:Q9UQB8-6 BAIAP2
0.488
2
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