Reactome | HTRA2 [mitochondrial intermembrane space]

HTRA2 [mitochondrial intermembrane space]

Stable Identifier

R-HSA-56655

Type

Protein [EntityWithAccessionedSequence]

Species

Homo sapiens

Compartment

mitochondrial intermembrane space

Synonyms

OMI, Serine protease HTRA2, mitochondrial precursor , High temperature requirement protein A2, HtrA2, Omi stress-regulated endoprotease, Serine proteinase OMI

Locations in the PathwayBrowser

Expand all

External Reference Information

External Reference

UniProt:O43464 HTRA2

Gene Names

HTRA2, OMI, PRSS25

Chain

transit peptide:1-31, propeptide:32-133, chain:134-458

Reference Genes

BioGPS Gene:27429 HTRA2

COSMIC (genes):HTRA2 HTRA2

CTD Gene:27429 HTRA2

dbSNP Gene:27429 HTRA2

ENSEMBL:ENSG00000115317 HTRA2

ENSEMBL_homo_sapiens_GENE:ENSG00000115317.13 HTRA2

HGNC:14348 HTRA2

KEGG Gene (Homo sapiens):27429 HTRA2

Monarch:27429 HTRA2

NCBI Gene:27429 HTRA2

OMIM:606441 HTRA2

UCSC:O43464 HTRA2

Reference Transcript

Other Identifiers

11726630_a_at

11742245_a_at

11755452_x_at

11756421_x_at

16881786

203089_PM_s_at

203089_s_at

211152_PM_s_at

211152_s_at

2489412

2489413

2489414

2489415

2489416

2489417

2489418

2489420

2489421

2489424

2489427

2489428

2489430

2489432

2489433

2489434

2489435

2489436

2489437

27429

39845_at

8042905

GE58502

GO:0000785

GO:0003824

GO:0004252

GO:0005515

GO:0005634

GO:0005694

GO:0005739

GO:0005758

GO:0005783

GO:0005789

GO:0005829

GO:0005856

GO:0005886

GO:0006508

GO:0006629

GO:0006672

GO:0006886

GO:0006914

GO:0006915

GO:0007005

GO:0007628

GO:0008233

GO:0008236

GO:0008344

GO:0008630

GO:0009635

GO:0009898

GO:0010822

GO:0012501

GO:0016020

GO:0016540

GO:0016787

GO:0019742

GO:0023052

GO:0030154

GO:0030163

GO:0030900

GO:0031966

GO:0034599

GO:0034605

GO:0035458

GO:0035631

GO:0040014

GO:0042802

GO:0043065

GO:0043226

GO:0043280

GO:0043524

GO:0045786

GO:0048666

GO:0048856

GO:0051082

GO:0051402

GO:0051604

GO:0071300

GO:0071363

GO:0097193

GO:0097194

GO:0140096

GO:1902176

GO:1903146

GO:1903955

GO:1904924

GO:1905370

GO:2001241

GO:2001269

HMNXSV003010008

ILMN_1747204

ILMN_1785574

PH_hs_0006334

TC02000463.hg

g10121319_3p_a_at

Participates

as a component of

HTRA2 trimer [mitochondrial intermembrane space] (Homo sapiens)

as an output of

p-S167-ESR1 activates expression of HTRA2 (OMI) (Homo sapiens)

Inferred To

Htra2 [mitochondrial intermembrane space] (Mus musculus)

Htra2 [mitochondrial intermembrane space] (Rattus norvegicus)

HTRA2 [mitochondrial intermembrane space] (Bos taurus)

HTRA2 [mitochondrial intermembrane space] (Canis familiaris)

HTRA2 [mitochondrial intermembrane space] (Plasmodium falciparum)

HTRA2 [mitochondrial intermembrane space] (Sus scrofa)

HtrA2 [mitochondrial intermembrane space] (Drosophila melanogaster)

Cross References

RefSeq

NP_037379.1, NP_001308656.1, NP_659540.1

OpenTargets

ENSG00000115317

HPA

ENSG00000115317-HTRA2

GeneCards

O43464

Ensembl

ENSP00000258080, ENSP00000312893, ENSG00000115317, ENST00000437202, ENSP00000399166, ENST00000352222, ENST00000258080

PRO

O43464

Pharos - Targets

O43464

Orphanet

16235

PDB

7VGE, 5M3O, 5TNZ, 5TO0, 8AUK, 5FHT, 5WYN, 5M3N, 1LCY, 5TNY, 8E2K, 5TO1, 2PZD

Interactors (82)

Accession	#Entities	Entities	Confidence Score	Evidence (IntAct)
UniProt:P98170 XIAP	3	XIAP [nucleoplasm] (R-HSA-3322366) K48pUb-XIAP [cytosol] (R-HSA-5675477) XIAP [cytosol] (R-HSA-50849)	0.959	23
UniProt:P02666 CASB			0.801	7
UniProt:Q8IUR7 ARMC8	4	ARMC8 [specific granule lumen] (R-HSA-6799508) ARMC8 [extracellular region] (R-HSA-6806294) ARMC8 [tertiary granule lumen] (R-HSA-6800958) ARMC8 [cytosol] (R-HSA-9861612)	0.676	5
UniProt:Q9P0J0 NDUFA13	8	NDUFA13 [mitochondrial inner membrane] (R-HSA-59936) NDUFA13(41-49) [mitochondrial inner membrane] (R-HSA-9839958) NDUFA13(100-108) [mitochondrial inner membrane] (R-HSA-9839959) NDUFA13(109-144) [mitochondrial inner membrane] (R-HSA-9839968) NDUFA13(2-19) [mitochondrial inner membrane] (R-HSA-9839966) NDUFA13(69-99) [mitochondrial inner membrane] (R-HSA-9839964) NDUFA13(20-40) [mitochondrial inner membrane] (R-HSA-9839963) NDUFA13(50-68) [mitochondrial inner membrane] (R-HSA-9839961)	0.674	7
UniProt:Q6DKK2 TTC19	1	TTC19 [mitochondrial inner membrane] (R-HSA-9906047)	0.659	4
UniProt:Q13490 BIRC2	5	K63polyUb-BIRC2 [cytosol] (R-HSA-5668512) BIRC2(1-372) [cytosol] (R-HSA-202913) BIRC2(373-618) [cytosol] (R-HSA-202931) K48pUb-BIRC2 [cytosol] (R-HSA-5675479) BIRC2 [cytosol] (R-HSA-50847)	0.65	4
UniProt:Q96CA5 BIRC7	1	BIRC7 [cytosol] (R-HSA-50855)	0.641	5
UniProt:Q12933 TRAF2	5	TRAF2 [nucleoplasm] (R-HSA-8862199) K63polyUb-TRAF2 [nucleoplasm] (R-HSA-8862194) K63polyUb-TRAF2 [cytosol] (R-HSA-8862193) PolyUb-TRAF2 [cytosol] (R-HSA-6782848) TRAF2 [cytosol] (R-HSA-66370)	0.615	3
UniProt:Q15287 RNPS1	2	RNPS1 [nucleoplasm] (R-HSA-156778) RNPS1 [cytosol] (R-HSA-159256)	0.564	2
IntAct:EBI-25850457 CCSB			0.556	3
UniProt:Q9NR46 SHLB2			0.556	3
UniProt:Q99871 HAUS7	1	HAUS7 [cytosol] (R-HSA-8855200)	0.556	3
UniProt:Q02363 ID2	1	ID2 [nucleoplasm] (R-HSA-452391)	0.556	3
UniProt:Q86V28 Q86V28			0.556	3
UniProt:Q9Y2M5 KLHL20	1	KLHL20 [cytosol] (R-HSA-976032)	0.556	3
UniProt:O15381-5 O153815			0.556	3
UniProt:Q5VWN6 TASO2			0.556	3
UniProt:O14813 PHX2A			0.556	3
UniProt:Q96T49 PP16B			0.556	3
UniProt:O60304 ZNF500	1	ZNF500 [nucleoplasm] (R-HSA-1247856)	0.556	3
UniProt:Q495M9 USH1G	1	USH1G [cytosol] (R-HSA-9658869)	0.556	3
UniProt:Q1L5Z9 LONF2			0.556	3
UniProt:Q96D59 RN183			0.556	3
UniProt:P02489 CRYAA			0.556	3
UniProt:Q96FT7-4 ASIC4			0.556	3
UniProt:Q86TN1 Q86TN1			0.556	3
UniProt:O15535 ZSC9			0.556	3
UniProt:Q9HBE1-4 PATZ1			0.556	3
UniProt:Q16637-3 SMN1			0.556	3
UniProt:Q8N0Y2-2 ZNF444			0.556	3
UniProt:Q9UNY5 ZN232			0.556	3
UniProt:Q8NA82 MARHA			0.556	3
UniProt:P57052 RBM11			0.556	3
UniProt:Q8N5Z5 KCD17			0.556	3
UniProt:Q8N594 MPND			0.556	3
UniProt:Q5TAQ9-2 Q5TAQ92			0.556	3
UniProt:Q9NUU6 OTULL			0.556	3
UniProt:Q8TC29 ENKUR			0.556	3
UniProt:Q8NEZ2 VPS37A	1	VPS37A [endosome membrane] (R-HSA-184333)	0.556	3
IntAct:EBI-25842456 CCSB			0.556	3
UniProt:Q8WWB5 PIHD2			0.556	3
UniProt:Q8WVD3 RNF138	1	RNF138 [cytosol] (R-HSA-976008)	0.556	3
UniProt:Q8WXH5 SOCS4	1	SOCS4 [cytosol] (R-HSA-8936109)	0.556	3
UniProt:Q96FW1 OTUB1	2	OTUB1 [cytosol] (R-HSA-933411) OTUB1 [nucleoplasm] (R-HSA-6783242)	0.556	3
UniProt:Q9Y575-3 ASB3			0.556	3
UniProt:Q6ZTN6-2 ANKRD13D			0.556	3
UniProt:Q6ZMI0-5 PPP1R21			0.556	3
UniProt:Q14525 KRT33B	1	KRT33B [cytosol] (R-HSA-6809594)	0.556	3
UniProt:Q8N6K7-2 SAMD3			0.556	3
IntAct:EBI-25843264 CCSB			0.556	3
UniProt:Q6GQQ9-2 Q6GQQ92			0.556	3
UniProt:Q15007-2 WTAP			0.556	3
UniProt:Q96DX5-3 Q96DX53			0.556	3
UniProt:P57682 KLF3			0.556	3
UniProt:Q8WY64 MYLIP	1	MYLIP [cytosol] (R-HSA-8850908)	0.556	3
UniProt:Q8IY31-2 IFT20			0.556	3
UniProt:Q6P597 KLC3	1	KLC3 [cytosol] (R-HSA-983232)	0.556	3
UniProt:O95150 TNFSF15	1	TNFSF15 [plasma membrane] (R-HSA-5667157)	0.556	3
UniProt:Q96GM5 SMARCD1	1	SMARCD1 [nucleoplasm] (R-HSA-389255)	0.556	3
UniProt:O00303 EIF3F	1	EIF3F [cytosol] (R-HSA-72540)	0.556	3
UniProt:Q9NV79 PCMD2			0.556	3
UniProt:Q96GQ5 RUSF1			0.556	3
UniProt:O00308 WWP2	1	WWP2 [cytosol] (R-HSA-6807279)	0.556	3
UniProt:Q13216-2 ERCC8			0.556	3
UniProt:P24278 ZBT25			0.556	3
UniProt:Q7Z7K6 CENPV			0.556	3
UniProt:O75925 PIAS1	1	PIAS1 [nucleoplasm] (R-HSA-877307)	0.556	3
UniProt:Q86WV5 TEN1	1	TEN1 [nucleoplasm] (R-HSA-9668823)	0.556	3
UniProt:O75604-3 USP2			0.556	3
UniProt:Q8N488 RYBP	1	RYBP [nucleoplasm] (R-HSA-8937975)	0.556	3
IntAct:EBI-25843276 CCSB			0.556	3
UniProt:P08727 KRT19	1	KRT19 [cytosol] (R-HSA-6809617)	0.556	3
UniProt:Q99683 MAP3K5	1	MAP3K5 [cytosol] (R-HSA-167709)	0.556	3
UniProt:Q13562 NEUROD1	1	NEUROD1 [nucleoplasm] (R-HSA-186689)	0.556	3
UniProt:P17980 PSMC3	5	PSMC3 [secretory granule lumen] (R-HSA-6800917) PSMC3 [extracellular region] (R-HSA-6806496) PSMC3 [ficolin-1-rich granule lumen] (R-HSA-6800429) PSMC3 [nucleoplasm] (R-HSA-174313) PSMC3 [cytosol] (R-HSA-68774)	0.556	3
UniProt:P61289 PSME3	1	PSME3 [cytosol] (R-HSA-68816)	0.527	2
UniProt:P31943 HNRNPH1	1	HNRNPH1 [nucleoplasm] (R-HSA-71941)	0.527	2
UniProt:Q7L5Y9 MAEA	1	MAEA [cytosol] (R-HSA-9861711)	0.508	2
UniProt:Q9UL63 MKLN1	1	Muskelin [cytosol] (R-HSA-9861557)	0.508	2
UniProt:Q6VN20 RANBP10	1	RANBP10 [cytosol] (R-HSA-8851865)	0.508	2
UniProt:Q9H7D7 WDR26	1	WDR26 [cytosol] (R-HSA-9861584)	0.508	2
UniProt:Q9NWU2 GID8	1	GID8 [cytosol] (R-HSA-9861665)	0.483	2

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