Reactome | RNF138 [cytosol]

RNF138 [cytosol]

Stable Identifier

R-HSA-976008

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

cytosol

Synonyms

E3 ubiquitin-protein ligase RNF138, RN138_HUMAN

Locations in the PathwayBrowser

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External Reference Information

External Reference

UniProt:Q8WVD3 RNF138

Gene Names

RNF138, NARF, HSD-4, HSD4

Chain

initiator methionine:, chain:2-245

Reference Genes

BioGPS Gene:51444 RNF138

COSMIC (genes):RNF138 RNF138

CTD Gene:51444 RNF138

dbSNP Gene:51444 RNF138

ENSEMBL:ENSG00000134758 RNF138

ENSEMBL_homo_sapiens_GENE:ENSG00000134758.14 RNF138

HGNC:17765 RNF138

KEGG Gene (Homo sapiens):51444 RNF138

Monarch:51444 RNF138

NCBI Gene:51444 RNF138

OMIM:616319 RNF138

UCSC:Q8WVD3 RNF138

Reference Transcript

Other Identifiers

11723230_a_at

11723231_s_at

11723232_x_at

11758333_s_at

16851810

218738_PM_s_at

218738_s_at

239143_3p_x_at

239143_PM_x_at

239143_x_at

2857251

2857252

3783750

3783751

3783752

3783759

3783760

3783761

3783766

3783767

3783768

3783769

3783771

3783772

3783773

3783774

48569_at

48570_at

50567_r_at

51444

8020814

A_23_P89755

A_24_P202512

GE62688

GO:0000724

GO:0003677

GO:0003697

GO:0003824

GO:0005515

GO:0005634

GO:0005694

GO:0006281

GO:0006310

GO:0006974

GO:0010792

GO:0016055

GO:0016567

GO:0016740

GO:0019901

GO:0023052

GO:0035861

GO:0036211

GO:0043226

GO:0046872

GO:0061630

GO:0140096

GO:1990830

HMNXSV003011730

Hs.122139.0.A1_3p_at

Hs.122139.0.A1_3p_s_at

Hs.122139.0.A1_3p_x_at

ILMN_1655165

PH_hs_0029343

TC18000133.hg

g7706722_3p_a_at

Participates

as a candidate of

E3 ligases in proteasomal degradation [cytosol] (Homo sapiens)

Inferred To

RNF138 [cytosol] (Bos taurus)

RNF138 [cytosol] (Canis familiaris)

RNF138 [cytosol] (Gallus gallus)

RNF138 [cytosol] (Mus musculus)

RNF138 [cytosol] (Rattus norvegicus)

RNF138 [cytosol] (Sus scrofa)

Cross References

RefSeq

XP_005258343.1, NP_937761.1, NP_001178253.2, NP_057355.2

OpenTargets

ENSG00000134758

HPA

ENSG00000134758-RNF138

GeneCards

Q8WVD3

Ensembl

ENSP00000257190, ENSG00000134758, ENST00000261593, ENST00000257190, ENSP00000261593

PRO

Q8WVD3

Pharos - Targets

Q8WVD3

HMDB Protein

HMDBP11561

Interactors (6)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P07550 ADRB2	5	pS-ADRB2 [clathrin-coated endocytic vesicle membrane] (R-HSA-8869143) ADRB2 [endosome membrane] (R-HSA-6783036) PolyUb-ADRB2 [endosome membrane] (R-HSA-6783066) pS-ADRB2 [plasma membrane] (R-HSA-8852158) ADRB2 [plasma membrane] (R-HSA-390647)	0.556	3
UniProt:P37840 SNCA	5	SNCA A30P [cytosol] (R-HSA-5658569) SNCA [extracellular region] (R-HSA-976954) Ub-SNCA [cytosol] (R-HSA-5660754) p-S129-SNCA [cytosol] (R-HSA-9836432) SNCA [cytosol] (R-HSA-5658500)	0.556	3
UniProt:P02545 LMNA	3	LMNA(1-646) [nuclear envelope] (R-HSA-535479) LMNA(1-567)-RAF1(279-648) fusion [cytosol] (R-HSA-6802399) LMNA(1-567)-p-RAF1(279-648) fusion [cytosol] (R-HSA-6802537)	0.556	3
UniProt:P06396 GSN	7	GSN(200-270) [extracellular region] (R-HSA-976940) GSN [secretory granule lumen] (R-HSA-6801486) GSN [extracellular region] (R-HSA-6806510) GSN [ficolin-1-rich granule lumen] (R-HSA-6801465) GSN(404-782) [cytosol] (R-HSA-350272) GSN(28-403) [cytosol] (R-HSA-201618) GSN [cytosol] (R-HSA-350275)	0.556	3
UniProt:Q14957 GRIN2C	3	GRIN2C [plasma membrane] (R-HSA-419560) p-Y-GRIN2C [plasma membrane] (R-HSA-9612189) GRIN2C [endoplasmic reticulum membrane] (R-HSA-9609761)	0.556	3
UniProt:Q16595 FXN	6	FXN(1-210) [mitochondrial intermembrane space] (R-HSA-1299451) FXN(1-41) [mitochondrial matrix] (R-HSA-8986117) FXN(81-210) [mitochondrial matrix] (R-HSA-1362390) FXN(42-210) [mitochondrial inner membrane] (R-HSA-1299454) FXN(42-210) [mitochondrial matrix] (R-HSA-1299445) FXN(1-210) [mitochondrial inner membrane] (R-HSA-1299444)	0.556	3

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